Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F. J. Ketelhuth; Esther Lutgens; Magnus Back; Christoph J. Binder; Jan Van den Bossche; Carolin Daniel; Ingrid E. Dumitriu; Imo Hoefer; Peter Libby; Luke O'Neill; Christian Weber; Paul C. Evans

doi:10.1093/cvr/cvz166

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Daniel F. J. Ketelhuth, Esther Lutgens, Magnus Back, Christoph J. Binder, Jan Van den Bossche, Carolin Daniel, Ingrid E. Dumitriu, Imo Hoefer, Peter Libby, Luke O'Neill, Christian Weber, Paul C. Evans^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

40 Citations (Web of Science)

Abstract

Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

Original language	English
Pages (from-to)	1385-1392
Number of pages	8
Journal	Cardiovascular Research
Volume	115
Issue number	9
DOIs	https://doi.org/10.1093/cvr/cvz166
Publication status	Published - 15 Jul 2019

Keywords

Atherosclerosis
Vascular
Inflammation
Immune system
Metabolism
REGULATORY T-CELLS
TRIMETHYLAMINE N-OXIDE
MACROPHAGE IMMUNOMETABOLISM
DENDRITIC CELLS
IMAGING ATHEROSCLEROSIS
GLUTAMINE UPTAKE
IMMUNE-RESPONSE
METABOLISM
INFLAMMATION
INDUCTION

Access to Document

10.1093/cvr/cvz166

Cite this

Ketelhuth, D. F. J., Lutgens, E., Back, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C., & Evans, P. C. (2019). Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovascular Research, 115(9), 1385-1392. https://doi.org/10.1093/cvr/cvz166

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title = "Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology",

abstract = "Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.",

keywords = "Atherosclerosis, Vascular, Inflammation, Immune system, Metabolism, REGULATORY T-CELLS, TRIMETHYLAMINE N-OXIDE, MACROPHAGE IMMUNOMETABOLISM, DENDRITIC CELLS, IMAGING ATHEROSCLEROSIS, GLUTAMINE UPTAKE, IMMUNE-RESPONSE, METABOLISM, INFLAMMATION, INDUCTION",

author = "Ketelhuth, {Daniel F. J.} and Esther Lutgens and Magnus Back and Binder, {Christoph J.} and {Van den Bossche}, Jan and Carolin Daniel and Dumitriu, {Ingrid E.} and Imo Hoefer and Peter Libby and Luke O'Neill and Christian Weber and Evans, {Paul C.}",

year = "2019",

month = jul,

day = "15",

doi = "10.1093/cvr/cvz166",

language = "English",

volume = "115",

pages = "1385--1392",

journal = "Cardiovascular Research",

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Ketelhuth, DFJ, Lutgens, E, Back, M, Binder, CJ, Van den Bossche, J, Daniel, C, Dumitriu, IE, Hoefer, I, Libby, P, O'Neill, L, Weber, C & Evans, PC 2019, 'Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology', Cardiovascular Research, vol. 115, no. 9, pp. 1385-1392. https://doi.org/10.1093/cvr/cvz166

Immunometabolism and atherosclerosis : perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. / Ketelhuth, Daniel F. J.; Lutgens, Esther; Back, Magnus et al.

In: Cardiovascular Research, Vol. 115, No. 9, 15.07.2019, p. 1385-1392.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

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AU - Ketelhuth, Daniel F. J.

AU - Lutgens, Esther

AU - Back, Magnus

AU - Binder, Christoph J.

AU - Van den Bossche, Jan

AU - Daniel, Carolin

AU - Dumitriu, Ingrid E.

AU - Hoefer, Imo

AU - Libby, Peter

AU - O'Neill, Luke

AU - Weber, Christian

AU - Evans, Paul C.

PY - 2019/7/15

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N2 - Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

AB - Inflammation is an important driver of atherosclerosis, and the favourable outcomes of the Canakinumab Anti-inflammatory Thrombosis Outcome Study (CANTOS) trial revealed the large potential of anti-inflammatory drugs for the treatment of cardiovascular disease, especially in patients with a pro-inflammatory constitution. However, the complex immune reactions driving inflammation in the vascular wall in response to an atherosclerotic microenvironment are still being unravelled. Novel insights into the cellular processes driving immunity and inflammation revealed that alterations in intracellular metabolic pathways are strong drivers of survival, growth, and function of immune cells. Therefore, this position paper presents a brief overview of the recent developments in the immunometabolism field, focusing on its role in atherosclerosis. We will also highlight the potential impact of immunometabolic markers and targets in clinical cardiovascular medicine.

KW - Atherosclerosis

KW - Vascular

KW - Inflammation

KW - Immune system

KW - Metabolism

KW - REGULATORY T-CELLS

KW - TRIMETHYLAMINE N-OXIDE

KW - MACROPHAGE IMMUNOMETABOLISM

KW - DENDRITIC CELLS

KW - IMAGING ATHEROSCLEROSIS

KW - GLUTAMINE UPTAKE

KW - IMMUNE-RESPONSE

KW - METABOLISM

KW - INFLAMMATION

KW - INDUCTION

U2 - 10.1093/cvr/cvz166

DO - 10.1093/cvr/cvz166

M3 - Review article

VL - 115

SP - 1385

EP - 1392

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 9

ER -