Immune regulation by mimethyl fumarate (DMF) in relapsing-remitting multiple sclerosis patients

Gwendoline Montes Diaz

Research output: ThesisDoctoral ThesisExternal prepared

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Multiple sclerosis (MS) is a disease that is caused when the patient’s own immune cells attack the central nervous system, i.e. an autoimmune disease. The disease has a prevalence of 1-2.5 million people worldwide, but there is no known cure. Dimethyl fumurate (DMF), also known as Tecfidera®, is an oral therapy for the treatment of relapsing-remitting multiple sclerosis (RRMS). However, how DMF works in RRMS patients is not fully understood.

The main goal of this study is to explore the effects of DMF treatment on the immune cells, as well as on their functionality. This study has provided valuable evidence on the effect of DMF on the immune system in MS and may contribute to revealing an underlying mechanism for the beneficial effects of the therapy which have been demonstrated by phase III trials.
Funded by Biogen Nederland
Original languageEnglish
Awarding Institution
  • Maastricht University
  • tUL-Universiteit Hasselt (UHasselt)
  • Somers, Veerle, Supervisor, External person
  • Hupperts, Raymond, Supervisor
  • Fraussen, Judith, Co-Supervisor, External person
Award date15 Oct 2020
Publication statusPublished - 2020


  • multiple sclerosis (MS)
  • dimethyl fumarate
  • autoimmune disease
  • MS therapy

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