Immune modulation by dietary glucans from oat and mushrooms; results from in vitro, animal and human studies

J.J. Volman

    Research output: ThesisDoctoral ThesisInternal

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    There is more and more evidence that the immune reaction, and along with that the risk of certain diseases, is influenced by nutrients. Examples of such a nutrient are glucans that are found in oats and mushrooms. Therefore, in this dissertation we studied the effects of a- and b-glucans on immune reactions in the intestine and to a lesser degree in the entire body (systemic immune reactions). Our studies showed that the consumption of b-glucan from oats advance the immune reaction in the intestine in vitro (“in the test-tube”) in people and in vivo (“in the body”) in mice, while it does not stimulate the systemic immune reaction. Consumption of both a- and b-glucans from mushrooms stimulate the systemic immune cells of mice in vitro but the a-glucans had no clear effect on the systemic immune response in people.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    • Mensink, Ronald, Supervisor
    • Plat, Jogchum, Co-Supervisor
    Award date26 Feb 2010
    Place of PublicationMaastricht
    Print ISBNs9052789118
    Publication statusPublished - 1 Jan 2009


    • Immune system
    • Nutrition
    • glucans

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