There is more and more evidence that the immune reaction, and along with that the risk of certain diseases, is influenced by nutrients. Examples of such a nutrient are glucans that are found in oats and mushrooms. Therefore, in this dissertation we studied the effects of a- and b-glucans on immune reactions in the intestine and to a lesser degree in the entire body (systemic immune reactions). Our studies showed that the consumption of b-glucan from oats advance the immune reaction in the intestine in vitro (“in the test-tube”) in people and in vivo (“in the body”) in mice, while it does not stimulate the systemic immune reaction. Consumption of both a- and b-glucans from mushrooms stimulate the systemic immune cells of mice in vitro but the a-glucans had no clear effect on the systemic immune response in people.
|Qualification||Doctor of Philosophy|
|Award date||26 Feb 2010|
|Place of Publication||Maastricht|
|Publication status||Published - 1 Jan 2009|
- Immune system