Immune Homeostasis in Epithelial Cells: Evidence and Role of Inflammasome Signaling Reviewed

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Abstract

The epithelium regulates the interaction between the noxious xenogenous, as well as the microbial environment and the immune system, not only by providing a barrier but also by expressing a number of immunoregulatory membrane receptors, and intracellular danger sensors and their downstream effectors. Amongst these are a number of inflammasome sensor subtypes, which have been initially characterized in myeloid cells and described to be activated upon assembly into multiprotein complexes by microbial and environmental triggers. This review compiles a vast amount of literature that supports a pivotal role for inflammasomes in the various epithelial barriers of the human body as essential factors maintaining immune signaling and homeostasis.
Original languageEnglish
Article number828264
Number of pages15
JournalJournal of Immunology Research
Volume2015
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • GAMMA-INDUCING FACTOR
  • NLRP3 INFLAMMASOME
  • PULMONARY INFLAMMATION
  • CIGARETTE-SMOKE
  • HMGB1 RELEASE
  • HUMAN KERATINOCYTES
  • NALP3 INFLAMMASOME
  • INDUCED ACTIVATION
  • MESSENGER-RNA
  • IN-VITRO

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