Immune checkpoint inhibitors versus second line chemotherapy for patients with lung cancer refractory to first line chemotherapy

C. Lefebvre; E. Martin; L. E. L. Hendriks; R. Veillon; F. Puisset; L. Mezquita; R. Ferrara; M. Sabatier; T. Filleron; A-M C. Dingemans; B. Besse; C. Raherisson; J. Mazieres

doi:10.1016/j.resmer.2020.100788

Immune checkpoint inhibitors versus second line chemotherapy for patients with lung cancer refractory to first line chemotherapy

C. Lefebvre, E. Martin, L. E. L. Hendriks, R. Veillon, F. Puisset, L. Mezquita, R. Ferrara, M. Sabatier, T. Filleron, A-M C. Dingemans, B. Besse, C. Raherisson, J. Mazieres^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose. - Anti Programmed Death-ligand (PD1/PD-L1) directed immune-checkpoint-inhibitors (ICI) are widely used to treat patients with advanced non-small cell lung cancer (NSCLC) who progress after first line chemotherapy. The best strategy after early progression under first line has not been specifically studied.

Patients and methods. - We conducted a multicenter, retrospective study including all consecutive NSCLC patients progressing within the first 3 months following introduction of first-line chemotherapy and being treated with second line ICI monotherapy or chemotherapy between March 2010 and November 2017. We analysed the clinicopathological data and outcome under second line chemotherapy vs. second line ICI: objective response rate (ORR), progression-free survival (PFS), overall survival (OS.

Results. - We identified 176 patients with refractory disease, 99 who received subsequent immunotherapy and 77 undergoing chemotherapy. The 2 populations were comparable regarding the main prognostic criteria, median age was 60, main histology was adenocarcimoma (68.2%). PFS was not significantly different between both treatments 1.9 [1.8-2.1] versus 1.6 month [1.4-2.0] (P = 0.125). Compared to chemotherapy, ICI treated patients had a superior OS (P= 0.03) (Median [95% CI] OS 4.6 [2.8-6.7] versus 4.2 months [3.4-5.9] and a non-significant improvement in ORR (17.2% versus 7.9%, respectively, P = 0.072). Poor performance status (ECOG PS >= 2) and a higher number of metastatic sites (>= 3) were associated with poorer prognosis. KRAS-mutated patients did not seem to benefit more from ICI than chemotherapy.

Conclusions. - ICI appears to be the preferred second-line treatment for patients who are refractory to first line chemotherapy.

Original language	English
Article number	100788
Number of pages	7
Journal	Respiratory medicine and research
Volume	78
DOIs	https://doi.org/10.1016/j.resmer.2020.100788
Publication status	Published - Nov 2020

Keywords

DOCETAXEL
NIVOLUMAB
PHASE-3

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10.1016/j.resmer.2020.100788

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Lefebvre, C., Martin, E., Hendriks, L. E. L., Veillon, R., Puisset, F., Mezquita, L., Ferrara, R., Sabatier, M., Filleron, T., Dingemans, A.-M. C., Besse, B., Raherisson, C., & Mazieres, J. (2020). Immune checkpoint inhibitors versus second line chemotherapy for patients with lung cancer refractory to first line chemotherapy. Respiratory medicine and research, 78, Article 100788. https://doi.org/10.1016/j.resmer.2020.100788

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title = "Immune checkpoint inhibitors versus second line chemotherapy for patients with lung cancer refractory to first line chemotherapy",

abstract = "Purpose. - Anti Programmed Death-ligand (PD1/PD-L1) directed immune-checkpoint-inhibitors (ICI) are widely used to treat patients with advanced non-small cell lung cancer (NSCLC) who progress after first line chemotherapy. The best strategy after early progression under first line has not been specifically studied.Patients and methods. - We conducted a multicenter, retrospective study including all consecutive NSCLC patients progressing within the first 3 months following introduction of first-line chemotherapy and being treated with second line ICI monotherapy or chemotherapy between March 2010 and November 2017. We analysed the clinicopathological data and outcome under second line chemotherapy vs. second line ICI: objective response rate (ORR), progression-free survival (PFS), overall survival (OS.Results. - We identified 176 patients with refractory disease, 99 who received subsequent immunotherapy and 77 undergoing chemotherapy. The 2 populations were comparable regarding the main prognostic criteria, median age was 60, main histology was adenocarcimoma (68.2%). PFS was not significantly different between both treatments 1.9 [1.8-2.1] versus 1.6 month [1.4-2.0] (P = 0.125). Compared to chemotherapy, ICI treated patients had a superior OS (P= 0.03) (Median [95% CI] OS 4.6 [2.8-6.7] versus 4.2 months [3.4-5.9] and a non-significant improvement in ORR (17.2% versus 7.9%, respectively, P = 0.072). Poor performance status (ECOG PS >= 2) and a higher number of metastatic sites (>= 3) were associated with poorer prognosis. KRAS-mutated patients did not seem to benefit more from ICI than chemotherapy.Conclusions. - ICI appears to be the preferred second-line treatment for patients who are refractory to first line chemotherapy.",

keywords = "DOCETAXEL, NIVOLUMAB, PHASE-3",

author = "C. Lefebvre and E. Martin and Hendriks, {L. E. L.} and R. Veillon and F. Puisset and L. Mezquita and R. Ferrara and M. Sabatier and T. Filleron and Dingemans, {A-M C.} and B. Besse and C. Raherisson and J. Mazieres",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

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language = "English",

volume = "78",

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Lefebvre, C, Martin, E, Hendriks, LEL, Veillon, R, Puisset, F, Mezquita, L, Ferrara, R, Sabatier, M, Filleron, T, Dingemans, A-MC, Besse, B, Raherisson, C & Mazieres, J 2020, 'Immune checkpoint inhibitors versus second line chemotherapy for patients with lung cancer refractory to first line chemotherapy', Respiratory medicine and research, vol. 78, 100788. https://doi.org/10.1016/j.resmer.2020.100788

TY - JOUR

T1 - Immune checkpoint inhibitors versus second line chemotherapy for patients with lung cancer refractory to first line chemotherapy

AU - Lefebvre, C.

AU - Martin, E.

AU - Hendriks, L. E. L.

AU - Veillon, R.

AU - Puisset, F.

AU - Mezquita, L.

AU - Ferrara, R.

AU - Sabatier, M.

AU - Filleron, T.

AU - Dingemans, A-M C.

AU - Besse, B.

AU - Raherisson, C.

AU - Mazieres, J.

PY - 2020/11

Y1 - 2020/11

N2 - Purpose. - Anti Programmed Death-ligand (PD1/PD-L1) directed immune-checkpoint-inhibitors (ICI) are widely used to treat patients with advanced non-small cell lung cancer (NSCLC) who progress after first line chemotherapy. The best strategy after early progression under first line has not been specifically studied.Patients and methods. - We conducted a multicenter, retrospective study including all consecutive NSCLC patients progressing within the first 3 months following introduction of first-line chemotherapy and being treated with second line ICI monotherapy or chemotherapy between March 2010 and November 2017. We analysed the clinicopathological data and outcome under second line chemotherapy vs. second line ICI: objective response rate (ORR), progression-free survival (PFS), overall survival (OS.Results. - We identified 176 patients with refractory disease, 99 who received subsequent immunotherapy and 77 undergoing chemotherapy. The 2 populations were comparable regarding the main prognostic criteria, median age was 60, main histology was adenocarcimoma (68.2%). PFS was not significantly different between both treatments 1.9 [1.8-2.1] versus 1.6 month [1.4-2.0] (P = 0.125). Compared to chemotherapy, ICI treated patients had a superior OS (P= 0.03) (Median [95% CI] OS 4.6 [2.8-6.7] versus 4.2 months [3.4-5.9] and a non-significant improvement in ORR (17.2% versus 7.9%, respectively, P = 0.072). Poor performance status (ECOG PS >= 2) and a higher number of metastatic sites (>= 3) were associated with poorer prognosis. KRAS-mutated patients did not seem to benefit more from ICI than chemotherapy.Conclusions. - ICI appears to be the preferred second-line treatment for patients who are refractory to first line chemotherapy.

AB - Purpose. - Anti Programmed Death-ligand (PD1/PD-L1) directed immune-checkpoint-inhibitors (ICI) are widely used to treat patients with advanced non-small cell lung cancer (NSCLC) who progress after first line chemotherapy. The best strategy after early progression under first line has not been specifically studied.Patients and methods. - We conducted a multicenter, retrospective study including all consecutive NSCLC patients progressing within the first 3 months following introduction of first-line chemotherapy and being treated with second line ICI monotherapy or chemotherapy between March 2010 and November 2017. We analysed the clinicopathological data and outcome under second line chemotherapy vs. second line ICI: objective response rate (ORR), progression-free survival (PFS), overall survival (OS.Results. - We identified 176 patients with refractory disease, 99 who received subsequent immunotherapy and 77 undergoing chemotherapy. The 2 populations were comparable regarding the main prognostic criteria, median age was 60, main histology was adenocarcimoma (68.2%). PFS was not significantly different between both treatments 1.9 [1.8-2.1] versus 1.6 month [1.4-2.0] (P = 0.125). Compared to chemotherapy, ICI treated patients had a superior OS (P= 0.03) (Median [95% CI] OS 4.6 [2.8-6.7] versus 4.2 months [3.4-5.9] and a non-significant improvement in ORR (17.2% versus 7.9%, respectively, P = 0.072). Poor performance status (ECOG PS >= 2) and a higher number of metastatic sites (>= 3) were associated with poorer prognosis. KRAS-mutated patients did not seem to benefit more from ICI than chemotherapy.Conclusions. - ICI appears to be the preferred second-line treatment for patients who are refractory to first line chemotherapy.

KW - DOCETAXEL

KW - NIVOLUMAB

KW - PHASE-3

U2 - 10.1016/j.resmer.2020.100788

DO - 10.1016/j.resmer.2020.100788

M3 - Article

C2 - 32980653

VL - 78

JO - Respiratory medicine and research

JF - Respiratory medicine and research

M1 - 100788

ER -