Imaging haemodynamic changes related to seizures: comparison of EEG-based general linear model, independent component analysis of fMRI and intracranial EEG.

R.C. Thornton, R. Rodionov, H. Laufs, S. Vulliemoz, A. Vaudano, D. Carmichael, S. Cannadathu, M. Guye, A. McEvoy, S. Lhatoo, F. Bartolomei, P. Chauvel, B. Diehl, F. de Martino, R.D. Elwes, M.C. Walker, J.S. Duncan, L. Lemieux

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Simultaneous EEC-fMRI can reveal haemodynamic changes associated with epileptic activity which may contribute to understanding seizure onset and propagation.

Methods: Nine of 83 patients with focal epilepsy undergoing pre-surgical evaluation had seizures during EEG-fMRI and analysed using three approaches, two based on the general linear model (GLM) and one using independent component analysis (ICA):

1. EEGs were divided into up to three phases: early ictal EEG change, clinical seizure onset and late ictal EEG change and convolved with a canonical haemodynamic response function (HRF) (canonical GLM analysis).

2. Seizures lasting three scans or longer were additionally modelled using a Fourier basis set across the entire event (Fourier GLM analysis).

3. Independent component analysis (ICA) was applied to the fMRI data to identify ictal BOLD patterns without EEG. The results were compared with intracranial EEG.

Results: The canonical GLM analysis revealed significant BOLD signal changes associated with seizures on EEG in 7/9 patients, concordant with the seizure onset zone in 4/7. The Fourier GLM analysis revealed changes in BOLD signal corresponding with the results of the canonical analysis in two patients. ICA revealed components spatially concordant with the seizure onset zone in all patients (8/9 confirmed by intracranial EEG).

Conclusion: Ictal EEG-fMRI visualises plausible seizure related haemodynamic changes. The GLM approach to analysing EEG-fMRI data reveals localised BOLD changes concordant with the ictal onset zone when scalp EEG reflects seizure onset. ICA provides additional information when scalp EEG does not accurately reflect seizures and may give insight into ictal haemodynamics. 

Original languageEnglish
Pages (from-to)196-205
Number of pages10
JournalNeuroimage
Volume53
Issue number1
DOIs
Publication statusPublished - 15 Oct 2010

Keywords

  • BRAIN
  • FOCAL EPILEPSY
  • ICTAL EEG
  • LOCALIZATION
  • NETWORK
  • SIGNATURES
  • SPIKE
  • TIME-SERIES
  • TRIGGERED FUNCTIONAL MRI
  • WAVE DISCHARGES

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