Imaging Cold-Activated Brown Adipose Tissue Using Dynamic T2*-Weighted Magnetic Resonance Imaging and 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography

B.D. van Rooijen; A.A. van der Lans; B. Brans; J.E. Wildberger; F.M. Mottaghy; P. Schrauwen; W.H. Backes; W.D. van Marken Lichtenbelt

doi:10.1097/RLI.0b013e31829363b8

Imaging Cold-Activated Brown Adipose Tissue Using Dynamic T2*-Weighted Magnetic Resonance Imaging and 2-Deoxy-2-[¹⁸F]fluoro-D-glucose Positron Emission Tomography

B.D. van Rooijen, A.A. van der Lans, B. Brans, J.E. Wildberger, F.M. Mottaghy, P. Schrauwen, W.H. Backes^*, W.D. van Marken Lichtenbelt

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Objectives: The objective of this study was to explore the use of magnetic resonance imaging (Mm) to identify and quantify active brown adipose tissue (BAT) in adult humans. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) combined with computed tomography was used as a reference method to identify active BAT depots and to guide the MRI data analysis.

Materials and Methods: The ethics committee of the institute approved the protocol, and all participants provided written informed consent before participation. Both PET combined with computed tomography and MRI of BAT were performed in 11 healthy volunteers. Brown adipose tissue was activated by cooling the participants using a dedicated water-perfused suit. For the MRI examination of BAT, water-fat imaging and dynamic T2* imaging were performed at an effective temporal resolution of 2 minutes per volume. Water-fat images were derived from a multiecho MRI sequence using the Dixon technique.

Results: 2-Deoxy-2-[F-18]fluoro-D-glucose PET identified active BAT in 8 of the 11 participants. Water-fat MRI showed that BAT depots had a fat fraction of 65.2% (7.0%) compared with 81.5% (5.4%) for the subcutaneous white adipose tissue (paired difference of 16.3% [4.9%]; P <0.05). Dynamic T2* imaging during cold stimulation revealed signal fluctuations that were sensitive to BAT activation. The presence of these components correlated with BAT activation quantified from FDG-PET (r = 0.63; P <0.05).

Conclusions: Although FDG-PET has superior contrast for identifying active BAT, the MRI temporal resolution provides insight in activation dynamics In addition, the flexibility of MRI allows for simultaneous mapping of tissue fat content and functional responses. The results indicate that MRI is a promising addition to PET for the identification of BAT and its activity responses to stimulation. An MRI-based methodology to quantify BAT activity is a highly desirable step in addressing the role of BAT in obesity disorders.

Original language	English
Pages (from-to)	708-714
Number of pages	7
Journal	Investigative Radiology
Volume	48
Issue number	10
DOIs	https://doi.org/10.1097/RLI.0b013e31829363b8
Publication status	Published - Oct 2013

Keywords

brown adipose tissue
magnetic resonance imaging
positron emission tomography
thermogenesis
SPINAL-CORD
HEALTHY
QUANTIFICATION
THERMOGENESIS
STIMULATION
DISEASE
MRI

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van Rooijen, B. D., van der Lans, A. A., Brans, B., Wildberger, J. E., Mottaghy, F. M., Schrauwen, P., Backes, W. H., & van Marken Lichtenbelt, W. D. (2013). Imaging Cold-Activated Brown Adipose Tissue Using Dynamic T2*-Weighted Magnetic Resonance Imaging and 2-Deoxy-2-[¹⁸F]fluoro-D-glucose Positron Emission Tomography. Investigative Radiology, 48(10), 708-714. https://doi.org/10.1097/RLI.0b013e31829363b8

@article{06a23781f639477a8ade42b214597038,

title = "Imaging Cold-Activated Brown Adipose Tissue Using Dynamic T2*-Weighted Magnetic Resonance Imaging and 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography",

abstract = "Objectives: The objective of this study was to explore the use of magnetic resonance imaging (Mm) to identify and quantify active brown adipose tissue (BAT) in adult humans. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) combined with computed tomography was used as a reference method to identify active BAT depots and to guide the MRI data analysis.Materials and Methods: The ethics committee of the institute approved the protocol, and all participants provided written informed consent before participation. Both PET combined with computed tomography and MRI of BAT were performed in 11 healthy volunteers. Brown adipose tissue was activated by cooling the participants using a dedicated water-perfused suit. For the MRI examination of BAT, water-fat imaging and dynamic T2* imaging were performed at an effective temporal resolution of 2 minutes per volume. Water-fat images were derived from a multiecho MRI sequence using the Dixon technique.Results: 2-Deoxy-2-[F-18]fluoro-D-glucose PET identified active BAT in 8 of the 11 participants. Water-fat MRI showed that BAT depots had a fat fraction of 65.2% (7.0%) compared with 81.5% (5.4%) for the subcutaneous white adipose tissue (paired difference of 16.3% [4.9%]; P <0.05). Dynamic T2* imaging during cold stimulation revealed signal fluctuations that were sensitive to BAT activation. The presence of these components correlated with BAT activation quantified from FDG-PET (r = 0.63; P <0.05).Conclusions: Although FDG-PET has superior contrast for identifying active BAT, the MRI temporal resolution provides insight in activation dynamics In addition, the flexibility of MRI allows for simultaneous mapping of tissue fat content and functional responses. The results indicate that MRI is a promising addition to PET for the identification of BAT and its activity responses to stimulation. An MRI-based methodology to quantify BAT activity is a highly desirable step in addressing the role of BAT in obesity disorders.",

keywords = "brown adipose tissue, magnetic resonance imaging, positron emission tomography, thermogenesis, SPINAL-CORD, HEALTHY, QUANTIFICATION, THERMOGENESIS, STIMULATION, DISEASE, MRI",

author = "{van Rooijen}, B.D. and {van der Lans}, A.A. and B. Brans and J.E. Wildberger and F.M. Mottaghy and P. Schrauwen and W.H. Backes and {van Marken Lichtenbelt}, W.D.",

year = "2013",

month = oct,

doi = "10.1097/RLI.0b013e31829363b8",

language = "English",

volume = "48",

pages = "708--714",

journal = "Investigative Radiology",

issn = "0020-9996",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "10",

}

van Rooijen, BD, van der Lans, AA, Brans, B, Wildberger, JE , Mottaghy, FM , Schrauwen, P, Backes, WH & van Marken Lichtenbelt, WD 2013, 'Imaging Cold-Activated Brown Adipose Tissue Using Dynamic T2*-Weighted Magnetic Resonance Imaging and 2-Deoxy-2-[¹⁸F]fluoro-D-glucose Positron Emission Tomography', Investigative Radiology, vol. 48, no. 10, pp. 708-714. https://doi.org/10.1097/RLI.0b013e31829363b8

TY - JOUR

T1 - Imaging Cold-Activated Brown Adipose Tissue Using Dynamic T2*-Weighted Magnetic Resonance Imaging and 2-Deoxy-2-[18F]fluoro-D-glucose Positron Emission Tomography

AU - van Rooijen, B.D.

AU - van der Lans, A.A.

AU - Brans, B.

AU - Wildberger, J.E.

AU - Mottaghy, F.M.

AU - Schrauwen, P.

AU - Backes, W.H.

AU - van Marken Lichtenbelt, W.D.

PY - 2013/10

Y1 - 2013/10

N2 - Objectives: The objective of this study was to explore the use of magnetic resonance imaging (Mm) to identify and quantify active brown adipose tissue (BAT) in adult humans. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) combined with computed tomography was used as a reference method to identify active BAT depots and to guide the MRI data analysis.Materials and Methods: The ethics committee of the institute approved the protocol, and all participants provided written informed consent before participation. Both PET combined with computed tomography and MRI of BAT were performed in 11 healthy volunteers. Brown adipose tissue was activated by cooling the participants using a dedicated water-perfused suit. For the MRI examination of BAT, water-fat imaging and dynamic T2* imaging were performed at an effective temporal resolution of 2 minutes per volume. Water-fat images were derived from a multiecho MRI sequence using the Dixon technique.Results: 2-Deoxy-2-[F-18]fluoro-D-glucose PET identified active BAT in 8 of the 11 participants. Water-fat MRI showed that BAT depots had a fat fraction of 65.2% (7.0%) compared with 81.5% (5.4%) for the subcutaneous white adipose tissue (paired difference of 16.3% [4.9%]; P <0.05). Dynamic T2* imaging during cold stimulation revealed signal fluctuations that were sensitive to BAT activation. The presence of these components correlated with BAT activation quantified from FDG-PET (r = 0.63; P <0.05).Conclusions: Although FDG-PET has superior contrast for identifying active BAT, the MRI temporal resolution provides insight in activation dynamics In addition, the flexibility of MRI allows for simultaneous mapping of tissue fat content and functional responses. The results indicate that MRI is a promising addition to PET for the identification of BAT and its activity responses to stimulation. An MRI-based methodology to quantify BAT activity is a highly desirable step in addressing the role of BAT in obesity disorders.

AB - Objectives: The objective of this study was to explore the use of magnetic resonance imaging (Mm) to identify and quantify active brown adipose tissue (BAT) in adult humans. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) combined with computed tomography was used as a reference method to identify active BAT depots and to guide the MRI data analysis.Materials and Methods: The ethics committee of the institute approved the protocol, and all participants provided written informed consent before participation. Both PET combined with computed tomography and MRI of BAT were performed in 11 healthy volunteers. Brown adipose tissue was activated by cooling the participants using a dedicated water-perfused suit. For the MRI examination of BAT, water-fat imaging and dynamic T2* imaging were performed at an effective temporal resolution of 2 minutes per volume. Water-fat images were derived from a multiecho MRI sequence using the Dixon technique.Results: 2-Deoxy-2-[F-18]fluoro-D-glucose PET identified active BAT in 8 of the 11 participants. Water-fat MRI showed that BAT depots had a fat fraction of 65.2% (7.0%) compared with 81.5% (5.4%) for the subcutaneous white adipose tissue (paired difference of 16.3% [4.9%]; P <0.05). Dynamic T2* imaging during cold stimulation revealed signal fluctuations that were sensitive to BAT activation. The presence of these components correlated with BAT activation quantified from FDG-PET (r = 0.63; P <0.05).Conclusions: Although FDG-PET has superior contrast for identifying active BAT, the MRI temporal resolution provides insight in activation dynamics In addition, the flexibility of MRI allows for simultaneous mapping of tissue fat content and functional responses. The results indicate that MRI is a promising addition to PET for the identification of BAT and its activity responses to stimulation. An MRI-based methodology to quantify BAT activity is a highly desirable step in addressing the role of BAT in obesity disorders.

KW - brown adipose tissue

KW - magnetic resonance imaging

KW - positron emission tomography

KW - thermogenesis

KW - SPINAL-CORD

KW - HEALTHY

KW - QUANTIFICATION

KW - THERMOGENESIS

KW - STIMULATION

KW - DISEASE

KW - MRI

U2 - 10.1097/RLI.0b013e31829363b8

DO - 10.1097/RLI.0b013e31829363b8

M3 - Article

SN - 0020-9996

VL - 48

SP - 708

EP - 714

JO - Investigative Radiology

JF - Investigative Radiology

IS - 10

ER -