Imaging approaches to understand disease complexity: chronic obstructive pulmonary disease as a clinical model

Karin J. C. Sanders, Samuel Y. Ash, George R. Washko, Felix M. Mottaghy, Annemie M. W. J. Schols*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

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Abstract

The clinical manifestations of chronic obstructive pulmonary disease (COPD) reflect an aggregate of multiple pulmonary and extrapulmonary processes. It is increasingly clear that full assessment of these processes is essential to characterize disease burden and to tailor therapy. Medical imaging has advanced such that it is now possible to obtain in vivo insight in the presence and severity of lung disease-associated features. In this review, we have assembled data from multiple disciplines of medical imaging research to review the role of imaging in characterization of COPD. Topics include imaging of the lungs, body composition, and extrapulmonary tissue metabolism. The primary focus is on imaging modalities that are widely available in clinical care settings and that potentially contribute to describing COPD heterogeneity and enhance our insight in underlying pathophysiological processes and their structural and functional effects.

Original languageEnglish
Pages (from-to)512-520
Number of pages9
JournalJournal of Applied Physiology
Volume124
Issue number2
DOIs
Publication statusPublished - Feb 2018

Keywords

  • body composition
  • chronic obstructive pulmonary disease
  • imaging
  • lung
  • INTERSTITIAL LUNG ABNORMALITIES
  • X-RAY ABSORPTIOMETRY
  • MUC5B PROMOTER POLYMORPHISM
  • ADIPOSE-TISSUE VOLUMES
  • AIR-FLOW OBSTRUCTION
  • BODY SKELETAL-MUSCLE
  • COMPUTED-TOMOGRAPHY
  • VISCERAL FAT
  • EMPHYSEMA PATTERNS
  • CHRONIC-BRONCHITIS

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