IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

Zhengxuan Jiang; Peizeng Yang; Shengping Hou; Liping Du; Lin Xie; Hongyan Zhou; Aize Kijlstra

doi:10.1136/ard.2009.119420

IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

Zhengxuan Jiang, Peizeng Yang^*, Shengping Hou, Liping Du, Lin Xie, Hongyan Zhou, Aize Kijlstra

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. Methods Four single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 were genotyped in 338 BD patients and 407 age, sex and ethnically matched healthy controls using a PCR restriction fragment length polymorphism assay. Results A significantly increased prevalence of the homozygous rs17375018 GG genotype and G allele was found in BD patients compared with controls (corrected p (p(c))

Original language	English
Pages (from-to)	1325-1328
Journal	Annals of the Rheumatic Diseases
Volume	69
Issue number	7
DOIs	https://doi.org/10.1136/ard.2009.119420
Publication status	Published - Jul 2010

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title = "IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population",

abstract = "Purpose IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. Methods Four single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 were genotyped in 338 BD patients and 407 age, sex and ethnically matched healthy controls using a PCR restriction fragment length polymorphism assay. Results A significantly increased prevalence of the homozygous rs17375018 GG genotype and G allele was found in BD patients compared with controls (corrected p (p(c)) ",

author = "Zhengxuan Jiang and Peizeng Yang and Shengping Hou and Liping Du and Lin Xie and Hongyan Zhou and Aize Kijlstra",

year = "2010",

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doi = "10.1136/ard.2009.119420",

language = "English",

volume = "69",

pages = "1325--1328",

journal = "Annals of the Rheumatic Diseases",

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T1 - IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

AU - Jiang, Zhengxuan

AU - Yang, Peizeng

AU - Hou, Shengping

AU - Du, Liping

AU - Xie, Lin

AU - Zhou, Hongyan

AU - Kijlstra, Aize

PY - 2010/7

Y1 - 2010/7

N2 - Purpose IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. Methods Four single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 were genotyped in 338 BD patients and 407 age, sex and ethnically matched healthy controls using a PCR restriction fragment length polymorphism assay. Results A significantly increased prevalence of the homozygous rs17375018 GG genotype and G allele was found in BD patients compared with controls (corrected p (p(c))

AB - Purpose IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. Methods Four single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 were genotyped in 338 BD patients and 407 age, sex and ethnically matched healthy controls using a PCR restriction fragment length polymorphism assay. Results A significantly increased prevalence of the homozygous rs17375018 GG genotype and G allele was found in BD patients compared with controls (corrected p (p(c))

U2 - 10.1136/ard.2009.119420

DO - 10.1136/ard.2009.119420

M3 - Article

C2 - 20375120

SN - 0003-4967

VL - 69

SP - 1325

EP - 1328

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 7

ER -

IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

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