IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

Zhengxuan Jiang, Peizeng Yang*, Shengping Hou, Liping Du, Lin Xie, Hongyan Zhou, Aize Kijlstra

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

72 Citations (Web of Science)


Purpose IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. Methods Four single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 were genotyped in 338 BD patients and 407 age, sex and ethnically matched healthy controls using a PCR restriction fragment length polymorphism assay. Results A significantly increased prevalence of the homozygous rs17375018 GG genotype and G allele was found in BD patients compared with controls (corrected p (p(c))
Original languageEnglish
Pages (from-to)1325-1328
JournalAnnals of the Rheumatic Diseases
Issue number7
Publication statusPublished - Jul 2010

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