IL-1/inhibitory kappa B kinase epsilon-induced glycolysis augment epithelial effector function and promote allergic airways disease

Xi Qian, Reem Aboushousha, Cheryl van de Wetering, Shi B. Chia, Eyal Amiel, Robert W. Schneider, Jos L. J. van der Velden, Karolyn G. Lahue, Daisy A. Hoagland, Dylan T. Casey, Nirav Daphtary, Jennifer L. Ather, Matthew J. Randall, Minara Aliyeva, Kendall E. Black, David G. Chapman, Lennart K. A. Lundblad, David H. McMillan, Anne E. Dixon, Vikas AnathyCharles G. Irvin, Matthew E. Poynter, Emiel F. M. Wouters, Pamela M. Vacek, Monique Henket, Florence Schleich, Renaud Louis, Albert van der Vliet, Yvonne M. W. Janssen-Heininger

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)435-450.e10
Number of pages26
JournalJournal of Allergy and Clinical Immunology
Volume142
Issue number2
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • Asthma
  • house dust mite
  • glycolysis
  • IL-1
  • inhibitor of kappa B kinase epsilon
  • lactate
  • lactate dehydrogenase A
  • DENDRITIC CELL ACTIVATION
  • HOUSE-DUST MITE
  • NLRP3 INFLAMMASOME
  • SEVERE ASTHMA
  • MURINE MODEL
  • LUNG-CANCER
  • INTERLEUKIN-1
  • HYPERRESPONSIVENESS
  • LACTATE
  • MICE
  • RESPONSES
  • METABOLISM
  • CELL ACTIVATION
  • INFLAMMATION
  • ASTHMA
  • ACTIVATION PROMOTES

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