In vitro human cell-based models: What can they do and what are their limitations?

Matthias P. Lutolf; Milica Radisic; Jeffrey Beekman; Dan Dongeun Huh; Meritxell Huch; Margherita Yayoi Turco; Zeinab Niloofar Tahmasebi Birgani; Dong Gao; Rui Yao; Hang Lin; Takanori Takebe

doi:10.1016/j.cell.2024.07.042

In vitro human cell-based models: What can they do and what are their limitations?

Matthias P. Lutolf^*, Milica Radisic, Jeffrey Beekman, Dan Dongeun Huh, Meritxell Huch, Margherita Yayoi Turco, Zeinab Niloofar Tahmasebi Birgani, Dong Gao, Rui Yao, Hang Lin, Takanori Takebe

^*Corresponding author for this work

Research output: Contribution to journal › Editorial › Academic › peer-review

Abstract

applied for precision medicine of cystic fibrosis, a rare and progressive multi-organ disease caused by pathological variants of the CFTR gene. We study how novel drugs called their tissue used to create personalized intestinal organoids, despite some variation in growth rates among samples. Cells can be biobanked and propagated in culture in rectal tissue epithelium, whether a model exactly recapitulates the in vivo tissue comes from directly showing that organoid phenotypes in vitro associate with and preI am very grateful that our studies with intestinal organoids could help to get CFTR ensure that these living technologies can eventually be implemented as certified diag

Original language	English
Pages (from-to)	4439-4443
Number of pages	5
Journal	Cell
Volume	187
Issue number	17
DOIs	https://doi.org/10.1016/j.cell.2024.07.042
Publication status	Published - 22 Aug 2024

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title = "In vitro human cell-based models: What can they do and what are their limitations?",

abstract = "applied for precision medicine of cystic fibrosis, a rare and progressive multi-organ disease caused by pathological variants of the CFTR gene. We study how novel drugs called their tissue used to create personalized intestinal organoids, despite some variation in growth rates among samples. Cells can be biobanked and propagated in culture in rectal tissue epithelium, whether a model exactly recapitulates the in vivo tissue comes from directly showing that organoid phenotypes in vitro associate with and preI am very grateful that our studies with intestinal organoids could help to get CFTR ensure that these living technologies can eventually be implemented as certified diag",

author = "Lutolf, {Matthias P.} and Milica Radisic and Jeffrey Beekman and Huh, {Dan Dongeun} and Meritxell Huch and Turco, {Margherita Yayoi} and Birgani, {Zeinab Niloofar Tahmasebi} and Dong Gao and Rui Yao and Hang Lin and Takanori Takebe",

year = "2024",

month = aug,

day = "22",

doi = "10.1016/j.cell.2024.07.042",

language = "English",

volume = "187",

pages = "4439--4443",

journal = "Cell",

issn = "0092-8674",

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TY - JOUR

T1 - In vitro human cell-based models

T2 - What can they do and what are their limitations?

AU - Lutolf, Matthias P.

AU - Radisic, Milica

AU - Beekman, Jeffrey

AU - Huh, Dan Dongeun

AU - Huch, Meritxell

AU - Turco, Margherita Yayoi

AU - Birgani, Zeinab Niloofar Tahmasebi

AU - Gao, Dong

AU - Yao, Rui

AU - Lin, Hang

AU - Takebe, Takanori

PY - 2024/8/22

Y1 - 2024/8/22

N2 - applied for precision medicine of cystic fibrosis, a rare and progressive multi-organ disease caused by pathological variants of the CFTR gene. We study how novel drugs called their tissue used to create personalized intestinal organoids, despite some variation in growth rates among samples. Cells can be biobanked and propagated in culture in rectal tissue epithelium, whether a model exactly recapitulates the in vivo tissue comes from directly showing that organoid phenotypes in vitro associate with and preI am very grateful that our studies with intestinal organoids could help to get CFTR ensure that these living technologies can eventually be implemented as certified diag

AB - applied for precision medicine of cystic fibrosis, a rare and progressive multi-organ disease caused by pathological variants of the CFTR gene. We study how novel drugs called their tissue used to create personalized intestinal organoids, despite some variation in growth rates among samples. Cells can be biobanked and propagated in culture in rectal tissue epithelium, whether a model exactly recapitulates the in vivo tissue comes from directly showing that organoid phenotypes in vitro associate with and preI am very grateful that our studies with intestinal organoids could help to get CFTR ensure that these living technologies can eventually be implemented as certified diag

U2 - 10.1016/j.cell.2024.07.042

DO - 10.1016/j.cell.2024.07.042

M3 - Editorial

SN - 0092-8674

VL - 187

SP - 4439

EP - 4443

JO - Cell

JF - Cell

IS - 17

ER -

In vitro human cell-based models: What can they do and what are their limitations?

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