FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression

Shannon L. Klingel, Armand Valsesia, Arne Astrup, Marie Kunesova, Wim H. M. Saris, Dominique Langin, Nathalie Viguerie, David M. Mutch*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background Single nucleotide polymorphisms (SNPs) in FADS1/FADS2 genes are associated with changes in serum and tissue polyunsaturated fatty acid (PUFA) content. PUFA regulate inflammatory signaling pathways in adipose tissue; however, the effect of SNPs in FADS1/FADS2 on adipose tissue inflammation is equivocal. The present study examined if SNPs in FADS1/FADS2 modify human subcutaneous adipose tissue (SAT) fatty acid profiles and the expression of genes associated with inflammation/immune function, lipid metabolism, and cellular differentiation.

Methods SAT fatty acids and the expression of 117 genes were measured in 174 men and women from the DiOGenes Study using gas chromatography and qRT-PCR, respectively. Associations between fatty acids, gene expression, and SNPs in FADS1/FADS2 were investigated by linear regression and multivariate analysis.

Results Four SNPs (rs174537, rs174546, rs174556, rs174601) in FADS

Conclusion This study showed that FADS1 genotype is distinguished by SAT fatty acid profiles, but not inflammatory gene expression.

Original languageEnglish
Pages (from-to)1539-1548
Number of pages10
JournalInternational Journal of Obesity
Issue number8
Publication statusPublished - Aug 2019


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