IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity

Keyphrases

• Tryptophan 100%
• Depressive Symptoms 100%
• Indoleamine 2,3-dioxygenase 1 (IDO1) 100%
• Neurotoxicity 100%
• Interferon-α (IFN-α) 100%
• Tryptophan Depletion 100%
• Kynurenine 62%
• Kynurenic Acid 37%
• Montgomery-asberg Depression Rating Scale 37%
• Netherlands 12%
• Neuroprotective 12%
• Inflammatory Cytokines 12%
• Pathophysiology 12%
• Maastricht University 12%
• Maastricht 12%
• Online Publication 12%
• Psychiatric Disorders 12%
• Kynurenine Pathway 12%
• Psychiatry 12%
• Blood-brain Barrier 12%
• High-performance Liquid Chromatography 12%
• Neuropsychology 12%
• Molecular Psychiatry 12%
• Amino Acid Score 12%
• Kynurenine Metabolites 12%
• Chronic Hepatitis C 12%
• Tryptophan Amino Acid 12%

INIS

• symptoms 100%
• tryptophan 100%
• hypothesis 100%
• interferon 100%
• kynurenine 63%
• availability 27%
• brain 27%
• metabolites 27%
• kynurenic acid 27%
• amino acids 18%
• induction 18%
• hepatitis 9%
• patients 9%
• assessments 9%
• netherlands 9%
• administration 9%
• production 9%
• cytokines 9%
• enzymes 9%
• universities 9%
• blood-brain barrier 9%
• high-performance liquid chromatography 9%

Neuroscience

• Tryptophan 100%
• Interferon Alfa 100%
• Indoleamine 2,3 Dioxygenase 100%
• Neurotoxicity 100%
• Depressive Disorder 100%
• Kynurenine 63%
• Kynurenic Acid 27%
• Amino Acid 18%
• Psychiatry 18%
• Proinflammatory Cytokine 9%
• Mental Disorder 9%
• Neuroprotective Agent 9%
• Neuropsychology 9%
• Blood Brain Barrier 9%
• Hepatitis C 9%