TY - JOUR
T1 - Identifying risk factors for COPD and adult-onset asthma
T2 - an umbrella review
AU - Holtjer, Judith C. S.
AU - Bloemsma, Lizan D.
AU - Beijers, Rosanne J. H. C. G.
AU - Cornelissen, Merel E. B.
AU - Hilvering, Bart
AU - Houweling, Laura
AU - Vermeulen, Roel C. H.
AU - Downward, George S.
AU - Maitland-Van der Zee, Anke-Hilse
AU - P4O2 Consortium
PY - 2023/6/30
Y1 - 2023/6/30
N2 - Background COPD and adult-onset asthma (AOA) are the most common noncommunicable respiratory diseases. To improve early identification and prevention, an overview of risk factors is needed. We therefore aimed to systematically summarise the nongenetic (exposome) risk factors for AOA and COPD. Additionally, we aimed to compare the risk factors for COPD and AOA. Methods In this umbrella review, we searched PubMed for articles from inception until 1 February 2023 and screened the references of relevant articles. We included systematic reviews and meta-analyses of observational epidemiological studies in humans that assessed a minimum of one lifestyle or environmental risk factor for AOA or COPD. Results In total, 75 reviews were included, of which 45 focused on risk factors for COPD, 28 on AOA and two examined both. For asthma, 43 different risk factors were identified while 45 were identified for COPD. For AOA, smoking, a high body mass index (BMI), wood dust exposure and residential chemical exposures, such as formaldehyde exposure or exposure to volatile organic compounds, were amongst the risk factors found. For COPD, smoking, ambient air pollution including nitrogen dioxide, a low BMI, indoor biomass burning, childhood asthma, occupational dust exposure and diet were amongst the risk factors found. Conclusions Many different factors for COPD and asthma have been found, highlighting the differences and similarities. The results of this systematic review can be used to target and identify people at high risk for COPD or AOA.
AB - Background COPD and adult-onset asthma (AOA) are the most common noncommunicable respiratory diseases. To improve early identification and prevention, an overview of risk factors is needed. We therefore aimed to systematically summarise the nongenetic (exposome) risk factors for AOA and COPD. Additionally, we aimed to compare the risk factors for COPD and AOA. Methods In this umbrella review, we searched PubMed for articles from inception until 1 February 2023 and screened the references of relevant articles. We included systematic reviews and meta-analyses of observational epidemiological studies in humans that assessed a minimum of one lifestyle or environmental risk factor for AOA or COPD. Results In total, 75 reviews were included, of which 45 focused on risk factors for COPD, 28 on AOA and two examined both. For asthma, 43 different risk factors were identified while 45 were identified for COPD. For AOA, smoking, a high body mass index (BMI), wood dust exposure and residential chemical exposures, such as formaldehyde exposure or exposure to volatile organic compounds, were amongst the risk factors found. For COPD, smoking, ambient air pollution including nitrogen dioxide, a low BMI, indoor biomass burning, childhood asthma, occupational dust exposure and diet were amongst the risk factors found. Conclusions Many different factors for COPD and asthma have been found, highlighting the differences and similarities. The results of this systematic review can be used to target and identify people at high risk for COPD or AOA.
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - ALLERGIC RHINITIS
KW - DIETARY PATTERNS
KW - AIR-POLLUTION
KW - METAANALYSIS
KW - EXPOSURE
KW - PREVALENCE
KW - BURDEN
KW - ASSOCIATION
KW - WORKERS
U2 - 10.1183/16000617.0009-2023
DO - 10.1183/16000617.0009-2023
M3 - (Systematic) Review article
C2 - 37137510
SN - 0905-9180
VL - 32
JO - European Respiratory Review
JF - European Respiratory Review
IS - 168
M1 - 230009
ER -