Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Francesco Marchetti; Marilyn J. Aardema; Carol Beevers; Jan van Benthem; Roger Godschalk; Andrew Williams; Carole L. Yauk; Robert Young; George R. Douglas

doi:10.1016/j.mrgentox.2018.05.021

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Francesco Marchetti^*, Marilyn J. Aardema, Carol Beevers, Jan van Benthem, Roger Godschalk, Andrew Williams, Carole L. Yauk, Robert Young, George R. Douglas

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	7-18
Number of pages	12
Journal	Mutation Research-Genetic Toxicology and Environmental Mutagenesis
Volume	832
DOIs	https://doi.org/10.1016/j.mrgentox.2018.05.021
Publication status	Published - Aug 2018

Keywords

Mutation
Germ cell
Transgene
Test guideline
Rodent
SPERMATOGONIAL STEM-CELLS
IN-VIVO MUTAGENICITY
BIG BLUE(R) MICE
METHYL METHANESULFONATE
ISOPROPYL METHANESULFONATE
INHALATION EXPOSURE
ETHYLENE-OXIDE
N-NITROSOUREA
MOUSE MODEL
LOCUS TEST

Cite this

Marchetti, F., Aardema, M. J., Beevers, C., van Benthem, J., Godschalk, R., Williams, A., Yauk, C. L., Young, R., & Douglas, G. R. (2018). Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 832, 7-18. https://doi.org/10.1016/j.mrgentox.2018.05.021

Marchetti, Francesco ; Aardema, Marilyn J. ; Beevers, Carol ; van Benthem, Jan ; Godschalk, Roger ; Williams, Andrew ; Yauk, Carole L. ; Young, Robert ; Douglas, George R. / Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. In: Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2018 ; Vol. 832. pp. 7-18.

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title = "Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing",

keywords = "Mutation, Germ cell, Transgene, Test guideline, Rodent, SPERMATOGONIAL STEM-CELLS, IN-VIVO MUTAGENICITY, BIG BLUE(R) MICE, METHYL METHANESULFONATE, ISOPROPYL METHANESULFONATE, INHALATION EXPOSURE, ETHYLENE-OXIDE, N-NITROSOUREA, MOUSE MODEL, LOCUS TEST",

author = "Francesco Marchetti and Aardema, {Marilyn J.} and Carol Beevers and {van Benthem}, Jan and Roger Godschalk and Andrew Williams and Yauk, {Carole L.} and Robert Young and Douglas, {George R.}",

year = "2018",

month = aug

doi = "10.1016/j.mrgentox.2018.05.021",

language = "English",

volume = "832",

pages = "7--18",

journal = "Mutation Research-Genetic Toxicology and Environmental Mutagenesis",

issn = "1383-5718",

publisher = "Elsevier",

}

Marchetti, F, Aardema, MJ, Beevers, C, van Benthem, J, Godschalk, R, Williams, A, Yauk, CL, Young, R & Douglas, GR 2018, 'Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing', Mutation Research-Genetic Toxicology and Environmental Mutagenesis, vol. 832, pp. 7-18. https://doi.org/10.1016/j.mrgentox.2018.05.021

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. / Marchetti, Francesco; Aardema, Marilyn J.; Beevers, Carol; van Benthem, Jan; Godschalk, Roger; Williams, Andrew; Yauk, Carole L.; Young, Robert; Douglas, George R.

In: Mutation Research-Genetic Toxicology and Environmental Mutagenesis, Vol. 832, 08.2018, p. 7-18.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

AU - Marchetti, Francesco

AU - Aardema, Marilyn J.

AU - Beevers, Carol

AU - van Benthem, Jan

AU - Godschalk, Roger

AU - Williams, Andrew

AU - Yauk, Carole L.

AU - Young, Robert

AU - Douglas, George R.

PY - 2018/8

Y1 - 2018/8

KW - Mutation

KW - Germ cell

KW - Transgene

KW - Test guideline

KW - Rodent

KW - SPERMATOGONIAL STEM-CELLS

KW - IN-VIVO MUTAGENICITY

KW - BIG BLUE(R) MICE

KW - METHYL METHANESULFONATE

KW - ISOPROPYL METHANESULFONATE

KW - INHALATION EXPOSURE

KW - ETHYLENE-OXIDE

KW - N-NITROSOUREA

KW - MOUSE MODEL

KW - LOCUS TEST

U2 - 10.1016/j.mrgentox.2018.05.021

DO - 10.1016/j.mrgentox.2018.05.021

M3 - Article

VL - 832

SP - 7

EP - 18

JO - Mutation Research-Genetic Toxicology and Environmental Mutagenesis

JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis

SN - 1383-5718

ER -

Marchetti F, Aardema MJ, Beevers C, van Benthem J, Godschalk R, Williams A et al. Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2018 Aug;832:7-18. https://doi.org/10.1016/j.mrgentox.2018.05.021

Access to Document

10.1016/j.mrgentox.2018.05.021