Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Francesco Marchetti; Marilyn J. Aardema; Carol Beevers; Jan van Benthem; Roger Godschalk; Andrew Williams; Carole L. Yauk; Robert Young; George R. Douglas

doi:10.1016/j.mrgentox.2018.05.021

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Francesco Marchetti^*, Marilyn J. Aardema, Carol Beevers, Jan van Benthem, Roger Godschalk, Andrew Williams, Carole L. Yauk, Robert Young, George R. Douglas

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	7-18
Number of pages	12
Journal	Mutation Research-Genetic Toxicology and Environmental Mutagenesis
Volume	832
DOIs	https://doi.org/10.1016/j.mrgentox.2018.05.021
Publication status	Published - Aug 2018

Keywords

Mutation
Germ cell
Transgene
Test guideline
Rodent
SPERMATOGONIAL STEM-CELLS
IN-VIVO MUTAGENICITY
BIG BLUE(R) MICE
METHYL METHANESULFONATE
ISOPROPYL METHANESULFONATE
INHALATION EXPOSURE
ETHYLENE-OXIDE
N-NITROSOUREA
MOUSE MODEL
LOCUS TEST

Access to Document

10.1016/j.mrgentox.2018.05.021

Research Output

1 Erratum / corrigendum

Corrigendum to "Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell Gene mutation assays) and integration with somatic cell testing" (vol 832, pg 7, 2018)

Marchetti, F., Aardema, M. J., Beevers, C., van Benthem, J., Godschalk, R., Williams, A., Yauk, C. L., Young, R. & Douglas, G. R., Aug 2019, In : Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 844, p. 70-71 2 p.

Research output: Contribution to journal › Erratum / corrigendum › Academic

Open Access

Cite this

Marchetti, F., Aardema, M. J., Beevers, C., van Benthem, J., Godschalk, R., Williams, A., Yauk, C. L., Young, R., & Douglas, G. R. (2018). Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 832, 7-18. https://doi.org/10.1016/j.mrgentox.2018.05.021

Marchetti, Francesco ; Aardema, Marilyn J. ; Beevers, Carol ; van Benthem, Jan ; Godschalk, Roger ; Williams, Andrew ; Yauk, Carole L. ; Young, Robert ; Douglas, George R. / Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. In: Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2018 ; Vol. 832. pp. 7-18.

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keywords = "Mutation, Germ cell, Transgene, Test guideline, Rodent, SPERMATOGONIAL STEM-CELLS, IN-VIVO MUTAGENICITY, BIG BLUE(R) MICE, METHYL METHANESULFONATE, ISOPROPYL METHANESULFONATE, INHALATION EXPOSURE, ETHYLENE-OXIDE, N-NITROSOUREA, MOUSE MODEL, LOCUS TEST",

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Marchetti, F, Aardema, MJ, Beevers, C, van Benthem, J, Godschalk, R, Williams, A, Yauk, CL, Young, R & Douglas, GR 2018, 'Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing', Mutation Research-Genetic Toxicology and Environmental Mutagenesis, vol. 832, pp. 7-18. https://doi.org/10.1016/j.mrgentox.2018.05.021

Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. / Marchetti, Francesco; Aardema, Marilyn J.; Beevers, Carol; van Benthem, Jan; Godschalk, Roger; Williams, Andrew; Yauk, Carole L.; Young, Robert; Douglas, George R.

In: Mutation Research-Genetic Toxicology and Environmental Mutagenesis, Vol. 832, 08.2018, p. 7-18.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Marchetti, Francesco

AU - Aardema, Marilyn J.

AU - Beevers, Carol

AU - van Benthem, Jan

AU - Godschalk, Roger

AU - Williams, Andrew

AU - Yauk, Carole L.

AU - Young, Robert

AU - Douglas, George R.

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KW - BIG BLUE(R) MICE

KW - METHYL METHANESULFONATE

KW - ISOPROPYL METHANESULFONATE

KW - INHALATION EXPOSURE

KW - ETHYLENE-OXIDE

KW - N-NITROSOUREA

KW - MOUSE MODEL

KW - LOCUS TEST

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JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis

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Marchetti F, Aardema MJ, Beevers C, van Benthem J, Godschalk R, Williams A et al. Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2018 Aug;832:7-18. https://doi.org/10.1016/j.mrgentox.2018.05.021