Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Francesco Marchetti*, Marilyn J. Aardema, Carol Beevers, Jan van Benthem, Roger Godschalk, Andrew Williams, Carole L. Yauk, Robert Young, George R. Douglas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)7-18
Number of pages12
JournalMutation Research-Genetic Toxicology and Environmental Mutagenesis
Volume832
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Mutation
  • Germ cell
  • Transgene
  • Test guideline
  • Rodent
  • SPERMATOGONIAL STEM-CELLS
  • IN-VIVO MUTAGENICITY
  • BIG BLUE(R) MICE
  • METHYL METHANESULFONATE
  • ISOPROPYL METHANESULFONATE
  • INHALATION EXPOSURE
  • ETHYLENE-OXIDE
  • N-NITROSOUREA
  • MOUSE MODEL
  • LOCUS TEST

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