Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

Francesco Marchetti*, Marilyn J. Aardema, Carol Beevers, Jan van Benthem, Roger Godschalk, Andrew Williams, Carole L. Yauk, Robert Young, George R. Douglas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)7-18
Number of pages12
JournalMutation Research-Genetic Toxicology and Environmental Mutagenesis
Volume832
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Mutation
  • Germ cell
  • Transgene
  • Test guideline
  • Rodent
  • SPERMATOGONIAL STEM-CELLS
  • IN-VIVO MUTAGENICITY
  • BIG BLUE(R) MICE
  • METHYL METHANESULFONATE
  • ISOPROPYL METHANESULFONATE
  • INHALATION EXPOSURE
  • ETHYLENE-OXIDE
  • N-NITROSOUREA
  • MOUSE MODEL
  • LOCUS TEST

Cite this

Marchetti, Francesco ; Aardema, Marilyn J. ; Beevers, Carol ; van Benthem, Jan ; Godschalk, Roger ; Williams, Andrew ; Yauk, Carole L. ; Young, Robert ; Douglas, George R. / Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. In: Mutation Research-Genetic Toxicology and Environmental Mutagenesis. 2018 ; Vol. 832. pp. 7-18.
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title = "Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing",
keywords = "Mutation, Germ cell, Transgene, Test guideline, Rodent, SPERMATOGONIAL STEM-CELLS, IN-VIVO MUTAGENICITY, BIG BLUE(R) MICE, METHYL METHANESULFONATE, ISOPROPYL METHANESULFONATE, INHALATION EXPOSURE, ETHYLENE-OXIDE, N-NITROSOUREA, MOUSE MODEL, LOCUS TEST",
author = "Francesco Marchetti and Aardema, {Marilyn J.} and Carol Beevers and {van Benthem}, Jan and Roger Godschalk and Andrew Williams and Yauk, {Carole L.} and Robert Young and Douglas, {George R.}",
year = "2018",
month = "8",
doi = "10.1016/j.mrgentox.2018.05.021",
language = "English",
volume = "832",
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journal = "Mutation Research-Genetic Toxicology and Environmental Mutagenesis",
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Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing. / Marchetti, Francesco; Aardema, Marilyn J.; Beevers, Carol; van Benthem, Jan; Godschalk, Roger; Williams, Andrew; Yauk, Carole L.; Young, Robert; Douglas, George R.

In: Mutation Research-Genetic Toxicology and Environmental Mutagenesis, Vol. 832, 08.2018, p. 7-18.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing

AU - Marchetti, Francesco

AU - Aardema, Marilyn J.

AU - Beevers, Carol

AU - van Benthem, Jan

AU - Godschalk, Roger

AU - Williams, Andrew

AU - Yauk, Carole L.

AU - Young, Robert

AU - Douglas, George R.

PY - 2018/8

Y1 - 2018/8

KW - Mutation

KW - Germ cell

KW - Transgene

KW - Test guideline

KW - Rodent

KW - SPERMATOGONIAL STEM-CELLS

KW - IN-VIVO MUTAGENICITY

KW - BIG BLUE(R) MICE

KW - METHYL METHANESULFONATE

KW - ISOPROPYL METHANESULFONATE

KW - INHALATION EXPOSURE

KW - ETHYLENE-OXIDE

KW - N-NITROSOUREA

KW - MOUSE MODEL

KW - LOCUS TEST

U2 - 10.1016/j.mrgentox.2018.05.021

DO - 10.1016/j.mrgentox.2018.05.021

M3 - Article

VL - 832

SP - 7

EP - 18

JO - Mutation Research-Genetic Toxicology and Environmental Mutagenesis

JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis

SN - 1383-5718

ER -