Abstract
Original language | English |
---|---|
Pages (from-to) | 729-736 |
Journal | Schizophrenia Bulletin |
Volume | 40 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 2014 |
Keywords
- schizophrenia
- gene-environment interaction
- psychosis
- epidemiology
- genetics
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In: Schizophrenia Bulletin, Vol. 40, No. 4, 07.2014, p. 729-736.
Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations
AU - van Os, Jim
AU - Rutten, Bart P.
AU - Myin-Germeys, Inez
AU - Delespaul, Philippe
AU - Viechtbauer, Wolfgang
AU - van Zelst, Catherine
AU - Bruggeman, Richard
AU - Reininghaus, Ulrich
AU - Morgan, Craig
AU - Murray, Robin M.
AU - Di Forti, Marta
AU - McGuire, Philip
AU - Valmaggia, Lucia R.
AU - Kempton, Matthew J.
AU - Gayer-Anderson, Charlotte
AU - Hubbard, Kathryn
AU - Beards, Stephanie
AU - Stilo, Simona A.
AU - Onyejiaka, Adanna
AU - Bourque, Francois
AU - Modinos, Gemma
AU - Tognin, Stefania
AU - Calem, Maria
AU - O'Donovan, Michael C.
AU - Owen, Michael J.
AU - Holmans, Peter
AU - Williams, Nigel
AU - Craddock, Nicholas
AU - Richards, Alexander
AU - Humphreys, Isla
AU - Meyer-Lindenberg, Andreas
AU - Leweke, F. Markus
AU - Tost, Heike
AU - Akdeniz, Ceren
AU - Rohleder, Cathrin
AU - Bumb, J. Malte
AU - Schwarz, Emanuel
AU - Alptekin, Koksal
AU - Ucok, Alp
AU - Saka, Meram Can
AU - Atbasoglu, E. Cem
AU - Guloksuz, Sinan
AU - Gumus-Akay, Guvem
AU - Cihan, Burin
AU - Karadag, Hasan
AU - Soygur, Haldan
AU - Cankurtaran, Eylem Sahin
AU - Ulusoy, Semra
AU - Akdede, Berna
AU - Binbay, Tolga
AU - Ayer, Ahmet
AU - Noyan, Handan
AU - Karadayi, Gulsah
AU - Akturan, Elin
AU - Ulas, Halis
AU - Arango, Celso
AU - Parellada, Mara
AU - Bernardo, Miguel
AU - Sanjuan, Julio
AU - Bobes, Julio
AU - Arrojo, Manuel
AU - Luis Santos, Jose
AU - Cuadrado, Pedro
AU - Rodriguez Solano, Jose Juan
AU - Carracedo, Angel
AU - Garcia Bernardo, Enrique
AU - Roldan, Laura
AU - Lopez, Gonzalo
AU - Cabrera, Bibiana
AU - Cruz, Sabrina
AU - Diaz Mesa, Eva Ma
AU - Pouso, Maria
AU - Jimenez, Estela
AU - Sanchez, Teresa
AU - Rapado, Marta
AU - Gonzalez, Emiliano
AU - Martinez, Covadonga
AU - Sanchez, Emilio
AU - Soledad Olmeda, Ma
AU - de Haan, Lieuwe
AU - Velthorst, Eva
AU - van der Gaag, Mark
AU - Selten, Jean-Paul
AU - van Dam, Daniella
AU - van der Ven, Elsje
AU - van der Meer, Floor
AU - Messchaert, Elles
AU - Kraan, Tamar
AU - Burger, Nadine
AU - Leboyer, Marion
AU - Szoke, Andrei
AU - Schurhoff, Franck
AU - Llorca, Pierre-Michel
AU - Jamain, Stephane
AU - Tortelli, Andrea
AU - Frijda, Flora
AU - Vilain, Jeanne
AU - Galliot, Anne-Marie
AU - Baudin, Gregoire
AU - Ferchiou, Aziz
AU - Richard, Jean-Romain
AU - Bulzacka, Ewa
AU - Charpeaud, Thomas
AU - Tronche, Anne-Marie
AU - De Hert, Marc
AU - van Winkel, Ruud
AU - Decoster, Jeroen
AU - Derom, Catherine
AU - Thiery, Evert
AU - Stefanis, Nikos C.
AU - Sachs, Gabriele
AU - Aschauer, Harald
AU - Lasser, Iris
AU - Winklbaur, Bernadette
AU - Schlogelhofer, Monika
AU - Riecher-Rossler, Anita
AU - Borgwardt, Stefan
AU - Walter, Anna
AU - Harrisberger, Fabienne
AU - Smieskova, Renata
AU - Rapp, Charlotte
AU - Ittig, Sarah
AU - Soguel-Dit-Piquard, Fabienne
AU - Studerus, Erich
AU - Klosterkotter, Joachim
AU - Ruhrmann, Stephan
AU - Paruch, Julia
AU - Julkowski, Dominika
AU - Hilboll, Desiree
AU - Sham, Pak C.
AU - Cherny, Stacey S.
AU - Chen, Eric Y. H.
AU - Campbell, Desmond D.
AU - Li, Miaoxin
AU - Maria Romeo-Casabona, Carlos
AU - Emaldi Cirion, Aitziber
AU - Urruela Mora, Asier
AU - Jones, Peter
AU - Kirkbride, James
AU - Cannon, Mary
AU - Rujescu, Dan
AU - Tarricone, Ilaria
AU - Berardi, Domenico
AU - Bonora, Elena
AU - Seri, Marco
AU - Marcacci, Thomas
AU - Chiri, Luigi
AU - Chierzi, Federico
AU - Storbini, Viviana
AU - Braca, Mauro
AU - Minenna, Maria Gabriella
AU - Donegani, Ivonne
AU - Fioritti, Angelo
AU - La Barbera, Daniele
AU - La Cascia, Caterina Erika
AU - Mule, Alice
AU - Sideli, Lucia
AU - Sartorio, Rachele
AU - Ferraro, Laura
AU - Tripoli, Giada
AU - Seminerio, Fabio
AU - Marinaro, Anna Maria
AU - McGorry, Patrick
AU - Nelson, Barnaby
AU - Amminger, G. Paul
AU - Pantelis, Christos
AU - Menezes, Paulo R.
AU - Del-Ben, Cristina M.
AU - Tenan, Silvia H. Gallo
AU - Shuhama, Rosana
AU - Ruggeri, Mirella
AU - Tosato, Sarah
AU - Lasalvia, Antonio
AU - Bonetto, Chiara
AU - Ira, Elisa
AU - Nordentoft, Merete
AU - Krebs, Marie-Odile
AU - Barrantes-Vidal, Neus
AU - Cristobal, Paula
AU - Kwapil, Thomas R.
AU - Brietzke, Elisa
AU - Bressan, Rodrigo A.
AU - Gadelha, Ary
AU - Maric, Nadja P.
AU - Andric, Sanja
AU - Mihaljevic, Marina
AU - Mirjanic, Tijana
PY - 2014/7
Y1 - 2014/7
N2 - Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
AB - Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
KW - schizophrenia
KW - gene-environment interaction
KW - psychosis
KW - epidemiology
KW - genetics
U2 - 10.1093/schbul/sbu069
DO - 10.1093/schbul/sbu069
M3 - Article
C2 - 24860087
SN - 0586-7614
VL - 40
SP - 729
EP - 736
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 4
ER -