Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

R.A. Eeles; Z. Kote Jarai; A.A. Al Olama; G.G. Giles; M. Guy; G. Severi; K. Muir; J.L. Hopper; B.E. Henderson; C.A. Haiman; J. Schleutker; F.C. Hamdy; D.E. Neal; J.L. Donovan; J.L. Stanford; E.A. Ostrander; S.A. Ingles; E.M. John; S.N. Thibodeau; D. Schaid; J.Y. Park; A. Spurdle; J. Clements; J.L. Dickinson; C. Maier; W. Vogel; T. Dork; T.R. Rebbeck; K.A. Cooney; L. Cannon Albright; P.O. Chappuis; P. Hutter; M. Zeegers; R. Kaneva; H.W. Zhang; Y.J. Lu; WD. Foulkes; D.R. English; D.A. Leongamornlert; M. Tymrakiewicz; J. Morrison; A.T. Ardern Jones; A.L. Hall; L.T. O'Brien; R.A. Wilkinson; E.J. Saunders; E.C. Page; E.J. Sawyer; S.M. Edwards; D.P. Dearnaley; A. Horwich; R.A. Huddart; V.S. Khoo; C.C. Parker; N. Van As; C.J. Woodhouse; A. Thompson; T. Christmas; C. Ogden; C.S. Cooper; M.C. Southey; A. Lophatananon; J.F. Liu; L.N. Kolonel; L. Le Marchand; T. Wahlfors; T.L. Tammela; A. Auvinen; S.J. Lewis; A. Cox; L.M. FitzGerald; J.S. Koopmeiners; D.M. Karyadi; E.M. Kwon; M.C. Stern; R. Corral; A.D. Joshi; A. Shahabi; S.K. McDonnell; T.A. Sellers; J. Pow Sang; S. Chambers; J. Aitken; R.A. Gardiner; J. Batra; M.A. Kedda; F. Lose; A. Polanowski; B. Patterson; J. Serth; A. Meyer; M. Luedeke; K. Stefflova; A.M. Ray; E.M. Lange; J. Farnham; H. Khan; C. Slavov; A. Mitkova

doi:10.1038/ng.450

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

R.A. Eeles^*, Z. Kote Jarai, A.A. Al Olama, G.G. Giles, M. Guy, G. Severi, K. Muir, J.L. Hopper, B.E. Henderson, C.A. Haiman, J. Schleutker, F.C. Hamdy, D.E. Neal, J.L. Donovan, J.L. Stanford, E.A. Ostrander, S.A. Ingles, E.M. John, S.N. Thibodeau, D. SchaidJ.Y. Park, A. Spurdle, J. Clements, J.L. Dickinson, C. Maier, W. Vogel, T. Dork, T.R. Rebbeck, K.A. Cooney, L. Cannon Albright, P.O. Chappuis, P. Hutter, M. Zeegers, R. Kaneva, H.W. Zhang, Y.J. Lu, WD. Foulkes, D.R. English, D.A. Leongamornlert, M. Tymrakiewicz, J. Morrison, A.T. Ardern Jones, A.L. Hall, L.T. O'Brien, R.A. Wilkinson, E.J. Saunders, E.C. Page, E.J. Sawyer, S.M. Edwards, D.P. Dearnaley, A. Horwich, R.A. Huddart, V.S. Khoo, C.C. Parker, N. Van As, C.J. Woodhouse, A. Thompson, T. Christmas, C. Ogden, C.S. Cooper, M.C. Southey, A. Lophatananon, J.F. Liu, L.N. Kolonel, L. Le Marchand, T. Wahlfors, T.L. Tammela, A. Auvinen, S.J. Lewis, A. Cox, L.M. FitzGerald, J.S. Koopmeiners, D.M. Karyadi, E.M. Kwon, M.C. Stern, R. Corral, A.D. Joshi, A. Shahabi, S.K. McDonnell, T.A. Sellers, J. Pow Sang, S. Chambers, J. Aitken, R.A. Gardiner, J. Batra, M.A. Kedda, F. Lose, A. Polanowski, B. Patterson, J. Serth, A. Meyer, M. Luedeke, K. Stefflova, A.M. Ray, E.M. Lange, J. Farnham, H. Khan, C. Slavov, A. Mitkova

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).

Original language	English
Pages (from-to)	1116-21
Journal	Nature Genetics
Volume	41
Issue number	10
DOIs	https://doi.org/10.1038/ng.450
Publication status	Published - 1 Jan 2009

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10.1038/ng.450

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Eeles, R. A., Kote Jarai, Z., Al Olama, A. A., Giles, G. G., Guy, M., Severi, G., Muir, K., Hopper, J. L., Henderson, B. E., Haiman, C. A., Schleutker, J., Hamdy, F. C., Neal, D. E., Donovan, J. L., Stanford, J. L., Ostrander, E. A., Ingles, S. A., John, E. M., Thibodeau, S. N., ... Mitkova, A. (2009). Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nature Genetics, 41(10), 1116-21. https://doi.org/10.1038/ng.450

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title = "Identification of seven new prostate cancer susceptibility loci through a genome-wide association study",

abstract = "Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).",

author = "R.A. Eeles and {Kote Jarai}, Z. and {Al Olama}, A.A. and G.G. Giles and M. Guy and G. Severi and K. Muir and J.L. Hopper and B.E. Henderson and C.A. Haiman and J. Schleutker and F.C. Hamdy and D.E. Neal and J.L. Donovan and J.L. Stanford and E.A. Ostrander and S.A. Ingles and E.M. John and S.N. Thibodeau and D. Schaid and J.Y. Park and A. Spurdle and J. Clements and J.L. Dickinson and C. Maier and W. Vogel and T. Dork and T.R. Rebbeck and K.A. Cooney and {Cannon Albright}, L. and P.O. Chappuis and P. Hutter and M. Zeegers and R. Kaneva and H.W. Zhang and Y.J. Lu and WD. Foulkes and D.R. English and D.A. Leongamornlert and M. Tymrakiewicz and J. Morrison and {Ardern Jones}, A.T. and A.L. Hall and L.T. O'Brien and R.A. Wilkinson and E.J. Saunders and E.C. Page and E.J. Sawyer and S.M. Edwards and D.P. Dearnaley and A. Horwich and R.A. Huddart and V.S. Khoo and C.C. Parker and {Van As}, N. and C.J. Woodhouse and A. Thompson and T. Christmas and C. Ogden and C.S. Cooper and M.C. Southey and A. Lophatananon and J.F. Liu and L.N. Kolonel and {Le Marchand}, L. and T. Wahlfors and T.L. Tammela and A. Auvinen and S.J. Lewis and A. Cox and L.M. FitzGerald and J.S. Koopmeiners and D.M. Karyadi and E.M. Kwon and M.C. Stern and R. Corral and A.D. Joshi and A. Shahabi and S.K. McDonnell and T.A. Sellers and {Pow Sang}, J. and S. Chambers and J. Aitken and R.A. Gardiner and J. Batra and M.A. Kedda and F. Lose and A. Polanowski and B. Patterson and J. Serth and A. Meyer and M. Luedeke and K. Stefflova and A.M. Ray and E.M. Lange and J. Farnham and H. Khan and C. Slavov and A. Mitkova",

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doi = "10.1038/ng.450",

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volume = "41",

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Eeles, RA, Kote Jarai, Z, Al Olama, AA, Giles, GG, Guy, M, Severi, G, Muir, K, Hopper, JL, Henderson, BE, Haiman, CA, Schleutker, J, Hamdy, FC, Neal, DE, Donovan, JL, Stanford, JL, Ostrander, EA, Ingles, SA, John, EM, Thibodeau, SN, Schaid, D, Park, JY, Spurdle, A, Clements, J, Dickinson, JL, Maier, C, Vogel, W, Dork, T, Rebbeck, TR, Cooney, KA, Cannon Albright, L, Chappuis, PO, Hutter, P, Zeegers, M, Kaneva, R, Zhang, HW, Lu, YJ, Foulkes, WD, English, DR, Leongamornlert, DA, Tymrakiewicz, M, Morrison, J, Ardern Jones, AT, Hall, AL, O'Brien, LT, Wilkinson, RA, Saunders, EJ, Page, EC, Sawyer, EJ, Edwards, SM, Dearnaley, DP, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Van As, N, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Cooper, CS, Southey, MC, Lophatananon, A, Liu, JF, Kolonel, LN, Le Marchand, L, Wahlfors, T, Tammela, TL, Auvinen, A, Lewis, SJ, Cox, A, FitzGerald, LM, Koopmeiners, JS, Karyadi, DM, Kwon, EM, Stern, MC, Corral, R, Joshi, AD, Shahabi, A, McDonnell, SK, Sellers, TA, Pow Sang, J, Chambers, S, Aitken, J, Gardiner, RA, Batra, J, Kedda, MA, Lose, F, Polanowski, A, Patterson, B, Serth, J, Meyer, A, Luedeke, M, Stefflova, K, Ray, AM, Lange, EM, Farnham, J, Khan, H, Slavov, C & Mitkova, A 2009, 'Identification of seven new prostate cancer susceptibility loci through a genome-wide association study', Nature Genetics, vol. 41, no. 10, pp. 1116-21. https://doi.org/10.1038/ng.450

TY - JOUR

T1 - Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

AU - Eeles, R.A.

AU - Kote Jarai, Z.

AU - Al Olama, A.A.

AU - Giles, G.G.

AU - Guy, M.

AU - Severi, G.

AU - Muir, K.

AU - Hopper, J.L.

AU - Henderson, B.E.

AU - Haiman, C.A.

AU - Schleutker, J.

AU - Hamdy, F.C.

AU - Neal, D.E.

AU - Donovan, J.L.

AU - Stanford, J.L.

AU - Ostrander, E.A.

AU - Ingles, S.A.

AU - John, E.M.

AU - Thibodeau, S.N.

AU - Schaid, D.

AU - Park, J.Y.

AU - Spurdle, A.

AU - Clements, J.

AU - Dickinson, J.L.

AU - Maier, C.

AU - Vogel, W.

AU - Dork, T.

AU - Rebbeck, T.R.

AU - Cooney, K.A.

AU - Cannon Albright, L.

AU - Chappuis, P.O.

AU - Hutter, P.

AU - Zeegers, M.

AU - Kaneva, R.

AU - Zhang, H.W.

AU - Lu, Y.J.

AU - Foulkes, WD.

AU - English, D.R.

AU - Leongamornlert, D.A.

AU - Tymrakiewicz, M.

AU - Morrison, J.

AU - Ardern Jones, A.T.

AU - Hall, A.L.

AU - O'Brien, L.T.

AU - Wilkinson, R.A.

AU - Saunders, E.J.

AU - Page, E.C.

AU - Sawyer, E.J.

AU - Edwards, S.M.

AU - Dearnaley, D.P.

AU - Horwich, A.

AU - Huddart, R.A.

AU - Khoo, V.S.

AU - Parker, C.C.

AU - Van As, N.

AU - Woodhouse, C.J.

AU - Thompson, A.

AU - Christmas, T.

AU - Ogden, C.

AU - Cooper, C.S.

AU - Southey, M.C.

AU - Lophatananon, A.

AU - Liu, J.F.

AU - Kolonel, L.N.

AU - Le Marchand, L.

AU - Wahlfors, T.

AU - Tammela, T.L.

AU - Auvinen, A.

AU - Lewis, S.J.

AU - Cox, A.

AU - FitzGerald, L.M.

AU - Koopmeiners, J.S.

AU - Karyadi, D.M.

AU - Kwon, E.M.

AU - Stern, M.C.

AU - Corral, R.

AU - Joshi, A.D.

AU - Shahabi, A.

AU - McDonnell, S.K.

AU - Sellers, T.A.

AU - Pow Sang, J.

AU - Chambers, S.

AU - Aitken, J.

AU - Gardiner, R.A.

AU - Batra, J.

AU - Kedda, M.A.

AU - Lose, F.

AU - Polanowski, A.

AU - Patterson, B.

AU - Serth, J.

AU - Meyer, A.

AU - Luedeke, M.

AU - Stefflova, K.

AU - Ray, A.M.

AU - Lange, E.M.

AU - Farnham, J.

AU - Khan, H.

AU - Slavov, C.

AU - Mitkova, A.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).

AB - Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).

U2 - 10.1038/ng.450

DO - 10.1038/ng.450

M3 - Article

C2 - 19767753

SN - 1061-4036

VL - 41

SP - 1116

EP - 1121

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -