TY - JOUR
T1 - Identification of Hidden Key Hepatitis C Populations: An Evaluation of Screening Practices Using Mixed Epidemiological Methods
AU - Vermeiren, Angelique P. A.
AU - Dukers-Muijrers, Nicole H.T.M.
AU - van Loo, Inge H. M.
AU - Stals, Frans
AU - van Dam, Dirk W.
AU - Ambergen, Ton
AU - Hoebe, Christian J. P. A.
PY - 2012/12/7
Y1 - 2012/12/7
N2 - Background: Hepatitis C virus (HCV) is a major cause of liver diseases worldwide. Due to its asymptomatic nature, screening is necessary for identification. Because screening of the total population is not cost effective, it is important to identify which risk factors for positivity characterize the key populations in which targeting of screening yields the highest numbers of HCV positives, and assess which of these key populations have remained hidden to current care. Methods: Laboratory registry data (2002-2008) were retrieved for all HCV tests (23,800) in the south of the Netherlands (adult population 500,000). Screening trends were tested using Poisson regression and chi-square tests. Risk factors for HCV positivity were assessed using a logistic regression. The hidden HCV-positive population was estimated by a capture-recapture approach. Results: The number of tests increased over time (2,388 to 4,149, p
AB - Background: Hepatitis C virus (HCV) is a major cause of liver diseases worldwide. Due to its asymptomatic nature, screening is necessary for identification. Because screening of the total population is not cost effective, it is important to identify which risk factors for positivity characterize the key populations in which targeting of screening yields the highest numbers of HCV positives, and assess which of these key populations have remained hidden to current care. Methods: Laboratory registry data (2002-2008) were retrieved for all HCV tests (23,800) in the south of the Netherlands (adult population 500,000). Screening trends were tested using Poisson regression and chi-square tests. Risk factors for HCV positivity were assessed using a logistic regression. The hidden HCV-positive population was estimated by a capture-recapture approach. Results: The number of tests increased over time (2,388 to 4,149, p
U2 - 10.1371/journal.pone.0051194
DO - 10.1371/journal.pone.0051194
M3 - Article
C2 - 23236452
SN - 1932-6203
VL - 7
JO - PLOS ONE
JF - PLOS ONE
IS - 12
M1 - e51194
ER -