IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Yukihide Momozawa, Julia Dmitrieva, Emilie Theatre, Valerie Deffontaine, Souad Rahmouni, Benoit Charloteaux, Francois Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cecile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd Bouma, Frank HoentjenMark Lowenberg, Bas Oldenburg, Marieke J. Pierik, Andrea E. vander Meulen-de Jong, C. Janneke van der Woude, Marijn C. Visschedijk, Mark Lathrop, Jean-Pierre Hugot, Rinse K. Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges, Clara Abraham, Jean-Paul Achkar, Tariq Ahmad, Ashwin N. Ananthakrishnan, Vibeke Andersen, Carl A. Anderson, Jane M. Andrews, Vito Annese, Guy Aumais, Leonard Baidoo, Robert N. Baldassano, Peter A. Bampton, Stephan Brand, Dirk De Jong, Hu Zhang, Int IBD Genetics Consortium

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number2427
Number of pages18
JournalNature Communications
Volume9
DOIs
Publication statusPublished - 21 Jun 2018

Keywords

  • INFLAMMATORY-BOWEL-DISEASE
  • GENOME-WIDE ASSOCIATION
  • QUANTITATIVE TRAIT LOCUS
  • RARE VARIANTS
  • LOW-FREQUENCY
  • CODING VARIANTS
  • SEQUENCING DATA
  • CROHNS-DISEASE
  • COMPLEX TRAITS
  • SUSCEPTIBILITY
  • Humans
  • Middle Aged
  • Male
  • Gene Expression Profiling
  • Multifactorial Inheritance
  • Aged, 80 and over
  • Adult
  • Female
  • Crohn Disease/genetics
  • Genetic Predisposition to Disease
  • Genetic Association Studies
  • Genotype
  • Sequence Analysis, DNA
  • Aged
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • Cohort Studies
  • Inflammatory Bowel Diseases/genetics

Cite this