IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

, Yukihide Momozawa, Julia Dmitrieva, Emilie Theatre, Valerie Deffontaine, Souad Rahmouni, Benoit Charloteaux, Francois Crins, Elisa Docampo, Mahmoud Elansary, Ann-Stephan Gori, Christelle Lecut, Rob Mariman, Myriam Mni, Cecile Oury, Ilya Altukhov, Dmitry Alexeev, Yuri Aulchenko, Leila Amininejad, Gerd BoumaFrank Hoentjen, Mark Lowenberg, Bas Oldenburg, Marieke J. Pierik, Andrea E. vander Meulen-de Jong, C. Janneke van der Woude, Marijn C. Visschedijk, Mark Lathrop, Jean-Pierre Hugot, Rinse K. Weersma, Martine De Vos, Denis Franchimont, Severine Vermeire, Michiaki Kubo, Edouard Louis, Michel Georges, Clara Abraham, Jean-Paul Achkar, Tariq Ahmad, Ashwin N. Ananthakrishnan, Vibeke Andersen, Carl A. Anderson, Jane M. Andrews, Vito Annese, Guy Aumais, Leonard Baidoo, Robert N. Baldassano, Peter A. Bampton, Stephan Brand, Dirk De Jong, Hu Zhang

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number2427
Number of pages18
JournalNature Communications
Volume9
DOIs
Publication statusPublished - 21 Jun 2018

Keywords

  • INFLAMMATORY-BOWEL-DISEASE
  • GENOME-WIDE ASSOCIATION
  • QUANTITATIVE TRAIT LOCUS
  • RARE VARIANTS
  • LOW-FREQUENCY
  • CODING VARIANTS
  • SEQUENCING DATA
  • CROHNS-DISEASE
  • COMPLEX TRAITS
  • SUSCEPTIBILITY
  • Humans
  • Middle Aged
  • Male
  • Gene Expression Profiling
  • Multifactorial Inheritance
  • Aged, 80 and over
  • Adult
  • Female
  • Crohn Disease/genetics
  • Genetic Predisposition to Disease
  • Genetic Association Studies
  • Genotype
  • Sequence Analysis, DNA
  • Aged
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • Cohort Studies
  • Inflammatory Bowel Diseases/genetics

Cite this

, Momozawa, Y., Dmitrieva, J., Theatre, E., Deffontaine, V., Rahmouni, S., ... Zhang, H. (2018). IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nature Communications, 9, [2427]. https://doi.org/10.1038/s41467-018-04365-8
Momozawa, Yukihide ; Dmitrieva, Julia ; Theatre, Emilie ; Deffontaine, Valerie ; Rahmouni, Souad ; Charloteaux, Benoit ; Crins, Francois ; Docampo, Elisa ; Elansary, Mahmoud ; Gori, Ann-Stephan ; Lecut, Christelle ; Mariman, Rob ; Mni, Myriam ; Oury, Cecile ; Altukhov, Ilya ; Alexeev, Dmitry ; Aulchenko, Yuri ; Amininejad, Leila ; Bouma, Gerd ; Hoentjen, Frank ; Lowenberg, Mark ; Oldenburg, Bas ; Pierik, Marieke J. ; vander Meulen-de Jong, Andrea E. ; van der Woude, C. Janneke ; Visschedijk, Marijn C. ; Lathrop, Mark ; Hugot, Jean-Pierre ; Weersma, Rinse K. ; De Vos, Martine ; Franchimont, Denis ; Vermeire, Severine ; Kubo, Michiaki ; Louis, Edouard ; Georges, Michel ; Abraham, Clara ; Achkar, Jean-Paul ; Ahmad, Tariq ; Ananthakrishnan, Ashwin N. ; Andersen, Vibeke ; Anderson, Carl A. ; Andrews, Jane M. ; Annese, Vito ; Aumais, Guy ; Baidoo, Leonard ; Baldassano, Robert N. ; Bampton, Peter A. ; Brand, Stephan ; De Jong, Dirk ; Zhang, Hu. / IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. In: Nature Communications. 2018 ; Vol. 9.
@article{bc2341b2d3da4a439faea4f70bd5b2ee,
title = "IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes",
keywords = "INFLAMMATORY-BOWEL-DISEASE, GENOME-WIDE ASSOCIATION, QUANTITATIVE TRAIT LOCUS, RARE VARIANTS, LOW-FREQUENCY, CODING VARIANTS, SEQUENCING DATA, CROHNS-DISEASE, COMPLEX TRAITS, SUSCEPTIBILITY, Humans, Middle Aged, Male, Gene Expression Profiling, Multifactorial Inheritance, Aged, 80 and over, Adult, Female, Crohn Disease/genetics, Genetic Predisposition to Disease, Genetic Association Studies, Genotype, Sequence Analysis, DNA, Aged, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Cohort Studies, Inflammatory Bowel Diseases/genetics",
author = "Yukihide Momozawa and Julia Dmitrieva and Emilie Theatre and Valerie Deffontaine and Souad Rahmouni and Benoit Charloteaux and Francois Crins and Elisa Docampo and Mahmoud Elansary and Ann-Stephan Gori and Christelle Lecut and Rob Mariman and Myriam Mni and Cecile Oury and Ilya Altukhov and Dmitry Alexeev and Yuri Aulchenko and Leila Amininejad and Gerd Bouma and Frank Hoentjen and Mark Lowenberg and Bas Oldenburg and Pierik, {Marieke J.} and {vander Meulen-de Jong}, {Andrea E.} and {van der Woude}, {C. Janneke} and Visschedijk, {Marijn C.} and Mark Lathrop and Jean-Pierre Hugot and Weersma, {Rinse K.} and {De Vos}, Martine and Denis Franchimont and Severine Vermeire and Michiaki Kubo and Edouard Louis and Michel Georges and Clara Abraham and Jean-Paul Achkar and Tariq Ahmad and Ananthakrishnan, {Ashwin N.} and Vibeke Andersen and Anderson, {Carl A.} and Andrews, {Jane M.} and Vito Annese and Guy Aumais and Leonard Baidoo and Baldassano, {Robert N.} and Bampton, {Peter A.} and Stephan Brand and {De Jong}, Dirk and Hu Zhang",
year = "2018",
month = "6",
day = "21",
doi = "10.1038/s41467-018-04365-8",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

Momozawa, Y, Dmitrieva, J, Theatre, E, Deffontaine, V, Rahmouni, S, Charloteaux, B, Crins, F, Docampo, E, Elansary, M, Gori, A-S, Lecut, C, Mariman, R, Mni, M, Oury, C, Altukhov, I, Alexeev, D, Aulchenko, Y, Amininejad, L, Bouma, G, Hoentjen, F, Lowenberg, M, Oldenburg, B, Pierik, MJ, vander Meulen-de Jong, AE, van der Woude, CJ, Visschedijk, MC, Lathrop, M, Hugot, J-P, Weersma, RK, De Vos, M, Franchimont, D, Vermeire, S, Kubo, M, Louis, E, Georges, M, Abraham, C, Achkar, J-P, Ahmad, T, Ananthakrishnan, AN, Andersen, V, Anderson, CA, Andrews, JM, Annese, V, Aumais, G, Baidoo, L, Baldassano, RN, Bampton, PA, Brand, S & De Jong, D & Zhang, H 2018, 'IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes', Nature Communications, vol. 9, 2427. https://doi.org/10.1038/s41467-018-04365-8

IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. /; Momozawa, Yukihide; Dmitrieva, Julia; Theatre, Emilie; Deffontaine, Valerie; Rahmouni, Souad; Charloteaux, Benoit; Crins, Francois; Docampo, Elisa; Elansary, Mahmoud; Gori, Ann-Stephan; Lecut, Christelle; Mariman, Rob; Mni, Myriam; Oury, Cecile; Altukhov, Ilya; Alexeev, Dmitry; Aulchenko, Yuri; Amininejad, Leila; Bouma, Gerd; Hoentjen, Frank; Lowenberg, Mark; Oldenburg, Bas; Pierik, Marieke J.; vander Meulen-de Jong, Andrea E.; van der Woude, C. Janneke; Visschedijk, Marijn C.; Lathrop, Mark; Hugot, Jean-Pierre; Weersma, Rinse K.; De Vos, Martine; Franchimont, Denis; Vermeire, Severine; Kubo, Michiaki; Louis, Edouard; Georges, Michel; Abraham, Clara; Achkar, Jean-Paul; Ahmad, Tariq; Ananthakrishnan, Ashwin N.; Andersen, Vibeke; Anderson, Carl A.; Andrews, Jane M.; Annese, Vito; Aumais, Guy; Baidoo, Leonard; Baldassano, Robert N.; Bampton, Peter A.; Brand, Stephan; De Jong, Dirk; Zhang, Hu.

In: Nature Communications, Vol. 9, 2427, 21.06.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

AU - Momozawa, Yukihide

AU - Dmitrieva, Julia

AU - Theatre, Emilie

AU - Deffontaine, Valerie

AU - Rahmouni, Souad

AU - Charloteaux, Benoit

AU - Crins, Francois

AU - Docampo, Elisa

AU - Elansary, Mahmoud

AU - Gori, Ann-Stephan

AU - Lecut, Christelle

AU - Mariman, Rob

AU - Mni, Myriam

AU - Oury, Cecile

AU - Altukhov, Ilya

AU - Alexeev, Dmitry

AU - Aulchenko, Yuri

AU - Amininejad, Leila

AU - Bouma, Gerd

AU - Hoentjen, Frank

AU - Lowenberg, Mark

AU - Oldenburg, Bas

AU - Pierik, Marieke J.

AU - vander Meulen-de Jong, Andrea E.

AU - van der Woude, C. Janneke

AU - Visschedijk, Marijn C.

AU - Lathrop, Mark

AU - Hugot, Jean-Pierre

AU - Weersma, Rinse K.

AU - De Vos, Martine

AU - Franchimont, Denis

AU - Vermeire, Severine

AU - Kubo, Michiaki

AU - Louis, Edouard

AU - Georges, Michel

AU - Abraham, Clara

AU - Achkar, Jean-Paul

AU - Ahmad, Tariq

AU - Ananthakrishnan, Ashwin N.

AU - Andersen, Vibeke

AU - Anderson, Carl A.

AU - Andrews, Jane M.

AU - Annese, Vito

AU - Aumais, Guy

AU - Baidoo, Leonard

AU - Baldassano, Robert N.

AU - Bampton, Peter A.

AU - Brand, Stephan

AU - De Jong, Dirk

AU - Zhang, Hu

PY - 2018/6/21

Y1 - 2018/6/21

KW - INFLAMMATORY-BOWEL-DISEASE

KW - GENOME-WIDE ASSOCIATION

KW - QUANTITATIVE TRAIT LOCUS

KW - RARE VARIANTS

KW - LOW-FREQUENCY

KW - CODING VARIANTS

KW - SEQUENCING DATA

KW - CROHNS-DISEASE

KW - COMPLEX TRAITS

KW - SUSCEPTIBILITY

KW - Humans

KW - Middle Aged

KW - Male

KW - Gene Expression Profiling

KW - Multifactorial Inheritance

KW - Aged, 80 and over

KW - Adult

KW - Female

KW - Crohn Disease/genetics

KW - Genetic Predisposition to Disease

KW - Genetic Association Studies

KW - Genotype

KW - Sequence Analysis, DNA

KW - Aged

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

KW - Cohort Studies

KW - Inflammatory Bowel Diseases/genetics

U2 - 10.1038/s41467-018-04365-8

DO - 10.1038/s41467-018-04365-8

M3 - Article

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 2427

ER -