Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

Keyphrases

• Hypoxia 100%
• LAMP2 100%
• Breast Cancer Cells 100%
• Unfolded Protein Response 100%
• PKR-like ER Kinase 100%
• Activating Transcription Factor 4 (ATF4) 100%
• Hypoxic Condition 25%
• Hypoxia-inducible factor-1α (HIF-1α) 25%
• Poor Prognosis 25%
• Cell Migration 25%
• Collagen 12%
• Three-dimensional (3D) 12%
• Knockdown 12%
• Solid Tumors 12%
• Breast Cancer Cell Lines 12%
• Hypoxic Tumors 12%
• Control Cell 12%
• MDA-MB-231 12%
• Tumor Microenvironment 12%
• SiRNA Knockdown 12%
• Tumor Metastasis 12%
• Metastasis Prognosis 12%
• Tumor Cell Migration 12%
• Multicellular Tumor Spheroids 12%
• Breast Cancer Cell Migration 12%
• Metastasis Model 12%
• Gap Closure Assay 12%
• Moderate Hypoxia 12%
• Invasion Assay 12%
• Transwell Assay 12%
• Multicellular Spheroids 12%
• Diminished Capacity 12%
• MDA-MB-231 Cells 12%

INIS

• cancer 100%
• hypoxia 100%
• proteins 100%
• migration 100%
• breasts 100%
• kinases 100%
• transcription factors 100%
• membrane proteins 100%
• tumors 40%
• metastases 30%
• spheroids 20%
• collagen 10%
• control 10%
• correlations 10%
• comparative evaluations 10%
• in vitro 10%
• capacity 10%
• closures 10%
• solids 10%
• tumor cells 10%

Biochemistry, Genetics and Molecular Biology

• Cancer Cell 100%
• Phosphotransferase 100%
• Kinase 100%
• Membrane Protein 100%
• Unfolded Protein Response 100%
• Activating Transcription Factor 4 100%
• Cell Migration 50%
• Hypoxia Inducible Factor 1 25%
• Tumor Spheroid 12%
• Small Interfering RNA 12%
• Multicellular Spheroid 12%