Hypoxia PET Imaging with [18F]-HX4-A Promising Next-Generation Tracer

Research output: Contribution to journal(Systematic) Review article peer-review

17 Citations (Web of Science)

Abstract

Hypoxia-a common feature of the majority of solid tumors-is a negative prognostic factor, as it is associated with invasion, metastasis and therapy resistance. To date, a variety of methods are available for the assessment of tumor hypoxia, including the use of positron emission tomography (PET). A plethora of hypoxia PET tracers, each with its own strengths and limitations, has been developed and successfully validated, thereby providing useful prognostic or predictive information. The current review focusses on [18F]-HX4, a promising next-generation hypoxia PET tracer. After a brief history of its development, we discuss and compare its characteristics with other hypoxia PET tracers and provide an update on its progression into the clinic. Lastly, we address the potential applications of assessing tumor hypoxia using [18F]-HX4, with a focus on improving patient-tailored therapies.

Original languageEnglish
Article number1322
Number of pages16
JournalCancers
Volume12
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • molecular imaging
  • tumor hypoxia
  • positron emission tomography (PET)
  • [18F]-HX4
  • theranostics
  • response assessment
  • POSITRON-EMISSION-TOMOGRAPHY
  • NECK-CANCER-PATIENTS
  • SQUAMOUS-CELL CARCINOMA
  • TUMOR HYPOXIA
  • F-18 FLUOROMISONIDAZOLE
  • RADIATION-DOSIMETRY
  • PROSPECTIVE TRIAL
  • ADVANCED HEAD
  • RADIOTHERAPY
  • LUNG

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