Hypoxia, oxidative stress, and benzo[a]pyrene induced carcionogenesis

M.A.C. Schults

Research output: ThesisDoctoral ThesisInternal

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Abstract

During the course of our lives we are constantly exposed to all kinds of carcinogenic substances such as benzo(a)pyrene. However, not everyone is equally sensitive to these substances and gets cancer as a result of them. This research investigates if certain processes in the human body can be designated as the cause for this difference. These studies have shown that both lack of oxygen as well as a surplus of free oxygen radicals can lead to more damage to the DNA caused by benzo)a)pyrene. On the one hand this appears to be caused by a reduced decomposition of the substance, but on the other hand also by a decreased recovery of the damage induced by benzo(a)pyrene. Eventually, this research can be used to predict who is more susceptible to carcinogenic substances than others and how the tumours that originate from this can be better treated.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • van Schooten, Frederik, Supervisor
  • Godschalk, Roger, Co-Supervisor
  • Chiu, Roland, Co-Supervisor
Award date11 Dec 2012
Place of Publication's Hertogenbosch
Publisher
Print ISBNs978-90-8891-502-4
DOIs
Publication statusPublished - 1 Jan 2012

Keywords

  • cancer sensitivity
  • DNA damage
  • oxidative stress

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