Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Elizabeth Bowler; Sean Porazinski; Simon Uzor; Philippe Thibault; Mathieu Durand; Elvy Lapointe; Kasper M. A. Rouschop; John Hancock; Ian Wilson; Michael Ladomery

doi:10.1186/s12885-018-4227-7

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson, Michael Ladomery^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Article number	355
Number of pages	11
Journal	BMC Cancer
Volume	18
DOIs	https://doi.org/10.1186/s12885-018-4227-7
Publication status	Published - 2 Apr 2018

Keywords

Hypoxia
Alternative splicing
Prostate cancer
Apoptosis
Splice factors
Splice factor kinases
CLK1
CLK3
TG003
BREAST-CANCER
GENE-EXPRESSION
CARCINOMA-CELLS
INHIBITORS
PROTEINS
MULTIPLE
RESISTANCE
APOPTOSIS
BINDING
TARGET

Access to Document

10.1186/s12885-018-4227-7

Cite this

Bowler, E., Porazinski, S., Uzor, S., Thibault, P., Durand, M., Lapointe, E., Rouschop, K. M. A., Hancock, J., Wilson, I., & Ladomery, M. (2018). Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells. BMC Cancer, 18, [355]. https://doi.org/10.1186/s12885-018-4227-7

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title = "Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells",

keywords = "Hypoxia, Alternative splicing, Prostate cancer, Apoptosis, Splice factors, Splice factor kinases, CLK1, CLK3, TG003, BREAST-CANCER, GENE-EXPRESSION, CARCINOMA-CELLS, INHIBITORS, PROTEINS, MULTIPLE, RESISTANCE, APOPTOSIS, BINDING, TARGET",

author = "Elizabeth Bowler and Sean Porazinski and Simon Uzor and Philippe Thibault and Mathieu Durand and Elvy Lapointe and Rouschop, {Kasper M. A.} and John Hancock and Ian Wilson and Michael Ladomery",

year = "2018",

month = apr,

day = "2",

doi = "10.1186/s12885-018-4227-7",

language = "English",

volume = "18",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "BioMed Central Ltd",

}

Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells. / Bowler, Elizabeth; Porazinski, Sean; Uzor, Simon; Thibault, Philippe; Durand, Mathieu; Lapointe, Elvy; Rouschop, Kasper M. A.; Hancock, John; Wilson, Ian; Ladomery, Michael.

In: BMC Cancer, Vol. 18, 355, 02.04.2018.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

AU - Bowler, Elizabeth

AU - Porazinski, Sean

AU - Uzor, Simon

AU - Thibault, Philippe

AU - Durand, Mathieu

AU - Lapointe, Elvy

AU - Rouschop, Kasper M. A.

AU - Hancock, John

AU - Wilson, Ian

AU - Ladomery, Michael

PY - 2018/4/2

Y1 - 2018/4/2

KW - Hypoxia

KW - Alternative splicing

KW - Prostate cancer

KW - Apoptosis

KW - Splice factors

KW - Splice factor kinases

KW - CLK1

KW - CLK3

KW - TG003

KW - BREAST-CANCER

KW - GENE-EXPRESSION

KW - CARCINOMA-CELLS

KW - INHIBITORS

KW - PROTEINS

KW - MULTIPLE

KW - RESISTANCE

KW - APOPTOSIS

KW - BINDING

KW - TARGET

U2 - 10.1186/s12885-018-4227-7

DO - 10.1186/s12885-018-4227-7

M3 - Article

VL - 18

JO - BMC Cancer

JF - BMC Cancer

SN - 1471-2407

M1 - 355

ER -