Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson, Michael Ladomery*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number355
Number of pages11
JournalBMC Cancer
Volume18
DOIs
Publication statusPublished - 2 Apr 2018

Keywords

  • Hypoxia
  • Alternative splicing
  • Prostate cancer
  • Apoptosis
  • Splice factors
  • Splice factor kinases
  • CLK1
  • CLK3
  • TG003
  • BREAST-CANCER
  • GENE-EXPRESSION
  • CARCINOMA-CELLS
  • INHIBITORS
  • PROTEINS
  • MULTIPLE
  • RESISTANCE
  • APOPTOSIS
  • BINDING
  • TARGET

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