Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation

R. Hameleers; A. Blokland; H.W.M. Steinbusch; V. Visser-Vandewalle; Y. Temel

doi:10.1016/j.bbr.2007.07.011

Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation

R. Hameleers, A. Blokland, H.W.M. Steinbusch, V. Visser-Vandewalle, Y. Temel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Intervening with serotonergic neurotransmission can have profound effects on mobility. For instance, the peripheral administration of the 5HT(2A/c) agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), changes the locomotor activity substantially. Locomotor activity is classically linked to the basal ganglia, in which the subthalamic nucleus (STN) plays a pivotal role. In this study, we tested the hypothesis that deep brain stimulation (DBS) of the STN modulates DOI-induced hypomobility. Rats were implanted with stimulating electrodes at the level of the STN and were tested in an open field (OF) task in various conditions (stimulation on/off, in combination with DOI treatment). We found that DOI administration (i.p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism.

Original language	English
Pages (from-to)	65-7
Journal	Behavioural Brain Research
Volume	185 (1)
DOIs	https://doi.org/10.1016/j.bbr.2007.07.011
Publication status	Published - 1 Jan 2007

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10.1016/j.bbr.2007.07.011

Cite this

@article{6db6a6615ee74b90ba72a4a2f7c3b7cc,

title = "Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation",

abstract = "Intervening with serotonergic neurotransmission can have profound effects on mobility. For instance, the peripheral administration of the 5HT(2A/c) agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), changes the locomotor activity substantially. Locomotor activity is classically linked to the basal ganglia, in which the subthalamic nucleus (STN) plays a pivotal role. In this study, we tested the hypothesis that deep brain stimulation (DBS) of the STN modulates DOI-induced hypomobility. Rats were implanted with stimulating electrodes at the level of the STN and were tested in an open field (OF) task in various conditions (stimulation on/off, in combination with DOI treatment). We found that DOI administration (i.p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism. ",

author = "R. Hameleers and A. Blokland and H.W.M. Steinbusch and V. Visser-Vandewalle and Y. Temel",

year = "2007",

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doi = "10.1016/j.bbr.2007.07.011",

language = "English",

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journal = "Behavioural Brain Research",

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TY - JOUR

T1 - Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation

AU - Hameleers, R.

AU - Blokland, A.

AU - Steinbusch, H.W.M.

AU - Visser-Vandewalle, V.

AU - Temel, Y.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Intervening with serotonergic neurotransmission can have profound effects on mobility. For instance, the peripheral administration of the 5HT(2A/c) agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), changes the locomotor activity substantially. Locomotor activity is classically linked to the basal ganglia, in which the subthalamic nucleus (STN) plays a pivotal role. In this study, we tested the hypothesis that deep brain stimulation (DBS) of the STN modulates DOI-induced hypomobility. Rats were implanted with stimulating electrodes at the level of the STN and were tested in an open field (OF) task in various conditions (stimulation on/off, in combination with DOI treatment). We found that DOI administration (i.p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism.

AB - Intervening with serotonergic neurotransmission can have profound effects on mobility. For instance, the peripheral administration of the 5HT(2A/c) agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), changes the locomotor activity substantially. Locomotor activity is classically linked to the basal ganglia, in which the subthalamic nucleus (STN) plays a pivotal role. In this study, we tested the hypothesis that deep brain stimulation (DBS) of the STN modulates DOI-induced hypomobility. Rats were implanted with stimulating electrodes at the level of the STN and were tested in an open field (OF) task in various conditions (stimulation on/off, in combination with DOI treatment). We found that DOI administration (i.p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism.

U2 - 10.1016/j.bbr.2007.07.011

DO - 10.1016/j.bbr.2007.07.011

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SN - 0166-4328

VL - 185 (1)

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EP - 67

JO - Behavioural Brain Research

JF - Behavioural Brain Research

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