Hypertension Is a Conditional Factor for the Development of Cardiac Hypertrophy in Type 2 Diabetic Mice

Marc van Bilsen*, Anneleen Daniels, Olaf Brouwers, Ben J. A. Janssen, Wouter J. A. Derks, Agnieszka E. Brouns, Chantal Munts, Casper G. Schalkwijk, Ger J. van der Vusse, Frans A. van Nieuwenhoven

*Corresponding author for this work

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32 Citations (Web of Science)

Abstract

Background: Type 2 diabetes is frequently associated with co-morbidities, including hypertension. Here we investigated if hypertension is a critical factor in myocardial remodeling and the development of cardiac dysfunction in type 2 diabetic db/db mice. Methods: Thereto, 14-wks-old male db/db mice and non-diabetic db/+ mice received vehicle or angiotensin II (AngII) for 4 wks to induce mild hypertension (n = 9-10 per group). Left ventricular (LV) function was assessed by serial echocardiography and during a dobutamine stress test. LV tissue was subjected to molecular and (immuno) histochemical analysis to assess effects on hypertrophy, fibrosis and inflammation. Results: Vehicle-treated diabetic mice neither displayed marked myocardial structural remodeling nor cardiac dysfunction. AngII-treatment did not affect body weight and fasting glucose levels, and induced a comparable increase in blood pressure in diabetic and control mice. Nonetheless, AngII-induced LV hypertrophy was significantly more pronounced in diabetic than in control mice as assessed by LV mass (increase +51% and +34%, respectively, p
Original languageEnglish
Article numbere85078
JournalPLOS ONE
Volume9
Issue number1
DOIs
Publication statusPublished - 9 Jan 2014

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