Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

R. Rozenberg, R.T. Mankowski, L.J. van Loon, J.G. Langendonk, E.J. Sijbrands, A.H. van den Meiracker, H.J. Stam, S.F. Praet

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Abstract

OBJECTIVE: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). METHODS: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. RESULTS: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +/- 1.2 (0 L min(-1)); 18.5 +/- 1.5 (5 L min(-1)); 21.7 +/- 1.7 (10 L min(-1)); 24.0 +/- 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. CONCLUSIONS: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.
Original languageEnglish
Article number1
Number of pages8
JournalEuropean Journal of Medical Research
Volume21
DOIs
Publication statusPublished - 8 Jan 2016

Keywords

  • Diabetes type 2
  • Hyperoxia
  • Exercise
  • Oxygen
  • Dose
  • OBSTRUCTIVE PULMONARY-DISEASE
  • SUPPLEMENTAL OXYGEN
  • ENDOTHELIAL DYSFUNCTION
  • INSULIN-RESISTANCE
  • GLYCEMIC CONTROL
  • LUNG-FUNCTION
  • BLOOD-FLOW
  • O-2 UPTAKE
  • HEART-RATE
  • MELLITUS

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