Abstract
OBJECTIVE: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). METHODS: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. RESULTS: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +/- 1.2 (0 L min(-1)); 18.5 +/- 1.5 (5 L min(-1)); 21.7 +/- 1.7 (10 L min(-1)); 24.0 +/- 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. CONCLUSIONS: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.
Original language | English |
---|---|
Article number | 1 |
Number of pages | 8 |
Journal | European Journal of Medical Research |
Volume | 21 |
Issue number | 1 |
DOIs | |
Publication status | Published - 8 Jan 2016 |
Keywords
- Diabetes type 2
- Hyperoxia
- Exercise
- Oxygen
- Dose
- OBSTRUCTIVE PULMONARY-DISEASE
- SUPPLEMENTAL OXYGEN
- ENDOTHELIAL DYSFUNCTION
- INSULIN-RESISTANCE
- GLYCEMIC CONTROL
- LUNG-FUNCTION
- BLOOD-FLOW
- O-2 UPTAKE
- HEART-RATE
- MELLITUS