Hyperoxia increases arterial oxygen pressure during exercise in type 2 diabetes patients: a feasibility study

R. Rozenberg, R.T. Mankowski*, L.J. van Loon, J.G. Langendonk, E.J. Sijbrands, A.H. van den Meiracker, H.J. Stam, S.F. Praet

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2). METHODS: Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20 % Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained. RESULTS: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +/- 1.2 (0 L min(-1)); 18.5 +/- 1.5 (5 L min(-1)); 21.7 +/- 1.7 (10 L min(-1)); 24.0 +/- 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air. CONCLUSIONS: An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.
Original languageEnglish
Article number1
Number of pages8
JournalEuropean Journal of Medical Research
Volume21
Issue number1
DOIs
Publication statusPublished - 8 Jan 2016

Keywords

  • Diabetes type 2
  • Hyperoxia
  • Exercise
  • Oxygen
  • Dose
  • OBSTRUCTIVE PULMONARY-DISEASE
  • SUPPLEMENTAL OXYGEN
  • ENDOTHELIAL DYSFUNCTION
  • INSULIN-RESISTANCE
  • GLYCEMIC CONTROL
  • LUNG-FUNCTION
  • BLOOD-FLOW
  • O-2 UPTAKE
  • HEART-RATE
  • MELLITUS

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