Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

Kelly Nijsten; Marjette H Koot; Joke Mj Bais; Carrie Ris-Stalpers; Rik van Eekelen; Henk A Bremer; David P van der Ham; Wieteke M Heidema; Anjoke Huisjes; Gunilla Kleiverda; Hinke Kruizenga; Simone M Kuppens; Judith Oeh van Laar; Josje Langenveld; Flip van der Made; Dimitri Papatsonis; Marie-José Pelinck; Paula J Pernet; Leonie van Rheenen-Flach; Robbert J Rijnders; Hubertina Cj Scheepers; Tatjana Vogelvang; Ben W Mol; Iris J Grooten; Tessa J Roseboom; Rebecca C Painter

doi:10.1017/S0007114522000587

Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

Kelly Nijsten^*, Marjette H Koot, Joke Mj Bais, Carrie Ris-Stalpers, Rik van Eekelen, Henk A Bremer, David P van der Ham, Wieteke M Heidema, Anjoke Huisjes, Gunilla Kleiverda, Hinke Kruizenga, Simone M Kuppens, Judith Oeh van Laar, Josje Langenveld, Flip van der Made, Dimitri Papatsonis, Marie-José Pelinck, Paula J Pernet, Leonie van Rheenen-Flach, Robbert J RijndersHubertina Cj Scheepers, Tatjana Vogelvang, Ben W Mol, Iris J Grooten, Tessa J Roseboom, Rebecca C Painter

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The present study aimed to investigate the association between hyperemesis gravidarum (HG) severity and the effect of early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated in the MOTHER randomized controlled trial (RCT) and observational cohort. The MOTHER RCT showed that early enteral tube feeding in addition to standard care did not affect symptoms or birth outcomes. Among RCT and cohort participants, we assessed how HG severity affected lipid, c-peptide, glucose and free thyroxine cord blood levels. HG severity measures were: severity of vomiting at inclusion and three weeks after inclusion, pregnancy weight gain and 24-hour energy intake at inclusion, readmissions and duration of hospital admissions. Cord blood measures were also compared between RCT participants allocated to enteral tube feeding and those receiving standard care. Between 2013-2016, 215 women were included: 115 RCT and 100 cohort participants. Eighty-one cord blood samples were available. Univariable, not multivariable regression analysis showed that lower maternal weight gain was associated with higher cord blood glucose levels (β:-0.08, 95% CI:-0.16;-0.00). Lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels in multivariable regression analysis (β:-0.01, 95% CI:-0.02;-0.01). No associations were found between other HG severity measures or allocation to enteral tube feeding and cord blood cardiometabolic markers. In conclusion, while lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels, no other HG severity measures were linked with cord blood cardiometabolic markers, nor were these markers affected by enteral tube feeding.

Original language	English
Article number	0007114522000587
Pages (from-to)	2421-2431
Number of pages	11
Journal	British Journal of Nutrition
Volume	128
Issue number	12
Early online date	24 Feb 2022
DOIs	https://doi.org/10.1017/S0007114522000587
Publication status	Published - 28 Dec 2022

Keywords

ADULTS
APOLIPOPROTEIN-B
CHILDHOOD
CVD
Cardiometabolic risk factors
Fetal blood
Fetal nutrition disorders
GLUCOSE-TOLERANCE
Hyperemesis gravidarum
LIPOPROTEIN
NAUSEA
Nutrition
PREGNANCY
PRENATAL EXPOSURE
PROFILE
WEIGHT

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Nijsten, K., Koot, M. H., Bais, J. M., Ris-Stalpers, C., van Eekelen, R., Bremer, H. A., van der Ham, D. P., Heidema, W. M., Huisjes, A., Kleiverda, G., Kruizenga, H., Kuppens, S. M., van Laar, J. O., Langenveld, J., van der Made, F., Papatsonis, D., Pelinck, M.-J., Pernet, P. J., van Rheenen-Flach, L., ... Painter, R. C. (2022). Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood. British Journal of Nutrition, 128(12), 2421-2431. Article 0007114522000587. https://doi.org/10.1017/S0007114522000587

@article{b13eb56ac9404ebd87b6fb5d61c160fb,

title = "Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood",

abstract = "The present study aimed to investigate the association between hyperemesis gravidarum (HG) severity and the effect of early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated in the MOTHER randomized controlled trial (RCT) and observational cohort. The MOTHER RCT showed that early enteral tube feeding in addition to standard care did not affect symptoms or birth outcomes. Among RCT and cohort participants, we assessed how HG severity affected lipid, c-peptide, glucose and free thyroxine cord blood levels. HG severity measures were: severity of vomiting at inclusion and three weeks after inclusion, pregnancy weight gain and 24-hour energy intake at inclusion, readmissions and duration of hospital admissions. Cord blood measures were also compared between RCT participants allocated to enteral tube feeding and those receiving standard care. Between 2013-2016, 215 women were included: 115 RCT and 100 cohort participants. Eighty-one cord blood samples were available. Univariable, not multivariable regression analysis showed that lower maternal weight gain was associated with higher cord blood glucose levels (β:-0.08, 95% CI:-0.16;-0.00). Lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels in multivariable regression analysis (β:-0.01, 95% CI:-0.02;-0.01). No associations were found between other HG severity measures or allocation to enteral tube feeding and cord blood cardiometabolic markers. In conclusion, while lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels, no other HG severity measures were linked with cord blood cardiometabolic markers, nor were these markers affected by enteral tube feeding.",

keywords = "ADULTS, APOLIPOPROTEIN-B, CHILDHOOD, CVD, Cardiometabolic risk factors, Fetal blood, Fetal nutrition disorders, GLUCOSE-TOLERANCE, Hyperemesis gravidarum, LIPOPROTEIN, NAUSEA, Nutrition, PREGNANCY, PRENATAL EXPOSURE, PROFILE, WEIGHT",

author = "Kelly Nijsten and Koot, {Marjette H} and Bais, {Joke Mj} and Carrie Ris-Stalpers and {van Eekelen}, Rik and Bremer, {Henk A} and {van der Ham}, {David P} and Heidema, {Wieteke M} and Anjoke Huisjes and Gunilla Kleiverda and Hinke Kruizenga and Kuppens, {Simone M} and {van Laar}, {Judith Oeh} and Josje Langenveld and {van der Made}, Flip and Dimitri Papatsonis and Marie-Jos{\'e} Pelinck and Pernet, {Paula J} and {van Rheenen-Flach}, Leonie and Rijnders, {Robbert J} and Scheepers, {Hubertina Cj} and Tatjana Vogelvang and Mol, {Ben W} and Grooten, {Iris J} and Roseboom, {Tessa J} and Painter, {Rebecca C}",

note = "Funding Information: We thank all participating women of the MOTHER study and all staff who made this study possible, including staff from the Amsterdam UMC laboratory who helped us analysing frozen stored blood samples (Resources contributor role). The MOTHER study was conducted with support of a research grant from North West Hospital Group, Alkmaar, the Netherlands (grant number 2013T085). The follow-up study analysing maternal and cord blood samples was conducted with support of a research grant from the Amsterdam Reproduction and Development (AR&D) research institute, Amsterdam UMC, the Netherlands (project number 23346). Publisher Copyright: {\textcopyright} The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society.",

year = "2022",

month = dec,

day = "28",

doi = "10.1017/S0007114522000587",

language = "English",

volume = "128",

pages = "2421--2431",

journal = "British Journal of Nutrition",

issn = "0007-1145",

publisher = "Cambridge University Press",

number = "12",

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Nijsten, K, Koot, MH, Bais, JM, Ris-Stalpers, C, van Eekelen, R, Bremer, HA, van der Ham, DP, Heidema, WM, Huisjes, A, Kleiverda, G, Kruizenga, H, Kuppens, SM, van Laar, JO, Langenveld, J, van der Made, F, Papatsonis, D, Pelinck, M-J, Pernet, PJ, van Rheenen-Flach, L, Rijnders, RJ, Scheepers, HC, Vogelvang, T, Mol, BW, Grooten, IJ, Roseboom, TJ & Painter, RC 2022, 'Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood', British Journal of Nutrition, vol. 128, no. 12, 0007114522000587, pp. 2421-2431. https://doi.org/10.1017/S0007114522000587

TY - JOUR

T1 - Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

AU - Nijsten, Kelly

AU - Koot, Marjette H

AU - Bais, Joke Mj

AU - Ris-Stalpers, Carrie

AU - van Eekelen, Rik

AU - Bremer, Henk A

AU - van der Ham, David P

AU - Heidema, Wieteke M

AU - Huisjes, Anjoke

AU - Kleiverda, Gunilla

AU - Kruizenga, Hinke

AU - Kuppens, Simone M

AU - van Laar, Judith Oeh

AU - Langenveld, Josje

AU - van der Made, Flip

AU - Papatsonis, Dimitri

AU - Pelinck, Marie-José

AU - Pernet, Paula J

AU - van Rheenen-Flach, Leonie

AU - Rijnders, Robbert J

AU - Scheepers, Hubertina Cj

AU - Vogelvang, Tatjana

AU - Mol, Ben W

AU - Grooten, Iris J

AU - Roseboom, Tessa J

AU - Painter, Rebecca C

N1 - Funding Information: We thank all participating women of the MOTHER study and all staff who made this study possible, including staff from the Amsterdam UMC laboratory who helped us analysing frozen stored blood samples (Resources contributor role). The MOTHER study was conducted with support of a research grant from North West Hospital Group, Alkmaar, the Netherlands (grant number 2013T085). The follow-up study analysing maternal and cord blood samples was conducted with support of a research grant from the Amsterdam Reproduction and Development (AR&D) research institute, Amsterdam UMC, the Netherlands (project number 23346). Publisher Copyright: © The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society.

PY - 2022/12/28

Y1 - 2022/12/28

N2 - The present study aimed to investigate the association between hyperemesis gravidarum (HG) severity and the effect of early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated in the MOTHER randomized controlled trial (RCT) and observational cohort. The MOTHER RCT showed that early enteral tube feeding in addition to standard care did not affect symptoms or birth outcomes. Among RCT and cohort participants, we assessed how HG severity affected lipid, c-peptide, glucose and free thyroxine cord blood levels. HG severity measures were: severity of vomiting at inclusion and three weeks after inclusion, pregnancy weight gain and 24-hour energy intake at inclusion, readmissions and duration of hospital admissions. Cord blood measures were also compared between RCT participants allocated to enteral tube feeding and those receiving standard care. Between 2013-2016, 215 women were included: 115 RCT and 100 cohort participants. Eighty-one cord blood samples were available. Univariable, not multivariable regression analysis showed that lower maternal weight gain was associated with higher cord blood glucose levels (β:-0.08, 95% CI:-0.16;-0.00). Lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels in multivariable regression analysis (β:-0.01, 95% CI:-0.02;-0.01). No associations were found between other HG severity measures or allocation to enteral tube feeding and cord blood cardiometabolic markers. In conclusion, while lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels, no other HG severity measures were linked with cord blood cardiometabolic markers, nor were these markers affected by enteral tube feeding.

AB - The present study aimed to investigate the association between hyperemesis gravidarum (HG) severity and the effect of early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated in the MOTHER randomized controlled trial (RCT) and observational cohort. The MOTHER RCT showed that early enteral tube feeding in addition to standard care did not affect symptoms or birth outcomes. Among RCT and cohort participants, we assessed how HG severity affected lipid, c-peptide, glucose and free thyroxine cord blood levels. HG severity measures were: severity of vomiting at inclusion and three weeks after inclusion, pregnancy weight gain and 24-hour energy intake at inclusion, readmissions and duration of hospital admissions. Cord blood measures were also compared between RCT participants allocated to enteral tube feeding and those receiving standard care. Between 2013-2016, 215 women were included: 115 RCT and 100 cohort participants. Eighty-one cord blood samples were available. Univariable, not multivariable regression analysis showed that lower maternal weight gain was associated with higher cord blood glucose levels (β:-0.08, 95% CI:-0.16;-0.00). Lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels in multivariable regression analysis (β:-0.01, 95% CI:-0.02;-0.01). No associations were found between other HG severity measures or allocation to enteral tube feeding and cord blood cardiometabolic markers. In conclusion, while lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels, no other HG severity measures were linked with cord blood cardiometabolic markers, nor were these markers affected by enteral tube feeding.

KW - ADULTS

KW - APOLIPOPROTEIN-B

KW - CHILDHOOD

KW - CVD

KW - Cardiometabolic risk factors

KW - Fetal blood

KW - Fetal nutrition disorders

KW - GLUCOSE-TOLERANCE

KW - Hyperemesis gravidarum

KW - LIPOPROTEIN

KW - NAUSEA

KW - Nutrition

KW - PREGNANCY

KW - PRENATAL EXPOSURE

KW - PROFILE

KW - WEIGHT

U2 - 10.1017/S0007114522000587

DO - 10.1017/S0007114522000587

M3 - Article

C2 - 35197140

SN - 0007-1145

VL - 128

SP - 2421

EP - 2431

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 12

M1 - 0007114522000587

ER -

Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood

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