Hyperdopaminergic Status in Experimental Huntington Disease

Ali Jahanshahi, Rinske Vlamings, Ahmet Hilmi Kaya, Lee Wei Lim, Marcus L. F. Janssen, Sonny Tan, Veerle Visser-Vandewalle, Harry W. M. Steinbusch, Yasin Temel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Huntington disease has been linked to increased dopaminergic neurotransmission in the striatum, and clinical studies have demonstrated that the associated chorea can be treated with dopamine antagonist or dopamine-depleting drugs. The origin of this hyper-dopaminergic status is unknown. Because substantia nigra pars compacta and the ventral tegmental area are the main sources of striatal dopamine input, we hypothesized that changes in these regions relate to striatal dopaminergic alterations. Here, in a recently generated transgenic rat Huntington disease model that shows progressive striatal neurodegeneration and chorea, we found evidence of increased dopamine levels in the striatum. We also demonstrate more dopaminergic cells in the substantia nigra pars compacta and ventral tegmental area in these rats. These results suggest that increased striatal dopamine comes from these 2 main nuclei, and that it is not necessarily related to shrinkage of the striatum. The findings implicate increased dopamine input from these nuclei in the pathogenesis of chorea in Huntington disease.
Original languageEnglish
Pages (from-to)910-917
JournalJournal of Neuropathology and Experimental Neurology
Volume69
Issue number9
DOIs
Publication statusPublished - Sept 2010

Keywords

  • Chorea
  • Dopamine
  • Huntington disease
  • Striatum
  • Substantia nigra pars compacta
  • Tyrosine hydroxylase
  • Ventral tegmental area

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