Hybrid total-body pet scanners-current status and future perspectives

V. Nadig; K. Herrmann; F.M. Mottaghy; V. Schulz

doi:10.1007/s00259-021-05536-4

Hybrid total-body pet scanners-current status and future perspectives

V. Nadig, K. Herrmann, F.M. Mottaghy, V. Schulz^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Purpose Since the 1990s, PET has been successfully combined with MR or CT systems. In the past years, especially PET systems have seen a trend towards an enlarged axial field of view (FOV), up to a factor of ten. Methods Conducting a thorough literature research, we summarize the status quo of contemporary total-body (TB) PET/CT scanners and give an outlook on possible future developments. Results Currently, three human TB PET/CT systems have been developed: The PennPET Explorer, the uExplorer, and the Biograph Vision Quadra realize aFOVs between 1 and 2 m and show a tremendous increase in system sensitivity related to their longer gantries. Conclusion The increased system sensitivity paves the way for short-term, low-dose, and dynamic TB imaging as well as new examination methods in almost all areas of imaging.

Original language	English
Pages (from-to)	445-459
Number of pages	15
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	49
Issue number	2
Early online date	14 Oct 2021
DOIs	https://doi.org/10.1007/s00259-021-05536-4
Publication status	Published - Jan 2022

Keywords

PET
CT
MRI
Total-body
Sensitivity
Long axial FOV
MONOLITHIC SCINTILLATOR CRYSTALS
HIGH QUANTUM EFFICIENCY
PERFORMANCE EVALUATION
SILICON PHOTOMULTIPLIERS
PHOTO-DETECTORS
SYSTEM
PET/MRI
SIPM
ALGORITHMS
READOUT

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10.1007/s00259-021-05536-4Licence: CC BY

Cite this

@article{65d04464fa3747b4ab5e894d620b9274,

title = "Hybrid total-body pet scanners-current status and future perspectives",

abstract = "Purpose Since the 1990s, PET has been successfully combined with MR or CT systems. In the past years, especially PET systems have seen a trend towards an enlarged axial field of view (FOV), up to a factor of ten. Methods Conducting a thorough literature research, we summarize the status quo of contemporary total-body (TB) PET/CT scanners and give an outlook on possible future developments. Results Currently, three human TB PET/CT systems have been developed: The PennPET Explorer, the uExplorer, and the Biograph Vision Quadra realize aFOVs between 1 and 2 m and show a tremendous increase in system sensitivity related to their longer gantries. Conclusion The increased system sensitivity paves the way for short-term, low-dose, and dynamic TB imaging as well as new examination methods in almost all areas of imaging.",

keywords = "PET, CT, MRI, Total-body, Sensitivity, Long axial FOV, MONOLITHIC SCINTILLATOR CRYSTALS, HIGH QUANTUM EFFICIENCY, PERFORMANCE EVALUATION, SILICON PHOTOMULTIPLIERS, PHOTO-DETECTORS, SYSTEM, PET/MRI, SIPM, ALGORITHMS, READOUT",

author = "V. Nadig and K. Herrmann and F.M. Mottaghy and V. Schulz",

note = "Funding Information: K.H. reports personal fees from Bayer, personal fees and other from Sofie Biosciences, personal fees from SIRTEX, non-financial support from ABX, personal fees from Adacap, personal fees from Curium, personal fees from Endocyte, grants and personal fees from BTG, personal fees from IPSEN, personal fees from Siemens Healthineers, personal fees from GE Healthcare, personal fees from Amgen, personal fees from Novartis, personal fees from ymabs, personal fees from Bain Capital, personal fees from MPM Capital, outside the submitted work. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2022",

month = jan,

doi = "10.1007/s00259-021-05536-4",

language = "English",

volume = "49",

pages = "445--459",

journal = "European Journal of Nuclear Medicine and Molecular Imaging",

issn = "1619-7070",

publisher = "Springer, Cham",

number = "2",

}

TY - JOUR

T1 - Hybrid total-body pet scanners-current status and future perspectives

AU - Nadig, V.

AU - Herrmann, K.

AU - Mottaghy, F.M.

AU - Schulz, V.

N1 - Funding Information: K.H. reports personal fees from Bayer, personal fees and other from Sofie Biosciences, personal fees from SIRTEX, non-financial support from ABX, personal fees from Adacap, personal fees from Curium, personal fees from Endocyte, grants and personal fees from BTG, personal fees from IPSEN, personal fees from Siemens Healthineers, personal fees from GE Healthcare, personal fees from Amgen, personal fees from Novartis, personal fees from ymabs, personal fees from Bain Capital, personal fees from MPM Capital, outside the submitted work. Publisher Copyright: © 2021, The Author(s).

PY - 2022/1

Y1 - 2022/1

N2 - Purpose Since the 1990s, PET has been successfully combined with MR or CT systems. In the past years, especially PET systems have seen a trend towards an enlarged axial field of view (FOV), up to a factor of ten. Methods Conducting a thorough literature research, we summarize the status quo of contemporary total-body (TB) PET/CT scanners and give an outlook on possible future developments. Results Currently, three human TB PET/CT systems have been developed: The PennPET Explorer, the uExplorer, and the Biograph Vision Quadra realize aFOVs between 1 and 2 m and show a tremendous increase in system sensitivity related to their longer gantries. Conclusion The increased system sensitivity paves the way for short-term, low-dose, and dynamic TB imaging as well as new examination methods in almost all areas of imaging.

AB - Purpose Since the 1990s, PET has been successfully combined with MR or CT systems. In the past years, especially PET systems have seen a trend towards an enlarged axial field of view (FOV), up to a factor of ten. Methods Conducting a thorough literature research, we summarize the status quo of contemporary total-body (TB) PET/CT scanners and give an outlook on possible future developments. Results Currently, three human TB PET/CT systems have been developed: The PennPET Explorer, the uExplorer, and the Biograph Vision Quadra realize aFOVs between 1 and 2 m and show a tremendous increase in system sensitivity related to their longer gantries. Conclusion The increased system sensitivity paves the way for short-term, low-dose, and dynamic TB imaging as well as new examination methods in almost all areas of imaging.

KW - PET

KW - CT

KW - MRI

KW - Total-body

KW - Sensitivity

KW - Long axial FOV

KW - MONOLITHIC SCINTILLATOR CRYSTALS

KW - HIGH QUANTUM EFFICIENCY

KW - PERFORMANCE EVALUATION

KW - SILICON PHOTOMULTIPLIERS

KW - PHOTO-DETECTORS

KW - SYSTEM

KW - PET/MRI

KW - SIPM

KW - ALGORITHMS

KW - READOUT

U2 - 10.1007/s00259-021-05536-4

DO - 10.1007/s00259-021-05536-4

M3 - (Systematic) Review article

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JO - European Journal of Nuclear Medicine and Molecular Imaging

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