TY - JOUR
T1 - Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
AU - Geis, Christian
AU - Gruenewald, Benedikt
AU - Weishaupt, Andreas
AU - Wultsch, Thomas
AU - Toyka, Klaus V.
AU - Reif, Andreas
AU - Sommer, Claudia
PY - 2012/8
Y1 - 2012/8
N2 - Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.
AB - Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.
KW - Anti-amphiphysin antibodies
KW - Anxiety
KW - Stiff person syndrome
KW - Amygdala
KW - Passive transfer
U2 - 10.1007/s00702-012-0773-3
DO - 10.1007/s00702-012-0773-3
M3 - Article
C2 - 22331304
SN - 0300-9564
VL - 119
SP - 981
EP - 985
JO - Journal of Neural Transmission
JF - Journal of Neural Transmission
IS - 8
ER -