Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer

Christian Geis*, Benedikt Gruenewald, Andreas Weishaupt, Thomas Wultsch, Klaus V. Toyka, Andreas Reif, Claudia Sommer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

26 Citations (Web of Science)


Stiff person syndrome with auto-antibodies against amphiphysin is characterized by muscular stiffness, spasms, and anxiety which is a less appreciated core symptom. Here, we report that intrathecal application of purified immunoglobulin G-antibodies against amphiphysin from one patient induce anxiety behavior in rats. Immunostaining demonstrated binding of anti-amphiphysin antibodies to brain structures which are associated with anxiety disorders, such as the amygdala. We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways.
Original languageEnglish
Pages (from-to)981-985
JournalJournal of Neural Transmission
Issue number8
Publication statusPublished - Aug 2012


  • Anti-amphiphysin antibodies
  • Anxiety
  • Stiff person syndrome
  • Amygdala
  • Passive transfer

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