Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

Lea Maitre; Jeroen de Bont; Maribel Casas; Oliver Robinson; Gunn Marit Aasvang; Lydiane Agier; Sandra Andrusaityte; Ferran Ballester; Xavier Basagana; Eva Borras; Celine Brochot; Mariona Bustamante; Angel Carracedo; Montserrat de Castro; Audrius Dedele; David Donaire-Gonzalez; Xavier Estivill; Jorunn Evandt; Serena Fossati; Lise Giorgis-Allemand; Juan R. Gonzalez; Berit Granum; Regina Grazuleviciene; Kristine Bjerve Gutzkow; Line Smastuen Haug; Carles Hernandez-Ferrer; Barbara Heude; Jesus Ibarluzea; Jordi Julvez; Marianna Karachaliou; Hector C. Keun; Norun Hjertager Krog; Chung-Ho E. Lau; Vasiliki Leventakou; Sarah Lyon-Caen; Cyntia Manzano; Dan Mason; Rosemary McEachan; Helle Margrete Meltzer; Inga Petraviciene; Joane Quentin; Theano Roumeliotaki; Eduard Sabido; Pierre-Jean Saulnier; Alexandros P. Siskos; Valerie Siroux; Jordi Sunyer; Ibon Tamayo; Jose Urquiza; Marina Vafeiadi; Diana van Gent; Marta Vives-Usano; Dagmar Waiblinger; Charline Warembourg; Leda Chatzi; Muireann Coen; Peter van den Hazel; Mark J. Nieuwenhuijsen; Remy Slama; Cathrine Thomsen; John Wright; Martine Vrijheid

doi:10.1136/bmjopen-2017-021311

Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

Lea Maitre, Jeroen de Bont, Maribel Casas, Oliver Robinson, Gunn Marit Aasvang, Lydiane Agier, Sandra Andrusaityte, Ferran Ballester, Xavier Basagana, Eva Borras, Celine Brochot, Mariona Bustamante, Angel Carracedo, Montserrat de Castro, Audrius Dedele, David Donaire-Gonzalez, Xavier Estivill, Jorunn Evandt, Serena Fossati, Lise Giorgis-AllemandJuan R. Gonzalez, Berit Granum, Regina Grazuleviciene, Kristine Bjerve Gutzkow, Line Smastuen Haug, Carles Hernandez-Ferrer, Barbara Heude, Jesus Ibarluzea, Jordi Julvez, Marianna Karachaliou, Hector C. Keun, Norun Hjertager Krog, Chung-Ho E. Lau, Vasiliki Leventakou, Sarah Lyon-Caen, Cyntia Manzano, Dan Mason, Rosemary McEachan, Helle Margrete Meltzer, Inga Petraviciene, Joane Quentin, Theano Roumeliotaki, Eduard Sabido, Pierre-Jean Saulnier, Alexandros P. Siskos, Valerie Siroux, Jordi Sunyer, Ibon Tamayo, Jose Urquiza, Marina Vafeiadi, Diana van Gent, Marta Vives-Usano, Dagmar Waiblinger, Charline Warembourg, Leda Chatzi, Muireann Coen, Peter van den Hazel, Mark J. Nieuwenhuijsen, Remy Slama, Cathrine Thomsen, John Wright, Martine Vrijheid^*

^*Corresponding author for this work

NUTRIM - Healthy Ageing

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project.

Original language	English
Article number	021311
Number of pages	17
Journal	BMJ Open
Volume	8
Issue number	9
DOIs	https://doi.org/10.1136/bmjopen-2017-021311
Publication status	Published - 1 Sept 2018

Keywords

birth cohort
exposome
epidemiology
omics
public health
community child health
USE REGRESSION-MODELS
LAND-USE
AIR-POLLUTION
CHILD COHORT
EXPOSURE
PROFILE
HEALTH
PREGNANCY
MOTHER
AREAS

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Maitre, L., de Bont, J., Casas, M., Robinson, O., Aasvang, G. M., Agier, L., Andrusaityte, S., Ballester, F., Basagana, X., Borras, E., Brochot, C., Bustamante, M., Carracedo, A., de Castro, M., Dedele, A., Donaire-Gonzalez, D., Estivill, X., Evandt, J., Fossati, S., ... Vrijheid, M. (2018). Human Early Life Exposome (HELIX) study: a European population-based exposome cohort . BMJ Open, 8(9), Article 021311. https://doi.org/10.1136/bmjopen-2017-021311

@article{8ade723ea818488ba3b49515ed382b8c,

title = "Human Early Life Exposome (HELIX) study: a European population-based exposome cohort ",

abstract = "Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project.",

keywords = "birth cohort, exposome, epidemiology, omics, public health, community child health, USE REGRESSION-MODELS, LAND-USE, AIR-POLLUTION, CHILD COHORT, EXPOSURE, PROFILE, HEALTH, PREGNANCY, MOTHER, AREAS",

author = "Lea Maitre and {de Bont}, Jeroen and Maribel Casas and Oliver Robinson and Aasvang, {Gunn Marit} and Lydiane Agier and Sandra Andrusaityte and Ferran Ballester and Xavier Basagana and Eva Borras and Celine Brochot and Mariona Bustamante and Angel Carracedo and {de Castro}, Montserrat and Audrius Dedele and David Donaire-Gonzalez and Xavier Estivill and Jorunn Evandt and Serena Fossati and Lise Giorgis-Allemand and Gonzalez, {Juan R.} and Berit Granum and Regina Grazuleviciene and Gutzkow, {Kristine Bjerve} and Haug, {Line Smastuen} and Carles Hernandez-Ferrer and Barbara Heude and Jesus Ibarluzea and Jordi Julvez and Marianna Karachaliou and Keun, {Hector C.} and Krog, {Norun Hjertager} and Lau, {Chung-Ho E.} and Vasiliki Leventakou and Sarah Lyon-Caen and Cyntia Manzano and Dan Mason and Rosemary McEachan and Meltzer, {Helle Margrete} and Inga Petraviciene and Joane Quentin and Theano Roumeliotaki and Eduard Sabido and Pierre-Jean Saulnier and Siskos, {Alexandros P.} and Valerie Siroux and Jordi Sunyer and Ibon Tamayo and Jose Urquiza and Marina Vafeiadi and {van Gent}, Diana and Marta Vives-Usano and Dagmar Waiblinger and Charline Warembourg and Leda Chatzi and Muireann Coen and {van den Hazel}, Peter and Nieuwenhuijsen, {Mark J.} and Remy Slama and Cathrine Thomsen and John Wright and Martine Vrijheid",

year = "2018",

month = sep,

day = "1",

doi = "10.1136/bmjopen-2017-021311",

language = "English",

volume = "8",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "9",

}

Maitre, L, de Bont, J, Casas, M, Robinson, O, Aasvang, GM, Agier, L, Andrusaityte, S, Ballester, F, Basagana, X, Borras, E, Brochot, C, Bustamante, M, Carracedo, A, de Castro, M, Dedele, A, Donaire-Gonzalez, D, Estivill, X, Evandt, J, Fossati, S, Giorgis-Allemand, L, Gonzalez, JR, Granum, B, Grazuleviciene, R, Gutzkow, KB, Haug, LS, Hernandez-Ferrer, C, Heude, B, Ibarluzea, J, Julvez, J, Karachaliou, M, Keun, HC, Krog, NH, Lau, C-HE, Leventakou, V, Lyon-Caen, S, Manzano, C, Mason, D, McEachan, R, Meltzer, HM, Petraviciene, I, Quentin, J, Roumeliotaki, T, Sabido, E, Saulnier, P-J, Siskos, AP, Siroux, V, Sunyer, J, Tamayo, I, Urquiza, J, Vafeiadi, M, van Gent, D, Vives-Usano, M, Waiblinger, D, Warembourg, C, Chatzi, L, Coen, M, van den Hazel, P, Nieuwenhuijsen, MJ, Slama, R, Thomsen, C, Wright, J & Vrijheid, M 2018, 'Human Early Life Exposome (HELIX) study: a European population-based exposome cohort ', BMJ Open, vol. 8, no. 9, 021311. https://doi.org/10.1136/bmjopen-2017-021311

TY - JOUR

T1 - Human Early Life Exposome (HELIX) study

T2 - a European population-based exposome cohort

AU - Maitre, Lea

AU - de Bont, Jeroen

AU - Casas, Maribel

AU - Robinson, Oliver

AU - Aasvang, Gunn Marit

AU - Agier, Lydiane

AU - Andrusaityte, Sandra

AU - Ballester, Ferran

AU - Basagana, Xavier

AU - Borras, Eva

AU - Brochot, Celine

AU - Bustamante, Mariona

AU - Carracedo, Angel

AU - de Castro, Montserrat

AU - Dedele, Audrius

AU - Donaire-Gonzalez, David

AU - Estivill, Xavier

AU - Evandt, Jorunn

AU - Fossati, Serena

AU - Giorgis-Allemand, Lise

AU - Gonzalez, Juan R.

AU - Granum, Berit

AU - Grazuleviciene, Regina

AU - Gutzkow, Kristine Bjerve

AU - Haug, Line Smastuen

AU - Hernandez-Ferrer, Carles

AU - Heude, Barbara

AU - Ibarluzea, Jesus

AU - Julvez, Jordi

AU - Karachaliou, Marianna

AU - Keun, Hector C.

AU - Krog, Norun Hjertager

AU - Lau, Chung-Ho E.

AU - Leventakou, Vasiliki

AU - Lyon-Caen, Sarah

AU - Manzano, Cyntia

AU - Mason, Dan

AU - McEachan, Rosemary

AU - Meltzer, Helle Margrete

AU - Petraviciene, Inga

AU - Quentin, Joane

AU - Roumeliotaki, Theano

AU - Sabido, Eduard

AU - Saulnier, Pierre-Jean

AU - Siskos, Alexandros P.

AU - Siroux, Valerie

AU - Sunyer, Jordi

AU - Tamayo, Ibon

AU - Urquiza, Jose

AU - Vafeiadi, Marina

AU - van Gent, Diana

AU - Vives-Usano, Marta

AU - Waiblinger, Dagmar

AU - Warembourg, Charline

AU - Chatzi, Leda

AU - Coen, Muireann

AU - van den Hazel, Peter

AU - Nieuwenhuijsen, Mark J.

AU - Slama, Remy

AU - Thomsen, Cathrine

AU - Wright, John

AU - Vrijheid, Martine

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project.

AB - Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project.

KW - birth cohort

KW - exposome

KW - epidemiology

KW - omics

KW - public health

KW - community child health

KW - USE REGRESSION-MODELS

KW - LAND-USE

KW - AIR-POLLUTION

KW - CHILD COHORT

KW - EXPOSURE

KW - PROFILE

KW - HEALTH

KW - PREGNANCY

KW - MOTHER

KW - AREAS

U2 - 10.1136/bmjopen-2017-021311

DO - 10.1136/bmjopen-2017-021311

M3 - Article

C2 - 30206078

SN - 2044-6055

VL - 8

JO - BMJ Open

JF - BMJ Open

IS - 9

M1 - 021311

ER -

Human Early Life Exposome (HELIX) study: a European population-based exposome cohort

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Keywords

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