TY - JOUR
T1 - Human brown adipose tissue
T2 - Underestimated target in metabolic disease?
AU - Moonen, Michiel P. B.
AU - Nascimento, Emmani B. M.
AU - van Marken Lichtenbelt, Wouter D.
N1 - Funding Information:
We acknowledge the support of the Dutch Heart Foundation (CVON2014-02 ENERGISE) and the European Foundation for the study of Diabetes (EFSD).
Funding Information:
We acknowledge the support of the Dutch Heart Foundation ( CVON2014-02 ENERGISE ) and the European Foundation for the study of Diabetes (EFSD).
Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2019/1
Y1 - 2019/1
N2 - Active brown adipose tissue (BAT) has, since it rediscovery in adult humans in 2009, received much attention for its ability to increase energy expenditure when activated. By means of mitochondrial uncoupling activity BAT'S main function is to produce heat instead of storing energy such as in white adipose tissue (WAT). Therefore, BAT is considered a new potential target to treat obesity and the metabolic syndrome. However, the contribution of this thermogenic tissue is still a matter of debate among researchers.The aim of this review is to give an overview of the differences between classical brown adipocytes and inducible beige adipocytes in humans, and the potential activators of BAT in humans. Furthermore newly described genetic markers for identification of these two types of brown adipocytes are examined. Finally, the potential of the current measurement techniques, and the contribution of BAT activity to whole body energy expenditure are discussed.
AB - Active brown adipose tissue (BAT) has, since it rediscovery in adult humans in 2009, received much attention for its ability to increase energy expenditure when activated. By means of mitochondrial uncoupling activity BAT'S main function is to produce heat instead of storing energy such as in white adipose tissue (WAT). Therefore, BAT is considered a new potential target to treat obesity and the metabolic syndrome. However, the contribution of this thermogenic tissue is still a matter of debate among researchers.The aim of this review is to give an overview of the differences between classical brown adipocytes and inducible beige adipocytes in humans, and the potential activators of BAT in humans. Furthermore newly described genetic markers for identification of these two types of brown adipocytes are examined. Finally, the potential of the current measurement techniques, and the contribution of BAT activity to whole body energy expenditure are discussed.
KW - Brown adipose tissue
KW - Energy metabolism
KW - POSITRON-EMISSION-TOMOGRAPHY
KW - ENERGY-EXPENDITURE
KW - GENE-EXPRESSION
KW - FUNCTIONAL-CHARACTERIZATION
KW - NONSHIVERING THERMOGENESIS
KW - SUPRACLAVICULAR REGION
KW - ADRENERGIC-STIMULATION
KW - OXIDATIVE-METABOLISM
KW - BEIGE ADIPOCYTES
KW - COLD-EXPOSURE
U2 - 10.1016/j.bbalip.2018.05.012
DO - 10.1016/j.bbalip.2018.05.012
M3 - (Systematic) Review article
C2 - 29802972
SN - 1388-1981
VL - 1864
SP - 104
EP - 112
JO - Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
IS - 1
ER -