Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

J. Jiang*, S. Messner, J. M. Kelm, M. van Herwijnen, D. G. J. Jennen, J. C. Kleinjans, T. M. de Kok

*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original languageEnglish
Pages (from-to)34-44
Number of pages11
JournalToxicology Letters
Volume312
DOIs
Publication statusPublished - 15 Sep 2019

Keywords

  • Human Kupffer cells
  • Human primary hepatocytes
  • 3D co-culture
  • Hepatotoxicity
  • Transcriptomics
  • Acetaminophen-inflammation interaction
  • KUPFFER CELLS
  • ACETAMINOPHEN
  • INTERLEUKIN-8
  • RECEPTOR
  • PHAGOCYTOSIS
  • HEPATOCYTES
  • ACTIVATION
  • EXPRESSION
  • MUTATIONS
  • COCULTURE

Cite this

Jiang, J. ; Messner, S. ; Kelm, J. M. ; van Herwijnen, M. ; Jennen, D. G. J. ; Kleinjans, J. C. ; de Kok, T. M. / Human 3D multicellular microtissues : An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. In: Toxicology Letters. 2019 ; Vol. 312. pp. 34-44.
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title = "Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity",
keywords = "Human Kupffer cells, Human primary hepatocytes, 3D co-culture, Hepatotoxicity, Transcriptomics, Acetaminophen-inflammation interaction, KUPFFER CELLS, ACETAMINOPHEN, INTERLEUKIN-8, RECEPTOR, PHAGOCYTOSIS, HEPATOCYTES, ACTIVATION, EXPRESSION, MUTATIONS, COCULTURE",
author = "J. Jiang and S. Messner and Kelm, {J. M.} and {van Herwijnen}, M. and Jennen, {D. G. J.} and Kleinjans, {J. C.} and {de Kok}, {T. M.}",
year = "2019",
month = "9",
day = "15",
doi = "10.1016/j.toxlet.2019.05.004",
language = "English",
volume = "312",
pages = "34--44",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier Ireland Ltd",

}

Jiang, J, Messner, S, Kelm, JM, van Herwijnen, M, Jennen, DGJ, Kleinjans, JC & de Kok, TM 2019, 'Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity', Toxicology Letters, vol. 312, pp. 34-44. https://doi.org/10.1016/j.toxlet.2019.05.004

Human 3D multicellular microtissues : An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. / Jiang, J.; Messner, S.; Kelm, J. M.; van Herwijnen, M.; Jennen, D. G. J.; Kleinjans, J. C.; de Kok, T. M.

In: Toxicology Letters, Vol. 312, 15.09.2019, p. 34-44.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Human 3D multicellular microtissues

T2 - An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

AU - Jiang, J.

AU - Messner, S.

AU - Kelm, J. M.

AU - van Herwijnen, M.

AU - Jennen, D. G. J.

AU - Kleinjans, J. C.

AU - de Kok, T. M.

PY - 2019/9/15

Y1 - 2019/9/15

KW - Human Kupffer cells

KW - Human primary hepatocytes

KW - 3D co-culture

KW - Hepatotoxicity

KW - Transcriptomics

KW - Acetaminophen-inflammation interaction

KW - KUPFFER CELLS

KW - ACETAMINOPHEN

KW - INTERLEUKIN-8

KW - RECEPTOR

KW - PHAGOCYTOSIS

KW - HEPATOCYTES

KW - ACTIVATION

KW - EXPRESSION

KW - MUTATIONS

KW - COCULTURE

U2 - 10.1016/j.toxlet.2019.05.004

DO - 10.1016/j.toxlet.2019.05.004

M3 - Article

VL - 312

SP - 34

EP - 44

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

ER -

Jiang J, Messner S, Kelm JM, van Herwijnen M, Jennen DGJ, Kleinjans JC et al. Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicology Letters. 2019 Sep 15;312:34-44. https://doi.org/10.1016/j.toxlet.2019.05.004

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