Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

J. Jiang*, S. Messner, J. M. Kelm, M. van Herwijnen, D. G. J. Jennen, J. C. Kleinjans, T. M. de Kok

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)34-44
Number of pages11
JournalToxicology Letters
Volume312
DOIs
Publication statusPublished - 15 Sep 2019

Keywords

  • Human Kupffer cells
  • Human primary hepatocytes
  • 3D co-culture
  • Hepatotoxicity
  • Transcriptomics
  • Acetaminophen-inflammation interaction
  • KUPFFER CELLS
  • ACETAMINOPHEN
  • INTERLEUKIN-8
  • RECEPTOR
  • PHAGOCYTOSIS
  • HEPATOCYTES
  • ACTIVATION
  • EXPRESSION
  • MUTATIONS
  • COCULTURE

Cite this