Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

J. Jiang; S. Messner; J. M. Kelm; M. van Herwijnen; D. G. J. Jennen; J. C. Kleinjans; T. M. de Kok

doi:10.1016/j.toxlet.2019.05.004

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

J. Jiang^*, S. Messner, J. M. Kelm, M. van Herwijnen, D. G. J. Jennen, J. C. Kleinjans, T. M. de Kok

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	34-44
Number of pages	11
Journal	Toxicology Letters
Volume	312
DOIs	https://doi.org/10.1016/j.toxlet.2019.05.004
Publication status	Published - 15 Sep 2019

Keywords

Human Kupffer cells
Human primary hepatocytes
3D co-culture
Hepatotoxicity
Transcriptomics
Acetaminophen-inflammation interaction
KUPFFER CELLS
ACETAMINOPHEN
INTERLEUKIN-8
RECEPTOR
PHAGOCYTOSIS
HEPATOCYTES
ACTIVATION
EXPRESSION
MUTATIONS
COCULTURE

Cite this

Jiang, J., Messner, S., Kelm, J. M., van Herwijnen, M., Jennen, D. G. J., Kleinjans, J. C., & de Kok, T. M. (2019). Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicology Letters, 312, 34-44. https://doi.org/10.1016/j.toxlet.2019.05.004

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title = "Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity",

keywords = "Human Kupffer cells, Human primary hepatocytes, 3D co-culture, Hepatotoxicity, Transcriptomics, Acetaminophen-inflammation interaction, KUPFFER CELLS, ACETAMINOPHEN, INTERLEUKIN-8, RECEPTOR, PHAGOCYTOSIS, HEPATOCYTES, ACTIVATION, EXPRESSION, MUTATIONS, COCULTURE",

author = "J. Jiang and S. Messner and Kelm, {J. M.} and {van Herwijnen}, M. and Jennen, {D. G. J.} and Kleinjans, {J. C.} and {de Kok}, {T. M.}",

year = "2019",

month = sep

day = "15",

doi = "10.1016/j.toxlet.2019.05.004",

language = "English",

volume = "312",

pages = "34--44",

journal = "Toxicology Letters",

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Human 3D multicellular microtissues : An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. / Jiang, J.; Messner, S.; Kelm, J. M.; van Herwijnen, M.; Jennen, D. G. J.; Kleinjans, J. C.; de Kok, T. M.

In: Toxicology Letters, Vol. 312, 15.09.2019, p. 34-44.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Human 3D multicellular microtissues

T2 - An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity

AU - Jiang, J.

AU - Messner, S.

AU - Kelm, J. M.

AU - van Herwijnen, M.

AU - Jennen, D. G. J.

AU - Kleinjans, J. C.

AU - de Kok, T. M.

PY - 2019/9/15

Y1 - 2019/9/15

KW - Human Kupffer cells

KW - Human primary hepatocytes

KW - 3D co-culture

KW - Hepatotoxicity

KW - Transcriptomics

KW - Acetaminophen-inflammation interaction

KW - KUPFFER CELLS

KW - ACETAMINOPHEN

KW - INTERLEUKIN-8

KW - RECEPTOR

KW - PHAGOCYTOSIS

KW - HEPATOCYTES

KW - ACTIVATION

KW - EXPRESSION

KW - MUTATIONS

KW - COCULTURE

U2 - 10.1016/j.toxlet.2019.05.004

DO - 10.1016/j.toxlet.2019.05.004

M3 - Article

VL - 312

SP - 34

EP - 44

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

ER -

Access to Document

10.1016/j.toxlet.2019.05.004