How Do Dual Long-Acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease?

Kai M. Beeh*, Pierre-Regis Burgel, Frits M. E. Franssen, Jose Luis Lopez-Campos, Stelios Loukides, John R. Hurst, Matjaz Flezar, Charlotte Suppli Ulrik, Fabiano Di Marco, Daiana Stolz, Arschang Valipour, Brian Casserly, Bjorn Stallberg, Konstantinos Kostikas, Jadwiga A. Wedzicha

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Original languageEnglish
Pages (from-to)139-149
Number of pages11
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume196
Issue number2
DOIs
Publication statusPublished - 15 Jul 2017

Keywords

  • hyperinflation
  • inflammation
  • inhaled corticosteroid
  • mucus
  • RANDOMIZED CONTROLLED-TRIALS
  • LUNG-VOLUME REDUCTION
  • COPD EXACERBATIONS
  • TIOTROPIUM BROMIDE
  • MUCUS HYPERSECRETION
  • EPITHELIAL-CELLS
  • DOUBLE-BLIND
  • SALMETEROL/FLUTICASONE PROPIONATE
  • NEUTROPHILIC INFLAMMATION
  • DYNAMIC HYPERINFLATION

Cite this

Beeh, K. M., Burgel, P-R., Franssen, F. M. E., Luis Lopez-Campos, J., Loukides, S., Hurst, J. R., Flezar, M., Ulrik, C. S., Di Marco, F., Stolz, D., Valipour, A., Casserly, B., Stallberg, B., Kostikas, K., & Wedzicha, J. A. (2017). How Do Dual Long-Acting Bronchodilators Prevent Exacerbations of Chronic Obstructive Pulmonary Disease? American Journal of Respiratory and Critical Care Medicine, 196(2), 139-149. https://doi.org/10.1164/rccm.201609-1794CI