How cardiac myofibers keep pace : mathematical modeling of adaptive myofiber reorientation and electromechanics

In order to improve the diagnosis and management of heart failure, Pluijmert developed a 3D computer model of the human right and left ventricles. Next, tests on the CRT pacemaker were carried out, deciding the best position for the left ventricular electrode in particular. A CRT pacemaker has little or no effect in one-third of the patients who are eligible for this method. It was shown that the ability to pump blood was increased most when activation of the entire left ventricle took place as quickly as possible. This result could be achieved by placing the electrode in the middle of the left ventricular free wall. This is a different position from the one included in the current European and American guidelines on CRT.