Hospital-based cluster randomised controlled trial to assess effects of a multi-faceted programme on influenza vaccine coverage among hospital healthcare workers and nosocomial influenza in the Netherlands, 2009 to 2011

J. Riphagen-Dalhuisen*, J. G. Burgerhof, G. Frijstein, A. D. van der Geest-Blankert, M. B. Danhof-Pont, H. J. de Jager, A. A. Bos, E. E. Smeets, M. J. de Vries, P. M. Gallee, E. Hak

*Corresponding author for this work

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Nosocomial influenza is a large burden in hospitals. Despite recommendations from the World Health Organization to vaccinate healthcare workers against influenza, vaccine uptake remains low in most European countries. We performed a pragmatic cluster randomised controlled trial in order to assess the effects of implementing a multi-faceted influenza immunisation programme on vaccine coverage in hospital healthcare workers (HCWs) and on in-patient morbidity. We included hospital HCWs of three intervention and three control University Medical Centers (UMCs), and 3,367 patients. An implementation programme was offered to the intervention UMCs to assess the effects on both vaccine uptake among hospital staff and patient morbidity. In 2009/10, the coverage of seasonal, the first and second dose of pandemic influenza vaccine as well as seasonal vaccine in 2010/11 was higher in intervention UMCs than control UMCs (all p
Original languageEnglish
Pages (from-to)10-19
Issue number26
Publication statusPublished - 27 Jun 2013

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