Homoarginine and mortality in an older population: the Hoorn study

Stefan Pilz; Tom Teerlink; Peter G. Scheffer; Andreas Meinitzer; Femke Rutters; Andreas Tomaschitz; Christiane Drechsler; Katharina Kienreich; Giel Nijpels; Coen D. A. Stehouwer; Winfried Maerz; Jacqueline M. Dekker

doi:10.1111/eci.12208

Homoarginine and mortality in an older population: the Hoorn study

Stefan Pilz^*, Tom Teerlink, Peter G. Scheffer, Andreas Meinitzer, Femke Rutters, Andreas Tomaschitz, Christiane Drechsler, Katharina Kienreich, Giel Nijpels, Coen D. A. Stehouwer, Winfried Maerz, Jacqueline M. Dekker

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Homoarginine is an amino acid that may be involved in nitric oxide and energy metabolism. Previous studies in patient populations showed that low homoarginine levels indicate an increased risk of mortality and cardiovascular disease. We evaluated whether low plasma levels of homoarginine are associated with elevated, overall and cause-specific mortality. Materials and methods The Hoorn study is a population-based study among older men and women. We calculated Cox proportional hazard ratios (HRs) for overall and cause-specific mortality according to sex-specific homoarginine quartiles. Results We included 606 study participants (513% women; 70066years). Homoarginine concentrations were higher in men (163 +/- 051M), compared with women (130 +/- 044M; P

Original language	English
Pages (from-to)	200-208
Journal	European Journal of Clinical Investigation
Volume	44
Issue number	2
DOIs	https://doi.org/10.1111/eci.12208
Publication status	Published - Feb 2014

Keywords

AMINO acids
cardiovascular
homoarginine
mortality
prospective

Access to Document

10.1111/eci.12208

Cite this

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title = "Homoarginine and mortality in an older population: the Hoorn study",

abstract = "Background Homoarginine is an amino acid that may be involved in nitric oxide and energy metabolism. Previous studies in patient populations showed that low homoarginine levels indicate an increased risk of mortality and cardiovascular disease. We evaluated whether low plasma levels of homoarginine are associated with elevated, overall and cause-specific mortality. Materials and methods The Hoorn study is a population-based study among older men and women. We calculated Cox proportional hazard ratios (HRs) for overall and cause-specific mortality according to sex-specific homoarginine quartiles. Results We included 606 study participants (513% women; 70066years). Homoarginine concentrations were higher in men (163 +/- 051M), compared with women (130 +/- 044M; P",

keywords = "AMINO acids, cardiovascular, homoarginine, mortality, prospective",

author = "Stefan Pilz and Tom Teerlink and Scheffer, {Peter G.} and Andreas Meinitzer and Femke Rutters and Andreas Tomaschitz and Christiane Drechsler and Katharina Kienreich and Giel Nijpels and Stehouwer, {Coen D. A.} and Winfried Maerz and Dekker, {Jacqueline M.}",

year = "2014",

month = feb,

doi = "10.1111/eci.12208",

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volume = "44",

pages = "200--208",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

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TY - JOUR

T1 - Homoarginine and mortality in an older population: the Hoorn study

AU - Pilz, Stefan

AU - Teerlink, Tom

AU - Scheffer, Peter G.

AU - Meinitzer, Andreas

AU - Rutters, Femke

AU - Tomaschitz, Andreas

AU - Drechsler, Christiane

AU - Kienreich, Katharina

AU - Nijpels, Giel

AU - Stehouwer, Coen D. A.

AU - Maerz, Winfried

AU - Dekker, Jacqueline M.

PY - 2014/2

Y1 - 2014/2

N2 - Background Homoarginine is an amino acid that may be involved in nitric oxide and energy metabolism. Previous studies in patient populations showed that low homoarginine levels indicate an increased risk of mortality and cardiovascular disease. We evaluated whether low plasma levels of homoarginine are associated with elevated, overall and cause-specific mortality. Materials and methods The Hoorn study is a population-based study among older men and women. We calculated Cox proportional hazard ratios (HRs) for overall and cause-specific mortality according to sex-specific homoarginine quartiles. Results We included 606 study participants (513% women; 70066years). Homoarginine concentrations were higher in men (163 +/- 051M), compared with women (130 +/- 044M; P

AB - Background Homoarginine is an amino acid that may be involved in nitric oxide and energy metabolism. Previous studies in patient populations showed that low homoarginine levels indicate an increased risk of mortality and cardiovascular disease. We evaluated whether low plasma levels of homoarginine are associated with elevated, overall and cause-specific mortality. Materials and methods The Hoorn study is a population-based study among older men and women. We calculated Cox proportional hazard ratios (HRs) for overall and cause-specific mortality according to sex-specific homoarginine quartiles. Results We included 606 study participants (513% women; 70066years). Homoarginine concentrations were higher in men (163 +/- 051M), compared with women (130 +/- 044M; P

KW - AMINO acids

KW - cardiovascular

KW - homoarginine

KW - mortality

KW - prospective

U2 - 10.1111/eci.12208

DO - 10.1111/eci.12208

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SN - 0014-2972

VL - 44

SP - 200

EP - 208

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

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