Abstract
Background: Gestational diabetes mellitus (GDM) complicates 1-14% of pregnancies and relates to increased risk of adverse obstetric outcomes. Currently GDM is diagnosed using an oral glucose tolerance test (OGTT), which is burdensome and time intensive.Objective: To compare current literature on whether the homeostatic model assessment beta cell function (HOMA-) is an accurate predictor of an abnormal OGTT in pregnant women.Methods: Pubmed, Cochrane and Embase were searched. Included studies evaluated pregnant women at risk for GDM using the homeostatic model assessment of beta cell function (HOMA-) for the assessment of beta cell function and the OGTT. Studies with animals, non-pregnant women, women with type 2 diabetes and post-partum diabetes were excluded. The QUADAS-2 criteria were used to assess the methodological quality of studies.Results: A total of 12 studies were included, reporting on 7292 women. Seven studies showed a difference in beta cell function between women with impaired glucose tolerance compared to healthy pregnant women. HOMA- is significantly lower in impaired glucose tolerance (p
Original language | English |
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Pages (from-to) | 911-917 |
Number of pages | 7 |
Journal | Gynecological Endocrinology |
Volume | 33 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2017 |
Keywords
- Gestational diabetes
- beta cell function
- insulin secreting cells
- homeostatic model assessment
- HOMA
- prediction
- insulin resistance
- GESTATIONAL DIABETES-MELLITUS
- INSULIN-RESISTANCE
- WOMEN
- OUTCOMES
- PREVALENCE
- RECOMMENDATIONS
- HYPERGLYCEMIA
- SENSITIVITY
- CAUCASIANS
- SECRETION