Homeostatic model assessment of beta cell function predicting abnormal oral glucose tolerance testing in pregnancy: a systematic review and meta-analysis

Jonas Ellerbrock*, Jolijn M. H. A. Bohnen, Veronica A. Lopes van Balen, Eva G. Mulder, Robert Aardenburg, Marc E. A. Spaanderman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Web of Science)

Abstract

Background: Gestational diabetes mellitus (GDM) complicates 1-14% of pregnancies and relates to increased risk of adverse obstetric outcomes. Currently GDM is diagnosed using an oral glucose tolerance test (OGTT), which is burdensome and time intensive.Objective: To compare current literature on whether the homeostatic model assessment beta cell function (HOMA-) is an accurate predictor of an abnormal OGTT in pregnant women.Methods: Pubmed, Cochrane and Embase were searched. Included studies evaluated pregnant women at risk for GDM using the homeostatic model assessment of beta cell function (HOMA-) for the assessment of beta cell function and the OGTT. Studies with animals, non-pregnant women, women with type 2 diabetes and post-partum diabetes were excluded. The QUADAS-2 criteria were used to assess the methodological quality of studies.Results: A total of 12 studies were included, reporting on 7292 women. Seven studies showed a difference in beta cell function between women with impaired glucose tolerance compared to healthy pregnant women. HOMA- is significantly lower in impaired glucose tolerance (p

Original languageEnglish
Pages (from-to)911-917
Number of pages7
JournalGynecological Endocrinology
Volume33
Issue number12
DOIs
Publication statusPublished - 2017

Keywords

  • Gestational diabetes
  • beta cell function
  • insulin secreting cells
  • homeostatic model assessment
  • HOMA
  • prediction
  • insulin resistance
  • GESTATIONAL DIABETES-MELLITUS
  • INSULIN-RESISTANCE
  • WOMEN
  • OUTCOMES
  • PREVALENCE
  • RECOMMENDATIONS
  • HYPERGLYCEMIA
  • SENSITIVITY
  • CAUCASIANS
  • SECRETION

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