HLA frequencies and associations in cystic fibrosis

M.P. Adriaanse, A.C. Vreugdenhil, M. Groeneweg, H.T. Bruggenwirth, S.J. Castelijns, C.K. van der Ent, C.E. Voorter, M G. Tilanus

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Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalTissue Antigens
Issue number1
Publication statusPublished - 1 Jan 2014


  • cystic fibrosis
  • cystic fibrosis transmembrane conductance regulator
  • HLA antigens
  • HLA-DQ alpha-chains
  • HLA-DQ beta-chains
  • HLA-DRB1 chains

Cite this

Adriaanse, M. P., Vreugdenhil, A. C., Groeneweg, M., Bruggenwirth, H. T., Castelijns, S. J., van der Ent, C. K., Voorter, C. E., & Tilanus, M. G. (2014). HLA frequencies and associations in cystic fibrosis. Tissue Antigens, 83(1), 27-31. https://doi.org/10.1111/tan.12265