Hippocampal pattern separation of emotional information determining risk or resilience in individuals exposed to childhood trauma: Linking exposure to neurodevelopmental alterations and threat anticipation

Aleksandra Lecei, Ruud van Winkel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)160-170
Number of pages11
JournalNeuroscience and Biobehavioral Reviews
Volume108
DOIs
Publication statusPublished - Jan 2020

Keywords

  • Childhood trauma
  • Maltreatment
  • Adversity
  • Hippocampus
  • Amygdala
  • Pattern separation
  • Episodic memory
  • Emotional modulation
  • DG
  • CA3
  • Threat anticipation
  • Fear generalization
  • Stress
  • Resilience
  • POSTTRAUMATIC-STRESS-DISORDER
  • LONG-TERM POTENTIATION
  • PROLONGED GLUCOCORTICOID EXPOSURE
  • LEARNING-THEORY PERSPECTIVE
  • DENTATE GYRUS
  • PREFRONTAL CORTEX
  • BASOLATERAL AMYGDALA
  • VOLUME REDUCTION
  • GRANULE CELLS
  • FREQUENCY STIMULATION

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