Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice

Tatyana Strekalova*, Dmitrii Pavlov, Alexander Trofimov, Daniel C Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, Raymond Cespuglio

*Corresponding author for this work

Research output: Contribution to journalArticleAcademic

Original languageEnglish
Article number2061
Number of pages22
JournalInternational journal of molecular sciences
Volume23
Issue number4
DOIs
Publication statusPublished - 13 Feb 2022

Keywords

  • Anhedonia/drug effects
  • Animals
  • Antidepressive Agents/pharmacology
  • Celecoxib/pharmacology
  • Citalopram/pharmacology
  • Cyclooxygenase 2/metabolism
  • Depression/drug therapy
  • Hindlimb Suspension/physiology
  • Hippocampus/drug effects
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Rats
  • Rats, Wistar
  • Serotonin Uptake Inhibitors/pharmacology
  • Stress, Psychological/drug therapy
  • Swimming/physiology
  • fear conditioning
  • celecoxib
  • AMPA-RECEPTORS
  • mouse
  • MESSENGER-RNA
  • stress resilience
  • ANIMAL-MODELS
  • citalopram
  • UP-REGULATION
  • major depression
  • INDUCIBLE CYCLOOXYGENASE
  • hippocampus
  • INHIBITOR CELECOXIB
  • DEPRESSIVE SYMPTOMS
  • PREFRONTAL CORTEX
  • inducible cyclooxygenase-2 (COX-2)
  • NONSTEROIDAL ANTIINFLAMMATORY DRUGS
  • anhedonia
  • DOUBLE-BLIND
  • chronic stress

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