Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination

A. M. C. M. Doedee; N. Kannegieter; K. Ozturk; H. van Loveren; R. Janssen; A. M. Buisman

doi:10.1016/j.vaccine.2015.12.027

Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination

A. M. C. M. Doedee^*
, N. Kannegieter
, K. Ozturk
, H. van Loveren
, R. Janssen
, A. M. Buisman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In the present study, differences in hepatitis B surface antigen (HBsAg)-specific memory B-cell responses between low and high responders to hepatitis B vaccine (HepB), based on levels of antibodies against HBsAg (anti-HBs), were determined. In addition, HBsAg specific T-cell responses between high (anti-HBs level >20,000 IU/L) and low (anti-HBs level

Original language	English
Pages (from-to)	2281-2289
Number of pages	9
Journal	Vaccine
Volume	34
Issue number	19
DOIs	https://doi.org/10.1016/j.vaccine.2015.12.027
Publication status	Published - 27 Apr 2016

Keywords

Hepatitis B vaccination
Low and high responders
Anti-HBs levels
HBsAg-specific memory B-cells
HBsAg-specific memory T-cells
IL-13

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10.1016/j.vaccine.2015.12.027

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title = "Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination",

abstract = "In the present study, differences in hepatitis B surface antigen (HBsAg)-specific memory B-cell responses between low and high responders to hepatitis B vaccine (HepB), based on levels of antibodies against HBsAg (anti-HBs), were determined. In addition, HBsAg specific T-cell responses between high (anti-HBs level >20,000 IU/L) and low (anti-HBs level ",

keywords = "Hepatitis B vaccination, Low and high responders, Anti-HBs levels, HBsAg-specific memory B-cells, HBsAg-specific memory T-cells, IL-13",

author = "Doedee, \{A. M. C. M.\} and N. Kannegieter and K. Ozturk and \{van Loveren\}, H. and R. Janssen and Buisman, \{A. M.\}",

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doi = "10.1016/j.vaccine.2015.12.027",

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T1 - Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination

AU - Doedee, A. M. C. M.

AU - Kannegieter, N.

AU - Ozturk, K.

AU - van Loveren, H.

AU - Janssen, R.

AU - Buisman, A. M.

PY - 2016/4/27

Y1 - 2016/4/27

N2 - In the present study, differences in hepatitis B surface antigen (HBsAg)-specific memory B-cell responses between low and high responders to hepatitis B vaccine (HepB), based on levels of antibodies against HBsAg (anti-HBs), were determined. In addition, HBsAg specific T-cell responses between high (anti-HBs level >20,000 IU/L) and low (anti-HBs level

AB - In the present study, differences in hepatitis B surface antigen (HBsAg)-specific memory B-cell responses between low and high responders to hepatitis B vaccine (HepB), based on levels of antibodies against HBsAg (anti-HBs), were determined. In addition, HBsAg specific T-cell responses between high (anti-HBs level >20,000 IU/L) and low (anti-HBs level

KW - Hepatitis B vaccination

KW - Low and high responders

KW - Anti-HBs levels

KW - HBsAg-specific memory B-cells

KW - HBsAg-specific memory T-cells

KW - IL-13

U2 - 10.1016/j.vaccine.2015.12.027

DO - 10.1016/j.vaccine.2015.12.027

M3 - Article

C2 - 26721327

SN - 0264-410X

VL - 34

SP - 2281

EP - 2289

JO - Vaccine

JF - Vaccine

IS - 19

ER -

Higher numbers of memory B-cells and Th2-cytokine skewing in high responders to hepatitis B vaccination

Abstract

Keywords

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