TY - JOUR
T1 - High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology
AU - Yang, Liangliang
AU - Pijuan-Galito, Sara
AU - Rho, Hoon Suk
AU - Vasilevich, Aliaksei S.
AU - Eren, Aysegul Dede
AU - Ge, Lu
AU - Habibovic, Pamela
AU - Alexander, Morgan R.
AU - de Boer, Jan
AU - Carlier, Aurelie
AU - van Rijn, Patrick
AU - Zhou, Qihui
N1 - Funding Information:
The authors are very grateful for financial support of by the National Natural Science Foundation of China (Grant No. 31900957), Shandong Provincial Natural Science Foundation (Grant No. ZR2019QC007), China Postdoctoral Science Foundation (Grant No. 2019M652326), Innovation and technology program for the excellent youth scholars of higher education of Shandong province (Grant No. 2019KJE015), Key Laboratory of Tianjin Hyaluronic Acid Application Research Enterprise (Grant No. KTRDHA-Y201902), the Scientific Research Foundation of Qingdao University (Grant No. DC1900009689), the China Scholarship Council (Grant Nos. 201608310113, 201707720058, and 201406630003), the Wellcome Trust (Sir Henry Wellcome Postdoctoral Fellowship, 201457/Z/16/Z), the European Union’s Horizon 2020 Programme (H2020-MSCA-ITN-2015; Grant Agreement No. 676338), The Netherlands Organisation for Scientific Research Vidi grant (15604) and the Dutch Province of Limburg (LINK project), the Gravitation Program ‘Materials-Driven Regeneration’ funded by The Netherlands Organisation for Scientific Research (024.003.013), the Dutch province of Limburg in the LINK (FCL67723) (“Limburg INvesteert in haar Kenniseconomie”) knowledge economy project, and a VENI grant (No. 15075) from the Dutch Science Foundation (NWO).
Publisher Copyright:
© 2021 The Authors. Published by American Chemical Society.
PY - 2021/4/28
Y1 - 2021/4/28
N2 - The complex interaction of cells with biomaterials (i.e., materiobiology) plays an increasingly pivotal role in the development of novel implants, biomedical devices, and tissue engineering scaffolds to treat diseases, aid in the restoration of bodily functions, construct healthy tissues, or regenerate diseased ones. However, the conventional approaches are incapable of screening the huge amount of potential material parameter combinations to identify the optimal cell responses and involve a combination of serendipity and many series of trial-and-error experiments. For advanced tissue engineering and regenerative medicine, highly efficient and complex bioanalysis platforms are expected to explore the complex interaction of cells with biomaterials using combinatorial approaches that offer desired complex microenvironments during healing, development, and homeostasis. In this review, we first introduce materiobiology and its high-throughput screening (HTS). Then we present an in-depth of the recent progress of 2D/3D HTS platforms (i.e., gradient and microarray) in the principle, preparation, screening for materiobiology, and combination with other advanced technologies. The Compendium for Biomaterial Transcriptomics and high content imaging, computational simulations, and their translation toward commercial and clinical uses are highlighted. In the final section, current challenges and future perspectives are discussed. High-throughput experimentation within the field of materiobiology enables the elucidation of the relationships between biomaterial properties and biological behavior and thereby serves as a potential tool for accelerating the development of high-performance biomaterials.
AB - The complex interaction of cells with biomaterials (i.e., materiobiology) plays an increasingly pivotal role in the development of novel implants, biomedical devices, and tissue engineering scaffolds to treat diseases, aid in the restoration of bodily functions, construct healthy tissues, or regenerate diseased ones. However, the conventional approaches are incapable of screening the huge amount of potential material parameter combinations to identify the optimal cell responses and involve a combination of serendipity and many series of trial-and-error experiments. For advanced tissue engineering and regenerative medicine, highly efficient and complex bioanalysis platforms are expected to explore the complex interaction of cells with biomaterials using combinatorial approaches that offer desired complex microenvironments during healing, development, and homeostasis. In this review, we first introduce materiobiology and its high-throughput screening (HTS). Then we present an in-depth of the recent progress of 2D/3D HTS platforms (i.e., gradient and microarray) in the principle, preparation, screening for materiobiology, and combination with other advanced technologies. The Compendium for Biomaterial Transcriptomics and high content imaging, computational simulations, and their translation toward commercial and clinical uses are highlighted. In the final section, current challenges and future perspectives are discussed. High-throughput experimentation within the field of materiobiology enables the elucidation of the relationships between biomaterial properties and biological behavior and thereby serves as a potential tool for accelerating the development of high-performance biomaterials.
KW - COMPLEMENTARY DENSITY GRADIENT
KW - FOREIGN-BODY RESPONSE
KW - GROWTH-FACTOR GRADIENTS
KW - MESENCHYMAL STEM-CELLS
KW - ON-A-CHIP
KW - PORE-SIZE GRADIENTS
KW - SELF-ASSEMBLED MONOLAYERS
KW - SERUM-ALBUMIN ADSORPTION
KW - SMOOTH-MUSCLE-CELLS
KW - SURFACE-CHEMISTRY GRADIENTS
KW - SINGLE CANCER-CELLS
U2 - 10.1021/acs.chemrev.0c00752
DO - 10.1021/acs.chemrev.0c00752
M3 - (Systematic) Review article
C2 - 33705116
SN - 0009-2665
VL - 121
SP - 4561
EP - 4677
JO - Chemical Reviews
JF - Chemical Reviews
IS - 8
ER -