High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Steven Hiemstra, Sreenivasa C. Ramaiahgari, Steven Wink, Giulia Callegaro, Maarten Coonen, John Meerman, Danyel Jennen, Karen van den Nieuwendijk, Anita Dankers, Jan Snoeys, Hans de Bont, Leo Price, Bob van de Water*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)2895-2911
Number of pages17
JournalArchives of Toxicology
Volume93
Issue number10
DOIs
Publication statusPublished - Oct 2019

Keywords

  • High-throughput imaging
  • HepG2 spheroids
  • Drug-induced liver injury
  • BAC-reporter cells
  • Cellular stress response
  • Liver transcription factors
  • IN-VITRO
  • GENE-TRANSCRIPTION
  • TOXICITY
  • MECHANISMS
  • INHIBITION
  • FAILURE
  • PATHWAY
  • MODELS
  • RISK

Cite this

Hiemstra, S., Ramaiahgari, S. C., Wink, S., Callegaro, G., Coonen, M., Meerman, J., Jennen, D., van den Nieuwendijk, K., Dankers, A., Snoeys, J., de Bont, H., Price, L., & van de Water, B. (2019). High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. Archives of Toxicology, 93(10), 2895-2911. https://doi.org/10.1007/s00204-019-02552-0