High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Steven Hiemstra; Sreenivasa C. Ramaiahgari; Steven Wink; Giulia Callegaro; Maarten Coonen; John Meerman; Danyel Jennen; Karen van den Nieuwendijk; Anita Dankers; Jan Snoeys; Hans de Bont; Leo Price; Bob van de Water

doi:10.1007/s00204-019-02552-0

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

Steven Hiemstra, Sreenivasa C. Ramaiahgari, Steven Wink, Giulia Callegaro, Maarten Coonen, John Meerman, Danyel Jennen, Karen van den Nieuwendijk, Anita Dankers, Jan Snoeys, Hans de Bont, Leo Price, Bob van de Water^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	2895-2911
Number of pages	17
Journal	Archives of Toxicology
Volume	93
Issue number	10
DOIs	https://doi.org/10.1007/s00204-019-02552-0
Publication status	Published - Oct 2019

Keywords

High-throughput imaging
HepG2 spheroids
Drug-induced liver injury
BAC-reporter cells
Cellular stress response
Liver transcription factors
IN-VITRO
GENE-TRANSCRIPTION
TOXICITY
MECHANISMS
INHIBITION
FAILURE
PATHWAY
MODELS
RISK

Access to Document

10.1007/s00204-019-02552-0

Cite this

Hiemstra, S., Ramaiahgari, S. C., Wink, S., Callegaro, G., Coonen, M., Meerman, J., Jennen, D., van den Nieuwendijk, K., Dankers, A., Snoeys, J., de Bont, H., Price, L., & van de Water, B. (2019). High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. Archives of Toxicology, 93(10), 2895-2911. https://doi.org/10.1007/s00204-019-02552-0

Hiemstra, Steven ; Ramaiahgari, Sreenivasa C. ; Wink, Steven ; Callegaro, Giulia ; Coonen, Maarten ; Meerman, John ; Jennen, Danyel ; van den Nieuwendijk, Karen ; Dankers, Anita ; Snoeys, Jan ; de Bont, Hans ; Price, Leo ; van de Water, Bob. / High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. In: Archives of Toxicology. 2019 ; Vol. 93, No. 10. pp. 2895-2911.

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title = "High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability",

keywords = "High-throughput imaging, HepG2 spheroids, Drug-induced liver injury, BAC-reporter cells, Cellular stress response, Liver transcription factors, IN-VITRO, GENE-TRANSCRIPTION, TOXICITY, MECHANISMS, INHIBITION, FAILURE, PATHWAY, MODELS, RISK",

author = "Steven Hiemstra and Ramaiahgari, {Sreenivasa C.} and Steven Wink and Giulia Callegaro and Maarten Coonen and John Meerman and Danyel Jennen and {van den Nieuwendijk}, Karen and Anita Dankers and Jan Snoeys and {de Bont}, Hans and Leo Price and {van de Water}, Bob",

year = "2019",

month = oct,

doi = "10.1007/s00204-019-02552-0",

language = "English",

volume = "93",

pages = "2895--2911",

journal = "Archives of Toxicology",

issn = "0340-5761",

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Hiemstra, S, Ramaiahgari, SC, Wink, S, Callegaro, G, Coonen, M, Meerman, J, Jennen, D, van den Nieuwendijk, K, Dankers, A, Snoeys, J, de Bont, H, Price, L & van de Water, B 2019, 'High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability', Archives of Toxicology, vol. 93, no. 10, pp. 2895-2911. https://doi.org/10.1007/s00204-019-02552-0

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability. / Hiemstra, Steven; Ramaiahgari, Sreenivasa C.; Wink, Steven; Callegaro, Giulia; Coonen, Maarten; Meerman, John; Jennen, Danyel; van den Nieuwendijk, Karen; Dankers, Anita; Snoeys, Jan; de Bont, Hans; Price, Leo; van de Water, Bob.

In: Archives of Toxicology, Vol. 93, No. 10, 10.2019, p. 2895-2911.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability

AU - Hiemstra, Steven

AU - Ramaiahgari, Sreenivasa C.

AU - Wink, Steven

AU - Callegaro, Giulia

AU - Coonen, Maarten

AU - Meerman, John

AU - Jennen, Danyel

AU - van den Nieuwendijk, Karen

AU - Dankers, Anita

AU - Snoeys, Jan

AU - de Bont, Hans

AU - Price, Leo

AU - van de Water, Bob

PY - 2019/10

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KW - High-throughput imaging

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KW - Drug-induced liver injury

KW - BAC-reporter cells

KW - Cellular stress response

KW - Liver transcription factors

KW - IN-VITRO

KW - GENE-TRANSCRIPTION

KW - TOXICITY

KW - MECHANISMS

KW - INHIBITION

KW - FAILURE

KW - PATHWAY

KW - MODELS

KW - RISK

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DO - 10.1007/s00204-019-02552-0

M3 - Article

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SP - 2895

EP - 2911

JO - Archives of Toxicology

JF - Archives of Toxicology

SN - 0340-5761

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ER -