TY - JOUR
T1 - High non-responsiveness of males and the elderly to standard hepatitis B vaccination among a large cohort of healthy employees
AU - Vermeiren, Angelique P. A.
AU - Hoebe, Christian J. P. A.
AU - Dukers-Muijrers, Nicole H. T. M.
PY - 2013/9
Y1 - 2013/9
N2 - Background: Hepatitis B virus infection is a major health problem. Although non-response is known to increase with age, hepatitis B vaccinations are considered to have only minor non-response rates (anti-HBs <10 IU/L) in healthy subjects. Objectives: The aim of this study was to quantify immunosenescence in a large retrospective cohort of 11,439 healthy adults who received HBV immunisation according to the standard vaccination regime. Study design: We evaluated the response to the standard three-dose vaccination regimen, consisting of 20-mu g doses of the HbsAg recombinant DNA hepatitis B vaccine, among 11,439 healthy employees using a retrospective cohort design. Logistic regression was applied to predict the non-response rate, and multivariate regression analysis was applied to predict antibody response. Predictors of responsiveness included sex, age and time between the last vaccination and antibody titre measurement. Results: From the age of 29 on in men and 43 on in women, more than 5% of subjects did not respond. Compared with women, men had a higher risk of non-response and exhibited a steeper decline in antibody titres produced with increasing age. Conclusions: This retrospective cohort study demonstrates that immunosenescence starts at young age, especially among men, underlining the importance of vaccination at a young age to achieve long-lasting immunity. Moreover, HBV vaccination should always include testing for antibodies to facilitate the performance of necessary interventions to prevent long-term fatal complications.
AB - Background: Hepatitis B virus infection is a major health problem. Although non-response is known to increase with age, hepatitis B vaccinations are considered to have only minor non-response rates (anti-HBs <10 IU/L) in healthy subjects. Objectives: The aim of this study was to quantify immunosenescence in a large retrospective cohort of 11,439 healthy adults who received HBV immunisation according to the standard vaccination regime. Study design: We evaluated the response to the standard three-dose vaccination regimen, consisting of 20-mu g doses of the HbsAg recombinant DNA hepatitis B vaccine, among 11,439 healthy employees using a retrospective cohort design. Logistic regression was applied to predict the non-response rate, and multivariate regression analysis was applied to predict antibody response. Predictors of responsiveness included sex, age and time between the last vaccination and antibody titre measurement. Results: From the age of 29 on in men and 43 on in women, more than 5% of subjects did not respond. Compared with women, men had a higher risk of non-response and exhibited a steeper decline in antibody titres produced with increasing age. Conclusions: This retrospective cohort study demonstrates that immunosenescence starts at young age, especially among men, underlining the importance of vaccination at a young age to achieve long-lasting immunity. Moreover, HBV vaccination should always include testing for antibodies to facilitate the performance of necessary interventions to prevent long-term fatal complications.
KW - Hepatitis B vaccination
KW - Ageing
KW - Immunosenescence
KW - Immune response
U2 - 10.1016/j.jcv.2013.07.003
DO - 10.1016/j.jcv.2013.07.003
M3 - Article
C2 - 23895931
SN - 1386-6532
VL - 58
SP - 262
EP - 264
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
IS - 1
ER -