High-Density Lipoprotein Modifications: A Pathological Consequence or Cause of Disease Progression?

Andrea Bonnin Marquez, Sumra Nazir, Emiel P. C. van der Vorst*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Web of Science)

Abstract

High-density lipoprotein (HDL) is well-known for its cardioprotective effects, as it possesses anti-inflammatory, anti-oxidative, anti-thrombotic, and cytoprotective properties. Traditionally, studies and therapeutic approaches have focused on raising HDL cholesterol levels. Recently, it became evident that, not HDL cholesterol, but HDL composition and functionality, is probably a more fruitful target. In disorders, such as chronic kidney disease or cardiovascular diseases, it has been observed that HDL is modified and becomes dysfunctional. There are different modification that can occur, such as serum amyloid, an enrichment and oxidation, carbamylation, and glycation of key proteins. Additionally, the composition of HDL can be affected by changes to enzymes such as cholesterol ester transfer protein (CETP), lecithin-cholesterol acyltransferase (LCAT), and phospholipid transfer protein (PLTP) or by modification to other important components. This review will highlight some main modifications to HDL and discuss whether these modifications are purely a consequential result of pathology or are actually involved in the pathology itself and have a causal role. Therefore, HDL composition may present a molecular target for the amelioration of certain diseases, but more information is needed to determine to what extent HDL modifications play a causal role in disease development.

Original languageEnglish
Article number549
Number of pages20
JournalBiomedicines
Volume8
Issue number12
DOIs
Publication statusPublished - Dec 2020

Keywords

  • high-density lipoproteins
  • inflammation
  • HDL modifications
  • dysfunctional HDL
  • APOLIPOPROTEIN-A-I
  • ESTER TRANSFER PROTEIN
  • SERUM AMYLOID-A
  • LECITHIN-CHOLESTEROL ACYLTRANSFERASE
  • MESSENGER-RNA LEVELS
  • PARAOXONASE ACTIVITY
  • ANTIINFLAMMATORY PROPERTIES
  • CARDIOVASCULAR-DISEASE
  • RHEUMATOID-ARTHRITIS
  • NLRP3 INFLAMMASOME

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