Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan

Floor H.E. Staal; Walter Noordzij; Jorinde Janssen; Daniëla E. Oprea-Lager; Antoine M. Engelen; Evert J. van Limbergen; Robert Jan Smeenk; Marianne A.A. de Jong; Tom C.G. Budiharto; Inge Jacobs; M. A.Dorien Haverkort; Charlotte L. Brouwer; Kelvin Ng Wei Siang; Johannes A. Langendijk; J. Fred Verzijlbergen; Igle Jan de Jong; Shafak Aluwini

doi:10.1007/s13629-024-00424-6

Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan

Translated title of the contribution: The pattern of local recurrence after prostatectomy on PSMA PET/CT-scan

Floor H.E. Staal^*
, Walter Noordzij
, Jorinde Janssen
, Daniëla E. Oprea-Lager
, Antoine M. Engelen
, Evert J. van Limbergen
, Robert Jan Smeenk
, Marianne A.A. de Jong
, Tom C.G. Budiharto
, Inge Jacobs
, M. A.Dorien Haverkort
, Charlotte L. Brouwer
, Kelvin Ng Wei Siang
, Johannes A. Langendijk
, J. Fred Verzijlbergen
, Igle Jan de Jong
, Shafak Aluwini

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This study aimed to describe the local recurrence (LR) pattern in post-prostatectomy prostate cancer patients using PSMA PET/CT scans. We retrospectively collected 103 PSMA PET/CT scans from patients with suspected LR across nine medical centres. Anonymized scans underwent review by an expert nuclear medicine physician. After review, on 83 PSMA PET/CT scans, 93 lesions were identified as a LR. The predominant LR location (56%) was found within 2 cm cranial to the penile bulb. Additionally, 24 LR (26%) were observed > 2 cm cranial to the penile bulb and caudal to the top of the pubic bone. Only 17 LR (18%) occurred cranial to the symphysis pubis. These findings contribute to the understanding of LR pattern post-prostatectomy, potentially optimizing accurate salvage radiotherapy to the prostate bed.

Translated title of the contribution	The pattern of local recurrence after prostatectomy on PSMA PET/CT-scan
Original language	Dutch
Pages (from-to)	85-90
Number of pages	6
Journal	Tijdschrift voor Urologie
Volume	14
Issue number	4
Early online date	14 Feb 2024
DOIs	https://doi.org/10.1007/s13629-024-00424-6
Publication status	Published - Jul 2024

Keywords

Local recurrence
Prostate bed
Prostatectomy
PSMA PET/CT
Salvage radiotherapy
Target volume

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Staal, F. H. E., Noordzij, W., Janssen, J., Oprea-Lager, D. E., Engelen, A. M., van Limbergen, E. J., Smeenk, R. J., de Jong, M. A. A., Budiharto, T. C. G., Jacobs, I., Haverkort, M. A. D., Brouwer, C. L., Wei Siang, K. N., Langendijk, J. A., Verzijlbergen, J. F., de Jong, I. J., & Aluwini, S. (2024). Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan. Tijdschrift voor Urologie, 14(4), 85-90. https://doi.org/10.1007/s13629-024-00424-6

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title = "Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan",

abstract = "This study aimed to describe the local recurrence (LR) pattern in post-prostatectomy prostate cancer patients using PSMA PET/CT scans. We retrospectively collected 103 PSMA PET/CT scans from patients with suspected LR across nine medical centres. Anonymized scans underwent review by an expert nuclear medicine physician. After review, on 83 PSMA PET/CT scans, 93 lesions were identified as a LR. The predominant LR location (56\%) was found within 2 cm cranial to the penile bulb. Additionally, 24 LR (26\%) were observed > 2 cm cranial to the penile bulb and caudal to the top of the pubic bone. Only 17 LR (18\%) occurred cranial to the symphysis pubis. These findings contribute to the understanding of LR pattern post-prostatectomy, potentially optimizing accurate salvage radiotherapy to the prostate bed.",

keywords = "Local recurrence, Prostate bed, Prostatectomy, PSMA PET/CT, Salvage radiotherapy, Target volume",

author = "Staal, \{Floor H.E.\} and Walter Noordzij and Jorinde Janssen and Oprea-Lager, \{Dani{\"e}la E.\} and Engelen, \{Antoine M.\} and \{van Limbergen\}, \{Evert J.\} and Smeenk, \{Robert Jan\} and \{de Jong\}, \{Marianne A.A.\} and Budiharto, \{Tom C.G.\} and Inge Jacobs and Haverkort, \{M. A.Dorien\} and Brouwer, \{Charlotte L.\} and \{Wei Siang\}, \{Kelvin Ng\} and Langendijk, \{Johannes A.\} and Verzijlbergen, \{J. Fred\} and \{de Jong\}, \{Igle Jan\} and Shafak Aluwini",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = jul,

doi = "10.1007/s13629-024-00424-6",

language = "Dutch",

volume = "14",

pages = "85--90",

journal = "Tijdschrift voor Urologie",

issn = "2211-3037",

publisher = "Springer Science + Business Media",

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}

Staal, FHE, Noordzij, W, Janssen, J, Oprea-Lager, DE, Engelen, AM, van Limbergen, EJ, Smeenk, RJ, de Jong, MAA, Budiharto, TCG, Jacobs, I, Haverkort, MAD, Brouwer, CL, Wei Siang, KN, Langendijk, JA, Verzijlbergen, JF, de Jong, IJ & Aluwini, S 2024, 'Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan', Tijdschrift voor Urologie, vol. 14, no. 4, pp. 85-90. https://doi.org/10.1007/s13629-024-00424-6

TY - JOUR

T1 - Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan

AU - Staal, Floor H.E.

AU - Noordzij, Walter

AU - Janssen, Jorinde

AU - Oprea-Lager, Daniëla E.

AU - Engelen, Antoine M.

AU - van Limbergen, Evert J.

AU - Smeenk, Robert Jan

AU - de Jong, Marianne A.A.

AU - Budiharto, Tom C.G.

AU - Jacobs, Inge

AU - Haverkort, M. A.Dorien

AU - Brouwer, Charlotte L.

AU - Wei Siang, Kelvin Ng

AU - Langendijk, Johannes A.

AU - Verzijlbergen, J. Fred

AU - de Jong, Igle Jan

AU - Aluwini, Shafak

PY - 2024/7

Y1 - 2024/7

N2 - This study aimed to describe the local recurrence (LR) pattern in post-prostatectomy prostate cancer patients using PSMA PET/CT scans. We retrospectively collected 103 PSMA PET/CT scans from patients with suspected LR across nine medical centres. Anonymized scans underwent review by an expert nuclear medicine physician. After review, on 83 PSMA PET/CT scans, 93 lesions were identified as a LR. The predominant LR location (56%) was found within 2 cm cranial to the penile bulb. Additionally, 24 LR (26%) were observed > 2 cm cranial to the penile bulb and caudal to the top of the pubic bone. Only 17 LR (18%) occurred cranial to the symphysis pubis. These findings contribute to the understanding of LR pattern post-prostatectomy, potentially optimizing accurate salvage radiotherapy to the prostate bed.

AB - This study aimed to describe the local recurrence (LR) pattern in post-prostatectomy prostate cancer patients using PSMA PET/CT scans. We retrospectively collected 103 PSMA PET/CT scans from patients with suspected LR across nine medical centres. Anonymized scans underwent review by an expert nuclear medicine physician. After review, on 83 PSMA PET/CT scans, 93 lesions were identified as a LR. The predominant LR location (56%) was found within 2 cm cranial to the penile bulb. Additionally, 24 LR (26%) were observed > 2 cm cranial to the penile bulb and caudal to the top of the pubic bone. Only 17 LR (18%) occurred cranial to the symphysis pubis. These findings contribute to the understanding of LR pattern post-prostatectomy, potentially optimizing accurate salvage radiotherapy to the prostate bed.

KW - Local recurrence

KW - Prostate bed

KW - Prostatectomy

KW - PSMA PET/CT

KW - Salvage radiotherapy

KW - Target volume

U2 - 10.1007/s13629-024-00424-6

DO - 10.1007/s13629-024-00424-6

M3 - Article

SN - 2211-3037

VL - 14

SP - 85

EP - 90

JO - Tijdschrift voor Urologie

JF - Tijdschrift voor Urologie

IS - 4

ER -

Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan

Abstract

Keywords

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