Hesperidin Functions as an Ergogenic Aid by Increasing Endothelial Function and Decreasing Exercise-Induced Oxidative Stress and Inflammation, Thereby Contributing to Improved Exercise Performance

M. Imperatrice*, I. Cuijpers*, F.J. Troost, M.M.J.P.E. Sthijns

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

The regulation of blood flow to peripheral muscles is crucial for proper skeletal muscle functioning and exercise performance. During exercise, increased mitochondrial oxidative phosphorylation leads to increased electron leakage and consequently induces an increase in ROS formation, contributing to DNA, lipid, and protein damage. Moreover, exercise may increase blood- and intramuscular inflammatory factors leading to a deterioration in endurance performance. The aim of this review is to investigate the potential mechanisms through which the polyphenol hesperidin could lead to enhanced exercise performance, namely improved endothelial function, reduced exercise-induced oxidative stress, and inflammation. We selected in vivo RCTs, animal studies, and in vitro studies in which hesperidin, its aglycone form hesperetin, hesperetin-metabolites, or orange juice are supplemented at any dosage and where the parameters related to endothelial function, oxidative stress, and/or inflammation have been measured. The results collected in this review show that hesperidin improves endothelial function (via increased NO availability), inhibits ROS production, decreases production and plasma levels of pro-inflammatory markers, and improves anaerobic exercise outcomes (e.g., power, speed, energy). For elite and recreational athletes, hesperidin could be used as an ergogenic aid to enhance muscle recovery between training sessions, optimize oxygen and nutrient supplies to the muscles, and improve anaerobic performance.
Original languageEnglish
Article number2955
Number of pages25
JournalNutrients
Volume14
Issue number14
DOIs
Publication statusPublished - 1 Jul 2022

Keywords

  • hesperidin
  • citrus flavanones
  • polyphenols
  • antioxidant
  • physical activity
  • exercise performance
  • ergogenic aids
  • endothelial dysfunction
  • ONSET MUSCLE SORENESS
  • CITRUS FLAVONOID HESPERIDIN
  • NITRIC-OXIDE
  • ORANGE JUICE
  • ANTIINFLAMMATORY PROPERTIES
  • GLUCOSYL HESPERIDIN
  • ADHESION MOLECULES
  • PHYSICAL-EXERCISE
  • BLOOD-FLOW
  • SUPPLEMENTATION

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