Heritability of ambulatory and office blood pressure in the Swiss population

Heba Alwan; Georg Ehret; Belen Ponte; Menno Pruijm; Daniel Ackermann; Idris Guessous; Jan A. Staessen; Kei Asayama; Zoltan Kutalik; Philippe Vuistiner; Fred Paccaud; Antoinette Pechere-Bertschi; Markus Mohaupt; Bruno Vogt; Pierre-Yves Martin; Michel Burnier; Murielle Bochud

doi:10.1097/HJH.0000000000000681

Heritability of ambulatory and office blood pressure in the Swiss population

Heba Alwan, Georg Ehret, Belen Ponte, Menno Pruijm, Daniel Ackermann, Idris Guessous, Jan A. Staessen, Kei Asayama, Zoltan Kutalik, Philippe Vuistiner, Fred Paccaud, Antoinette Pechere-Bertschi, Markus Mohaupt, Bruno Vogt, Pierre-Yves Martin, Michel Burnier, Murielle Bochud^*

^*Corresponding author for this work

Epidemiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background:Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.Methods:The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.Results:The 518 women and 491 men included in this analysis had a mean (SD) age of 48.3 (+/- 17.4) and 47.3 (+/- 17.7) years, and a mean BMI of 23.8 (+/- 4.2) and 25.9 (+/- 4.1) kg/m(2), respectively. Narrow-sense heritability estimates (+/- standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 +/- 0.07, 0.26 +/- 0.07, and 0.29 +/- 0.07 for 24-h BP; 0.39 +/- 0.07, 0.28 +/- 0.07, and 0.27 +/- 0.07 for day BP; and 0.25 +/- 0.07, 0.20 +/- 0.07, and 0.30 +/- 0.07 for night BP, respectively (all P

Original language	English
Pages (from-to)	2061-2067
Journal	Journal of Hypertension
Volume	33
Issue number	10
DOIs	https://doi.org/10.1097/HJH.0000000000000681
Publication status	Published - Oct 2015

Keywords

ambulatory blood pressure
cross-sectional
heritability
population

Access to Document

10.1097/HJH.0000000000000681

Cite this

Alwan, H., Ehret, G., Ponte, B., Pruijm, M., Ackermann, D., Guessous, I., Staessen, J. A., Asayama, K., Kutalik, Z., Vuistiner, P., Paccaud, F., Pechere-Bertschi, A., Mohaupt, M., Vogt, B., Martin, P.-Y., Burnier, M., & Bochud, M. (2015). Heritability of ambulatory and office blood pressure in the Swiss population. Journal of Hypertension, 33(10), 2061-2067. https://doi.org/10.1097/HJH.0000000000000681

@article{4988f7f1d91e48d891ed9fc7a8788fc9,

title = "Heritability of ambulatory and office blood pressure in the Swiss population",

abstract = "Background:Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.Methods:The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.Results:The 518 women and 491 men included in this analysis had a mean (SD) age of 48.3 (+/- 17.4) and 47.3 (+/- 17.7) years, and a mean BMI of 23.8 (+/- 4.2) and 25.9 (+/- 4.1) kg/m(2), respectively. Narrow-sense heritability estimates (+/- standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 +/- 0.07, 0.26 +/- 0.07, and 0.29 +/- 0.07 for 24-h BP; 0.39 +/- 0.07, 0.28 +/- 0.07, and 0.27 +/- 0.07 for day BP; and 0.25 +/- 0.07, 0.20 +/- 0.07, and 0.30 +/- 0.07 for night BP, respectively (all P",

keywords = "ambulatory blood pressure, cross-sectional, heritability, population",

author = "Heba Alwan and Georg Ehret and Belen Ponte and Menno Pruijm and Daniel Ackermann and Idris Guessous and Staessen, {Jan A.} and Kei Asayama and Zoltan Kutalik and Philippe Vuistiner and Fred Paccaud and Antoinette Pechere-Bertschi and Markus Mohaupt and Bruno Vogt and Pierre-Yves Martin and Michel Burnier and Murielle Bochud",

year = "2015",

month = oct,

doi = "10.1097/HJH.0000000000000681",

language = "English",

volume = "33",

pages = "2061--2067",

journal = "Journal of Hypertension",

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Alwan, H, Ehret, G, Ponte, B, Pruijm, M, Ackermann, D, Guessous, I, Staessen, JA, Asayama, K, Kutalik, Z, Vuistiner, P, Paccaud, F, Pechere-Bertschi, A, Mohaupt, M, Vogt, B, Martin, P-Y, Burnier, M & Bochud, M 2015, 'Heritability of ambulatory and office blood pressure in the Swiss population', Journal of Hypertension, vol. 33, no. 10, pp. 2061-2067. https://doi.org/10.1097/HJH.0000000000000681

TY - JOUR

T1 - Heritability of ambulatory and office blood pressure in the Swiss population

AU - Alwan, Heba

AU - Ehret, Georg

AU - Ponte, Belen

AU - Pruijm, Menno

AU - Ackermann, Daniel

AU - Guessous, Idris

AU - Staessen, Jan A.

AU - Asayama, Kei

AU - Kutalik, Zoltan

AU - Vuistiner, Philippe

AU - Paccaud, Fred

AU - Pechere-Bertschi, Antoinette

AU - Mohaupt, Markus

AU - Vogt, Bruno

AU - Martin, Pierre-Yves

AU - Burnier, Michel

AU - Bochud, Murielle

PY - 2015/10

Y1 - 2015/10

N2 - Background:Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.Methods:The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.Results:The 518 women and 491 men included in this analysis had a mean (SD) age of 48.3 (+/- 17.4) and 47.3 (+/- 17.7) years, and a mean BMI of 23.8 (+/- 4.2) and 25.9 (+/- 4.1) kg/m(2), respectively. Narrow-sense heritability estimates (+/- standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 +/- 0.07, 0.26 +/- 0.07, and 0.29 +/- 0.07 for 24-h BP; 0.39 +/- 0.07, 0.28 +/- 0.07, and 0.27 +/- 0.07 for day BP; and 0.25 +/- 0.07, 0.20 +/- 0.07, and 0.30 +/- 0.07 for night BP, respectively (all P

AB - Background:Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.Methods:The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.Results:The 518 women and 491 men included in this analysis had a mean (SD) age of 48.3 (+/- 17.4) and 47.3 (+/- 17.7) years, and a mean BMI of 23.8 (+/- 4.2) and 25.9 (+/- 4.1) kg/m(2), respectively. Narrow-sense heritability estimates (+/- standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 +/- 0.07, 0.26 +/- 0.07, and 0.29 +/- 0.07 for 24-h BP; 0.39 +/- 0.07, 0.28 +/- 0.07, and 0.27 +/- 0.07 for day BP; and 0.25 +/- 0.07, 0.20 +/- 0.07, and 0.30 +/- 0.07 for night BP, respectively (all P

KW - ambulatory blood pressure

KW - cross-sectional

KW - heritability

KW - population

U2 - 10.1097/HJH.0000000000000681

DO - 10.1097/HJH.0000000000000681

M3 - Article

C2 - 26203966

SN - 0263-6352

VL - 33

SP - 2061

EP - 2067

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 10

ER -