TY - JOUR
T1 - Heritability of ambulatory and office blood pressure in the Swiss population
AU - Alwan, Heba
AU - Ehret, Georg
AU - Ponte, Belen
AU - Pruijm, Menno
AU - Ackermann, Daniel
AU - Guessous, Idris
AU - Staessen, Jan A.
AU - Asayama, Kei
AU - Kutalik, Zoltan
AU - Vuistiner, Philippe
AU - Paccaud, Fred
AU - Pechere-Bertschi, Antoinette
AU - Mohaupt, Markus
AU - Vogt, Bruno
AU - Martin, Pierre-Yves
AU - Burnier, Michel
AU - Bochud, Murielle
PY - 2015/10
Y1 - 2015/10
N2 - Background:Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.Methods:The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.Results:The 518 women and 491 men included in this analysis had a mean (SD) age of 48.3 (+/- 17.4) and 47.3 (+/- 17.7) years, and a mean BMI of 23.8 (+/- 4.2) and 25.9 (+/- 4.1) kg/m(2), respectively. Narrow-sense heritability estimates (+/- standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 +/- 0.07, 0.26 +/- 0.07, and 0.29 +/- 0.07 for 24-h BP; 0.39 +/- 0.07, 0.28 +/- 0.07, and 0.27 +/- 0.07 for day BP; and 0.25 +/- 0.07, 0.20 +/- 0.07, and 0.30 +/- 0.07 for night BP, respectively (all P
AB - Background:Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are population-specific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample.Methods:The Swiss Kidney Project on Genes in Hypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software.Results:The 518 women and 491 men included in this analysis had a mean (SD) age of 48.3 (+/- 17.4) and 47.3 (+/- 17.7) years, and a mean BMI of 23.8 (+/- 4.2) and 25.9 (+/- 4.1) kg/m(2), respectively. Narrow-sense heritability estimates (+/- standard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 +/- 0.07, 0.26 +/- 0.07, and 0.29 +/- 0.07 for 24-h BP; 0.39 +/- 0.07, 0.28 +/- 0.07, and 0.27 +/- 0.07 for day BP; and 0.25 +/- 0.07, 0.20 +/- 0.07, and 0.30 +/- 0.07 for night BP, respectively (all P
KW - ambulatory blood pressure
KW - cross-sectional
KW - heritability
KW - population
U2 - 10.1097/HJH.0000000000000681
DO - 10.1097/HJH.0000000000000681
M3 - Article
C2 - 26203966
SN - 0263-6352
VL - 33
SP - 2061
EP - 2067
JO - Journal of Hypertension
JF - Journal of Hypertension
IS - 10
ER -